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View Structure Prediction Details

Protein: FBpp0086882, lat-PA
Organism: Drosophila melanogaster
Length: 721 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0086882, lat-PA.

Description E-value Query
Range
Subject
Range
gi|5081626 - gi|5081626|gb|AAD39472.1|AF139062_1 origin recognition complex subunit 3 [Drosophila melanogaster]
854.0 [0..1] [721..1]

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Predicted Domain #1
Region A:
Residues: [1-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPTISVSKG CFVYKNGATR AGKKAASKRK RPAAESSSLL GKEVVQQPFY EEYRKAWNQI  60
   61 NDHIADLQHR SYARTLEQLV DFVVGQAERD TPDEVLPTAA LLTGINQPDH LSQFTALTQR 120
  121 LHAQRAAMVC VLQSRDCATL KAAVETLVFG LVEDNAEVEQ MEDEDEDEDG AERDRKRLRR 180
  181 SQCTMKQLKS WYTNNFDSEQ KRRQLVVILP DFECFNASVL QDLILILSAH CGSLPFVLVL 240
  241 GVATAMTAVH GTLPYHVSSK IRLRVFQTQA APTGLNEVLD KVLLSPKYAF HLSGKTFKFL 300
  301 THIFLYYDFS IHGFIQGFKY CLMEHFFGGN AFALCTDYSK ALGRIKQLTH EDMETIRRLP 360
  361 SFRPYVEQIN DCKRIIAVLT DDDYLKKKLP QLLRDCLLHF LLFRCSLEFL TELVGDLPRC 420
  421 PLGKLRRELY VNCLNRAIIS TPEYKECLQM LSFLSKDEFV AKVNRALERT EQFLVEEIAP 480
  481 LELGEACTAV LRPKLEAIRL AVDEVVKATM ATITT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.02
Match: 1fnnA
Description: CDC6, C-terminal domain; CDC6, N-domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA clamp loader activity 3.02220304275406 bayes_pls_golite062009
protein-DNA loading ATPase activity 2.98512761739082 bayes_pls_golite062009
DNA-dependent ATPase activity 2.51056345830226 bayes_pls_golite062009
DNA helicase activity 2.07805757910215 bayes_pls_golite062009
binding 1.98872728862535 bayes_pls_golite062009
pyrophosphatase activity 1.86107760494079 bayes_pls_golite062009
ATP-dependent DNA helicase activity 1.67733655597151 bayes_pls_golite062009
DNA replication origin binding 1.51095871692451 bayes_pls_golite062009
helicase activity 1.47239452959713 bayes_pls_golite062009
nucleic acid binding 1.46809935501802 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.962068859908115 bayes_pls_golite062009
ATP-dependent helicase activity 0.962068859908115 bayes_pls_golite062009
DNA binding 0.959585045949425 bayes_pls_golite062009
catalytic activity 0.942640875796745 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.902971700296229 bayes_pls_golite062009
DNA polymerase activity 0.863214173324181 bayes_pls_golite062009
transcription regulator activity 0.779711797772654 bayes_pls_golite062009
structure-specific DNA binding 0.697536582328083 bayes_pls_golite062009
double-stranded DNA binding 0.481409758059649 bayes_pls_golite062009
motor activity 0.412856426548665 bayes_pls_golite062009
protein binding 0.182543549489122 bayes_pls_golite062009
structural constituent of ribosome 0.0988428757344488 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [516-721]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSPNETRQAT DHLTPVASRQ ELKDQLLQRS KEDKMRHQLN TPTTQFGRAL QKTLQLIETQ  60
   61 IVQDHLRALQ DAPPIHELFV FSDIATVRRN IIGAPRAALH TALNNPHFYM QCKCCELQDQ 120
  121 SLLVGTLPDL SVVYKLHLEC GRMINLFDWL QAFRSVVSDS DHEEVAQEQI DPQIQARFTR 180
  181 AVAELQFLGY IKMSKRKTDH ATRLTW

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle