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View Structure Prediction Details

Protein: FBpp0294063, Tfb...
Organism: Drosophila melanogaster
Length: 585 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0294063, Tfb....

Description E-value Query
Range
Subject
Range
gi|125807859, gi... - gi|54635709|gb|EAL25112.1| GA20852 [Drosophila pseudoobscura pseudoobscura], gi|125807859|ref|XP_001...
gi|54635709|gb|E... - GA20852-PA [Drosophila pseudoobscura], GA20852 [Drosophila pseudoobscura pseudoobscura]
gi|194109927, gi... - gi|195150275|ref|XP_002016080.1| GL10686 [Drosophila persimilis], gi|194109927|gb|EDW31970.1| GL1068...
716.0 [0..1] [585..1]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSSEDVLL QMGEVRYKKG DGTLYVMNER VAWMAEHRDT VTVSHRYADI KTQKISPEGK  60
   61 PKVQLQVVLH DGNTSTFHFV NRQGQAAMLA DRDKVKELLQ QLLPNFKRKV D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 37.30103
Match: 1pfjA
Description: Solution structure of the N-terminal PH/PTB domain of the TFIIH P62 subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.19860786133833 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
transcription regulator activity 2.10584700564436 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.05456820914801 bayes_pls_golite062009
nucleic acid binding 1.85794418941003 bayes_pls_golite062009
DNA binding 1.77960272183811 bayes_pls_golite062009
transcription elongation regulator activity 1.38051627844132 bayes_pls_golite062009
enzyme binding 0.977337620102034 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.704949129344961 bayes_pls_golite062009
protein kinase activity 0.565124275151513 bayes_pls_golite062009
structure-specific DNA binding 0.361321073558889 bayes_pls_golite062009
hydrolase activity 0.354215977182915 bayes_pls_golite062009
cytoskeletal protein binding 0.268141992393579 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.242734483980252 bayes_pls_golite062009
protein domain specific binding 0.236765394237244 bayes_pls_golite062009
kinase activity 0.206532566781865 bayes_pls_golite062009
kinase binding 0.144753921529348 bayes_pls_golite062009
protein serine/threonine kinase activity 0.0735802149531289 bayes_pls_golite062009
actin binding 0.0485598963526399 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDLEDKNRIL VENPNLLQLY KDLVITKVLT SDEFWATHAK DHALKKMGRS QEIGVSGAFL  60
   61 ADIKPQTDGC NGLKYNLTSD VIHCIFKTYP AVKRKHFENV PAKMSEAEFW TKFFQS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.68
Match: 1x3aA
Description: Solution structure of the BSD domain of human Synapse associated protein 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [228-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYFHRDRLTA GTKDIFTECG KIDDQALKAA VQQGAGDPLL DLKKFEDVPL EEGFGSVAGD  60
   61 RNVVNSGNIV HQNMIKRFNQ HSIMVLKTCA NVTSAPSTMT NGT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [331-486]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNANGPVSQS AYTNGMNGKG QATATATKSS SDQVDKDEPQ SKKQRLMEKI HYVDLGDPIL  60
   61 EGDDSANGEK AKSKHFELSK VERYLNGPVQ NSMYDNHNDP MSLEEVQYKL VRNSESWLNR 120
  121 NVQRTFICSK AAVNALGELS PGGSMMRGFQ EQSAGQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [487-585]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVPNDFQREL RHLYLSLSEL LKHFWSCFPP TSEELETKLQ RMHETLQRFK MAKLVPFENR  60
   61 AMHELSPLRS SLTQHLNQLL RTANSKFATW KERKLRNTR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle