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Protein Overview: Cp1-PC

General Information:
Name(s) found: Cp1-PC / FBpp0086719 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Cysteine proteinase-1 is referred to in FlyBase by the symbol Dmel\Cp1 (CG6692, FBgn0013770). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9848164..9855496. It has the cytological map location 50C18-50C20. Based on sequence similarity, it is predicted to have molecular function</span>: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: autophagic cell death; salivary gland cell autophagic cell death. 32 alleles are reported. The phenotypes of these alleles are annotated with: egg; adult abdominal segment 3; adult abdominal segment 1; adult abdominal segment 5; wing; adult abdominal segment 2; adult abdominal segment 4. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 371 amino acids

    Gene Ontology:
    Cellular Component: lysosome [NAS]
    Biological Process: protein catabolic process [NAS]
    autophagic cell death [IEP]
    proteolysis [IEA]
    salivary gland cell autophagic cell death [IEP]
    Molecular Function: cysteine-type endopeptidase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNHLGVFETR FRPRTRHKSQ RAQLIPEQIT MRTAVLLPLL ALLAVAQAVS FADVVMEEWH  60
   61 TFKLEHRKNY QDETEERFRL KIFNENKHKI AKHNQRFAEG KVSFKLAVNK YADLLHHEFR 120
  121 QLMNGFNYTL HKQLRAADES FKGVTFISPA HVTLPKSVDW RTKGAVTAVK DQGHCGSCWA 180
  181 FSSTGALEGQ HFRKSGVLVS LSEQNLVDCS TKYGNNGCNG GLMDNAFRYI KDNGGIDTEK 240
  241 SYPYEAIDDS CHFNKGTVGA TDRGFTDIPQ GDEKKMAEAV ATVGPVSVAI DASHESFQFY 300
  301 SEGVYNEPQC DAQNLDHGVL VVGFGTDESG EDYWLVKNSW GTTWGDKGFI KMLRNKENQC 360
  361 GIASASSYPL V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..371] PSI-BLAST 89.30103 (Pro)cathepsin L

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  4.90619850296986 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.64381885397949 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.75054525912786 bayes_pls_golite062009
  • hydrolase activity
    		•  3.74079711298952 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.71117522993364 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.95802900199539 bayes_pls_golite062009
  • binding
    		•  1.29265216891074 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.12653729823589 bayes_pls_golite062009
  • catalytic activity
    		•  1.05972260874031 bayes_pls_golite062009
  • protein binding
    		•  0.774177093888744 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  0.649171767629235 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.59115205419466 bayes_pls_golite062009
  • kininogen binding
    		•  0.41283715939055 bayes_pls_golite062009
  • signal transducer activity
    		•  0.12644030784065 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.12644030784065 bayes_pls_golite062009
  • structural molecule activity
    		•  0.102555314244558 bayes_pls_golite062009
  • tubulin binding
    		•  0.0482209771629902 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  0.0101379718864654 bayes_pls_golite062009
  • microtubule binding
    		•  0.00635493133568055 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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