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View Structure Prediction Details

Protein: FBpp0294063, Tfb...
Organism: Drosophila melanogaster
Length: 585 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0294063, Tfb....

Description E-value Query
Range
Subject
Range
gi|125807859, gi... - gi|54635709|gb|EAL25112.1| GA20852 [Drosophila pseudoobscura pseudoobscura], gi|125807859|ref|XP_001...
gi|54635709|gb|E... - GA20852-PA [Drosophila pseudoobscura], GA20852 [Drosophila pseudoobscura pseudoobscura]
gi|194109927, gi... - gi|195150275|ref|XP_002016080.1| GL10686 [Drosophila persimilis], gi|194109927|gb|EDW31970.1| GL1068...
716.0 [0..1] [585..1]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSSEDVLL QMGEVRYKKG DGTLYVMNER VAWMAEHRDT VTVSHRYADI KTQKISPEGK  60
   61 PKVQLQVVLH DGNTSTFHFV NRQGQAAMLA DRDKVKELLQ QLLPNFKRKV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 1pfjA
Description: Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.19860786133833 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.05456820914801 bayes_pls_golite062009
nucleic acid binding 1.85794418941003 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
transcription elongation regulator activity 1.38051627844132 bayes_pls_golite062009
enzyme binding 0.977337620102034 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.704949129344961 bayes_pls_golite062009
protein kinase activity 0.565124275151513 bayes_pls_golite062009
structure-specific DNA binding 0.361321073558889 bayes_pls_golite062009
hydrolase activity 0.354215977182915 bayes_pls_golite062009
cytoskeletal protein binding 0.268141992393579 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.242734483980252 bayes_pls_golite062009
protein domain specific binding 0.236765394237244 bayes_pls_golite062009
kinase activity 0.206532566781865 bayes_pls_golite062009
kinase binding 0.144753921529348 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0735802149531289 bayes_pls_golite062009
actin binding 0.0485598963526399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLEDKNRIL VENPNLLQLY KDLVITKVLT SDEFWATHAK DHALKKMGRS QEIGVSGAFL  60
   61 ADIKPQTDGC NGLKYNLTSD VIHCIFKTYP AVKRKHFENV PAKMSEAEFW TKFFQS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.68
Match: 1x3aA
Description: Solution structure of the BSD domain of human Synapse associated protein 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [228-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYFHRDRLTA GTKDIFTECG KIDDQALKAA VQQGAGDPLL DLKKFEDVPL EEGFGSVAGD  60
   61 RNVVNSGNIV HQNMIKRFNQ HSIMVLKTCA NVTSAPSTMT NGT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [331-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNANGPVSQS AYTNGMNGKG QATATATKSS SDQVDKDEPQ SKKQRLMEKI HYVDLGDPIL  60
   61 EGDDSANGEK AKSKHFELSK VERYLNGPVQ NSMYDNHNDP MSLEEVQYKL VRNSESWLNR 120
  121 NVQRTFICSK AAVNALGELS PGGSMMRGFQ EQSAGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [487-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVPNDFQREL RHLYLSLSEL LKHFWSCFPP TSEELETKLQ RMHETLQRFK MAKLVPFENR  60
   61 AMHELSPLRS SLTQHLNQLL RTANSKFATW KERKLRNTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle