Protein Overview: cg-PB

General Information:
Name(s) found:	cg-PB / FBpp0086656 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene combgap is referred to in FlyBase by the symbol Dmel\cg (CG8367, FBgn0000289). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10061175..10070345. It has the cytological map location 50E1. It is reported to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis. 30 alleles are reported. The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; nervous system; peripheral nervous system; mushroom body; antennal segment; larval thorax; metatarsus. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	772 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS]
Biological Process:	imaginal disc-derived wing morphogenesis [IMP]
Molecular Function:	nucleic acid binding [IEA] transcription factor activity [NAS] zinc ion binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAAQNPPPF GYTWGFADNG NRAAESVLEI SPNINYTVSG ESMPYLLSTD GSLAVQKDVK  60
   61 GLTAGGKNNV VRRMFVVNDP SFPPGTQRVI TAGGASTVVK KQDNNQQVLS LDKNYLLVDP 120
  121 ATAAAAAAAA GGDSGLAHHH TLTNGSIVDA KTGQTVLTAG SAAAKSHFSS IGALHLTQEE 180
  181 CNEILIKRAI AAGHHQTHTI TAADGSHHHA SGGTPSDILP GISVQVQKVI QGLEDNEDSQ 240
  241 GEAPNLKLEP GTLELSPKTE LQESMHFSET DATIKKERPY SCDECGKSFL LKHHLTTHAR 300
  301 VHTGERPHIC THCGKSFAHK HCLNTHLLLH STERPYQCQE CKKSFTLKHH LLTHSRVHSR 360
  361 ERPFVCQECG RAFPLKRHLV THSKFHAGER PYVCEECGES FAQENHLIMH SRFHGSLNPF 420
  421 VCAECGASFP RKFQLVNHGR IHGKIPHSCT VCGKEFLQKR TLVSHMRRVH TGEQAHPCVS 480
  481 CGEGFLTKAE LHQHVRTAHN GVNPNTSSAT IIANQQLQQA HHHQAGQQTH PQTITVVSNP 540
  541 GNSTLLTVST TDANGVARPQ FVCRECGSAF NSREALALHL RLHTGDKSLM TDLCALTAAL 600
  601 PGHFLSTASL NPGTVVTANP NLVGQSPVPV QIISSTGQVM SQTTLVQAAN STHPQAVVTA 660
  661 VPTMPVHGQQ QHLQHVAQQQ QQQQQQQQQQ QQHVVSVAPA NKPKSHFCAS CGKGFAAKHG 720
  721 LMQHNRRHPN GGCTVRTHVC ECGKAFFQKN HLMLHQRQHL ETKPAISQQQ VC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..203]	MSA	1.379958	View MSA. No confident structure predictions are available.
2	View Details	[204..445]	PSI-BLAST	62.0	No description for 2i13A was found.
3	View Details	[446..618]	PSI-BLAST	18.69897	Five-finger GLI1
4	View Details	[619..701]	MSA	1.295996	View MSA. No confident structure predictions are available.
5	View Details	[702..772]	PSI-BLAST	8.221849	Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

No functions predicted.

3

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
structure-specific DNA binding	1.48624530884061	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
double-stranded DNA binding	1.18599503594288	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

4

No functions predicted.

5

Term	Confidence	Notes
transcription regulator activity	4.70988788192472	bayes_pls_golite062009
nucleic acid binding	4.58713908116892	bayes_pls_golite062009
DNA binding	4.56219307357342	bayes_pls_golite062009
transcription factor activity	3.50954949535763	bayes_pls_golite062009
transcription repressor activity	3.27542149084008	bayes_pls_golite062009
RNA polymerase II transcription factor activity	3.22082323675675	bayes_pls_golite062009
binding	3.10743787485868	bayes_pls_golite062009
transcription activator activity	2.19952417915035	bayes_pls_golite062009
chromatin binding	2.18464662431232	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	1.63161912031789	bayes_pls_golite062009
structure-specific DNA binding	1.48624530884061	bayes_pls_golite062009
sequence-specific DNA binding	1.42975942698743	bayes_pls_golite062009
transcription factor binding	1.39608963544799	bayes_pls_golite062009
transcription corepressor activity	1.34049786451995	bayes_pls_golite062009
double-stranded DNA binding	1.18599503594288	bayes_pls_golite062009
protein binding	1.00484935878505	bayes_pls_golite062009
transcription cofactor activity	0.77874411480713	bayes_pls_golite062009
catalytic activity	0.245893663605433	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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