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Protein Overview: Dp-PB

General Information:
Name(s) found: Dp-PB / FBpp0086854 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene DP transcription factor is referred to in FlyBase by the symbol Dmel\Dp (CG4654, FBgn0011763). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9109902..9115714. It has the cytological map location 49F10-49F11. There is experimental evidence that it has the molecular function</span>: protein binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene expression; positive regulation of nurse cell apoptosis; oogenesis; dorsal/ventral axis specification, ovarian follicular epithelium; regulation of cell cycle; cell cycle. 31 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; peripheral nervous system; external compound sense organ; nervous system; female germline cyst; adult segment; compound cell cluster organ; cell part; nucleus; egg; cell cycle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 441 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCISETKEPP HLPISNSAGQ ISKMLKPAQN KSEMEGGKPV AVVYATGSSA RNSGSASGIG  60
   61 NVGRMGAFSQ MGSQGQFIRL QDNGLSIPKT EAGTTYTTVS AQKTSGAGSG HYDLPLKGDR 120
  121 YVKFTPNPIK MKSKLHAIQS NSLHSMSASS SSVQRKRKPD KAGKGLRHFS MKVCEKVEEK 180
  181 GKTTYNEVAD DLVSEEMKNN AYDNNCDQKN IRRRVYDALN VLMAINVISK DKKEIRWIGL 240
  241 PANSTETFLA LEEENCQRRE RIKQKNEMLR EMIMQHVAFK GLVERNKRNE SQGVVPSPNA 300
  301 SIQLPFIIVN THKSTKINCS VTNDKSEYIF KFDKTFEMHD DIEVLKRMGF LLGLDKGECT 360
  361 PENIERVKSW VPPNLAKYVE AYGTGKTGEN MYESDDEDNE FNGYLESANE SQGFAQHSAQ 420
  421 HTTDGEFKLE MDDDELDDDI D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] MSA 3.112991 View MSA. No confident structure predictions are available.
    2 View Details [146..241] PSI-BLAST 32.0 Cell cycle transcription factor DP-2
    3 View Details [242..441] PSI-BLAST 54.0 Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • DNA binding
    		•  5.08959163553491 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.99681957904233 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription activator activity
    		•  3.66421521631643 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.54603684370312 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.60738445921725 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.22485867684613 bayes_pls_golite062009
  • protein binding
    		•  1.80415286835431 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.2723726467408 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.913018999939773 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.697234220778482 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.66743181561551 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.300899564141452 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.23177057841536 bayes_pls_golite062009
  • structural molecule activity
    		•  0.111941063082739 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle