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Protein Overview: FBpp0086882, lat-PA

General Information:
Name(s) found: FBpp0086882 [FlyBase]
lat-PA / FBpp0086881 [FlyBase]
Description(s) found:
Found 34 descriptions.
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  • type=protein; loc=2R:complement(9090361..9090457,9090523..9091760,9091820..9092623,9092687..9092713); ID=FBpp0086882; name=lat-PB; parent=FBgn0005654,FBtr0087769; dbxref=GB_protein:AAM68599.1,FlyBase:FBpp0086882,FlyBase_Annotation_IDs:CG4088-PB,GB_protein:AAM68599,REFSEQ:NP_725260; MD5=93b15682f79f020c5f9c95d00cf4a724; length=721; release=r5.56; species=Dmel; [FlyBase]
  • The gene latheo is referred to in FlyBase by the symbol Dmel\lat (CG4088, FBgn0005654). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9090248..9094027. It has the cytological map location 49F7-49F8. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: DNA replication initiation. 38 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; bouton; nerve terminal; imaginal disc; larval central nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 721 amino acids

    Gene Ontology:
    Cellular Component: nuclear origin of replication recognition complex [IDA][ISS]
    Biological Process: larval feeding behavior [NAS]
    DNA replication initiation [IDA]
    DNA replication [IEA][NAS]
    olfactory learning [TAS]
    learning [NAS]
    learning or memory [NAS]
    Molecular Function: DNA binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPTISVSKG CFVYKNGATR AGKKAASKRK RPAAESSSLL GKEVVQQPFY EEYRKAWNQI  60
   61 NDHIADLQHR SYARTLEQLV DFVVGQAERD TPDEVLPTAA LLTGINQPDH LSQFTALTQR 120
  121 LHAQRAAMVC VLQSRDCATL KAAVETLVFG LVEDNAEVEQ MEDEDEDEDG AERDRKRLRR 180
  181 SQCTMKQLKS WYTNNFDSEQ KRRQLVVILP DFECFNASVL QDLILILSAH CGSLPFVLVL 240
  241 GVATAMTAVH GTLPYHVSSK IRLRVFQTQA APTGLNEVLD KVLLSPKYAF HLSGKTFKFL 300
  301 THIFLYYDFS IHGFIQGFKY CLMEHFFGGN AFALCTDYSK ALGRIKQLTH EDMETIRRLP 360
  361 SFRPYVEQIN DCKRIIAVLT DDDYLKKKLP QLLRDCLLHF LLFRCSLEFL TELVGDLPRC 420
  421 PLGKLRRELY VNCLNRAIIS TPEYKECLQM LSFLSKDEFV AKVNRALERT EQFLVEEIAP 480
  481 LELGEACTAV LRPKLEAIRL AVDEVVKATM ATITTTSPNE TRQATDHLTP VASRQELKDQ 540
  541 LLQRSKEDKM RHQLNTPTTQ FGRALQKTLQ LIETQIVQDH LRALQDAPPI HELFVFSDIA 600
  601 TVRRNIIGAP RAALHTALNN PHFYMQCKCC ELQDQSLLVG TLPDLSVVYK LHLECGRMIN 660
  661 LFDWLQAFRS VVSDSDHEEV AQEQIDPQIQ ARFTRAVAEL QFLGYIKMSK RKTDHATRLT 720
  721 W

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..515] FFAS03 1.02 CDC6, C-terminal domain; CDC6, N-domain
    2 View Details [516..721] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.02220304275406 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  2.98512761739082 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.51056345830226 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.07805757910215 bayes_pls_golite062009
  • binding
    		•  1.98872728862535 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.86107760494079 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.67733655597151 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.51095871692451 bayes_pls_golite062009
  • helicase activity
    		•  1.47239452959713 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46809935501802 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.962068859908115 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.962068859908115 bayes_pls_golite062009
  • DNA binding
    		•  0.959585045949425 bayes_pls_golite062009
  • catalytic activity
    		•  0.942640875796745 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.902971700296229 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.863214173324181 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.779711797772654 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.697536582328083 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.481409758059649 bayes_pls_golite062009
  • motor activity
    		•  0.412856426548665 bayes_pls_golite062009
  • protein binding
    		•  0.182543549489122 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0988428757344488 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle