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Protein Overview: opa1-like-PB

General Information:
Name(s) found: opa1-like-PB / FBpp0086699 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene optic atrophy 1-like is referred to in FlyBase by the symbol Dmel\opa1-like (CG8479, FBgn0261276). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10118125..10122953. It has the cytological map location 50E4-50E5. Based on sequence similarity, it is predicted to have molecular function</span>: GTP binding. There is experimental evidence that it is involved in the biological process</span>: mitochondrial fusion; pupariation. 7 alleles are reported. The phenotype of these alleles is annotated with: mitochondrion. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 933 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: pupariation [IMP]
    mitochondrial fusion [IMP]
    Molecular Function: GTP binding [ISS]
    GTPase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRIYQNTYR RTARKAVVYS TKVACCNHST LCGITSHPRR AQDSGSSSSN GRHRGHEEFL  60
   61 LAGNPARGWQ MPPPSRGYGM LVVRILRGAL KLRYIVLGGA IGGGVSLSKK YEEWKDGLPN 120
  121 FKWLEDAMPQ GERWSQFSRN LIEVGSLVKN AIEVAKDDLK AKTTVAALGI TSDESRKKYE 180
  181 KLQSQVETLQ TEIMNVQIKY QKELEKMEKE NRELRQQYLI LKTNKKTTAK KIKKSLIDMY 240
  241 SEVLDELSGY DTGYTMADHL PRVVVVGDQS SGKTSVLESI AKARIFPRGS GEMMTRAPVK 300
  301 VTLAEGPYHV AQFRDSDREY DLTKESDLQD LRRDVEFRMK ASVRGGKTVS NEVIAMTVKG 360
  361 PGLQRMVLVD LPGIISTMTV DMASDTKDSI HQMTKHYMSN PNAIILCIQD GSVDAERSNV 420
  421 TDLVMQCDPL GRRTIFVLTK VDLAEELADP DRIRKILSGK LFPMKALGYY AVVTGRGRKD 480
  481 DSIDAIRQYE EDFFKNSKLF HRRGVIMPHQ VTSRNLSLAV SDRFWKMVRE TIEQQADAFK 540
  541 ATRFNLETEW KNNFPRLRES GRDELFDKAK GEILDEVVTL SQISAKKWDD ALSTKLWEKL 600
  601 SNYVFESIYL PAAQSGSQNS FNTMVDIKLR QWAEQALPAK SVEAGWEALQ QEFISLMERS 660
  661 KKAQDHDGIF DQLKSAVVDE AIRRHSWEDK AIDMLRVIQL NTLEDRFVHD KQEWDSAVKF 720
  721 LESSVNAKLV QTEETLAQMF GPGQMRRITH WQYLTQDQQK RRSVKNELDK ILKNDTKHLP 780
  781 TLTHDELTTV RKNLQRDNVD VDTDYIRQTW FPVYRKHFLQ QALQRAKDCR KAYYLYTQQG 840
  841 AECEISCSDV VLFWRIQQVI KITGNALRQQ VINREARRLD KEIKAVLDEF SDDEEKKGYL 900
  901 LTGKRVLLAE ELIKVRQIQE KLEEFINSLN QEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..98] deduced N/A No confident structure predictions are available.
    2 View Details [99..223] PSI-BLAST 30.522879 Structure of the GTP-binding protein TrmE from Thermotoga maritima
    3 View Details [224..602] PSI-BLAST 64.0 Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus
    4 View Details [603..662] deduced N/A No confident structure predictions are available.
    5 View Details [663..855] deduced N/A No confident structure predictions are available.
    6 View Details [856..933] MSA 2.32799 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • microtubule motor activity
    		•  3.64858540496165 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.89122312915795 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.81593838944939 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.79724985811732 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.79347973548337 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity
    		•  2.44176688200537 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.38215814751368 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • motor activity
    		•  2.1532118704195 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • hydrolase activity
    		•  1.40217504818333 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.990320704369021 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • protein transporter activity
    		•  0.712797684532763 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • tubulin binding
    		•  0.326239364039846 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.28297830193871 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.226790072388501 bayes_pls_golite062009
  • microtubule binding
    		•  0.225323885896927 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.194779852865789 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle