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Protein Overview: stj-PB

General Information:
Name(s) found: stj-PB / FBpp0086757 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene straightjacket is referred to in FlyBase by the symbol Dmel\stj (CG12295, FBgn0261041). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9692979..9707080. It has the cytological map location 50C5-50C6. Based on sequence similarity, it is predicted to have molecular function</span>: voltage-gated calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of synaptic growth at neuromuscular junction; neuromuscular synaptic transmission; synaptic vesicle fusion to presynaptic membrane. 25 alleles are reported. The phenotypes of these alleles are annotated with: larval neuromuscular junction; embryonic/larval somatic muscle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1218 amino acids

    Gene Ontology:
    Cellular Component: voltage-gated calcium channel complex [ISS]
    synapse [IDA]
    Biological Process: neuromuscular synaptic transmission [IMP]
    synaptic vesicle fusion to presynaptic membrane [IMP]
    negative regulation of synaptic growth at neuromuscular junction [IMP]
    Molecular Function: voltage-gated calcium channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAWSRLLAWW RLCLGLLSVL VCLAPCVNLQ PAENINYNLV HSWADKLGME LFHLGDFITR  60
   61 RKEVQESFKD AKVVSRNGAS IVDSMAKEIE MMMDLKVSAV RRIMDTAENT ALSHQNDMAD 120
  121 KMFSYYSAKE MLEPGDPVPP IPTPAPDMDK DIGEPLIYVQ PKVVVLEPRP EFHNTPVNFS 180
  181 VSSVHVPVNV FDRAPDVIKA IQWSENLDQI FRDNYKNDPT LSWQFFGSST GFMRQFPASK 240
  241 WRKDVPVDLY DCRLRSWYME AATSPKDIVI LMDGSGSMLG QRLDIAKHVV NTILDTLGTN 300
  301 DFVNIFTFDK EVSPVVPCFE DTLIQANLGN IRELKEGIEL FRPKSIANYT AALTKAFELL 360
  361 EETKLSSRGA QCNQAIMIIG DGAPENNREV FELHNWRDPP YKPVRVFTYL IGKEVANWDD 420
  421 IRWMACENQG YYVHLSDTAE VREMVLNYIP VMARPLVLGR HDHPVIWSQV YADIEDTKLS 480
  481 DYLWDINQCE YQKADVLEYW QVHDRMLEPS EMHRRKYRRM KETWNQPVDS NVYQFMTTVS 540
  541 MPIYDRRENA TRIANILGVA GTDVPINEIK KLLSPFTLGV NGYAFIVTNN GYVLFHPDFR 600
  601 PIFQGYILKP AYNSVDMIEV ELLDDDRPAR DFNPVLMTIR DSIINQSTGS KWMLVKNHFD 660
  661 EMKRVARVKR QYYWTAIKKT PFTLVISYPE QYGVSHMDIR ADQEIHRISI KGTNLRSVFS 720
  721 GKRWKIHPDW LFCKHSNRTF KTPEIELLYF LERMSEPGWR WPGSRSAMPP EHAAAMFCDR 780
  781 QLMQALVFDA RVTGWFSNNT SFNSKDDKGN EFKQRFGVTV AFLATHSGLT RWHEFHSNAA 840
  841 EESGVGETFS QNNTRAIDEI WYKRAVDQHF VREESFVYSV PFDAGESNSE ILVTASHAVF 900
  901 HNEGGKTAPA AVVGFQFQHS ALYKLFHNIT GNACAVDDKD CYILDNNGYV IISTRVHETG 960
  961 RFFGEVNGAI MKRLLEENVY RQVTVYDYQA VCFESKNDNN ASSMLLSPLF HLLRVGKWLL1020
 1021 HTALWYIVQL LQWAPGVSSH YADMYGDSND TEPPPPEPHP DHHARNGNGH GKKDDDHWLR1080
 1081 YLTLHRTRLK PCDMKRDLYT LFNEKDNVVY NMTAHACERP FVVLPIPFSN LILLVIDQLC1140
 1141 PRDGSVVLTV NPQPIDYHLS VNDSLACYKQ AREFNRMRPH SCISRHANES GIKLCGKACS1200
 1201 VYANLGLLLL CHILSRWL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 15.522879 The mouse von Willebrand Factor A1-botrocetin complex
    2 View Details [172..588] PSI-BLAST 24.69897 No description for 2ok5A was found.
    3 View Details [589..736] FFAS03 1.24 No description for 2qhkA was found.
    4 View Details [737..964] FFAS03 1.62 No description for 2p7jA was found.
    5 View Details [965..1218] MSA 1.062953 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transmembrane receptor activity
    		•  3.33848773229348 bayes_pls_golite062009
  • receptor activity
    		•  3.28133222509881 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.08213334732736 bayes_pls_golite062009
  • signal transducer activity
    		•  3.08213334732736 bayes_pls_golite062009
  • integrin binding
    		•  2.40435388753557 bayes_pls_golite062009
  • binding
    		•  2.35148208532935 bayes_pls_golite062009
  • protein complex binding
    		•  2.17431257567104 bayes_pls_golite062009
  • glutamate receptor activity
    		•  2.15452584224197 bayes_pls_golite062009
  • protein binding
    		•  1.87564165872234 bayes_pls_golite062009
  • olfactory receptor activity
    		•  1.66481660196007 bayes_pls_golite062009
  • cell surface binding
    		•  1.51066809142894 bayes_pls_golite062009
  • transporter activity
    		•  1.30184925420876 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  0.89254588900557 bayes_pls_golite062009
  • receptor binding
    		•  0.79473181810599 bayes_pls_golite062009
  • pattern binding
    		•  0.619246923808839 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.536585839391392 bayes_pls_golite062009
  • phospholipid binding
    		•  0.36876716174996 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.36562246631989 bayes_pls_golite062009
  • complement binding
    		•  0.32786837080852 bayes_pls_golite062009
  • cytokine binding
    		•  0.22632966660558 bayes_pls_golite062009
  • immunoglobulin binding
    		•  0.210450684404 bayes_pls_golite062009
  • heparin binding
    		•  0.190564147009143 bayes_pls_golite062009
  • collagen binding
    		•  0.161881783569751 bayes_pls_golite062009
  • glycoprotein binding
    		•  0.0903628367778293 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0661625326929309 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.027305897174472 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0179622467180781 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0153681945260867 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • signal transducer activity
    		•  3.13256594661032 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13256594661032 bayes_pls_golite062009
  • binding
    		•  1.41605711466109 bayes_pls_golite062009
  • protein kinase activity
    		•  1.20041834925823 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.683556549389236 bayes_pls_golite062009
  • protein binding
    		•  0.582195331775352 bayes_pls_golite062009
  • kinase activity
    		•  0.46187777247322 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.223262726188973 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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