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Protein Overview: TppII-PD

General Information:
Name(s) found: TppII-PD / FBpp0086887 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene tripeptidyl-peptidase II is referred to in FlyBase by the symbol Dmel\TppII (CG3991, FBgn0020370). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:9040393..9046595. It has the cytological map location 49F4. There is experimental evidence that it has the molecular function</span>: tripeptidyl-peptidase activity; exopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: protein homooligomerization; proteolysis. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1441 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: proteolysis [IDA]
    protein homooligomerization [IDA]
    Molecular Function: tripeptidyl-peptidase activity [IDA][ISS]
    serine-type endopeptidase activity [IEA]
    exopeptidase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNRFRLVHK QLRLYKNFGL LGQKASVGLT LPIISLSRPY MAYMGTERSV VMITAPATKE  60
   61 FAESSERSNS SKKTTNKEQS DKSAESRMAT SGIVESFPTG ALVPKAETGV LNFLQKYPEY 120
  121 DGRDVTIAIF DSGVDPRATG LETLCDGKTV KVIERYDCSG CGDVDMKKKV TPDENGNIKG 180
  181 LSGNSLKLSP ELMALNTDPE KAVRVGLKSF SDLLPSKVRN NIVAQAKLKH WDKPHKTATA 240
  241 NASRKIVEFE SQNPGEASKL PWDKKILKEN LDFELEMLNS YEKVYGDIKT SYDCILFPTA 300
  301 DGWLTIVDTT EQGDLDQALR IGEYSRTHET RNVDDFLSIS VNVHDEGNVL EVVGMSSPHG 360
  361 THVSSIASGN HSSRDVDGVA PNAKIVSMTI GDGRLGSMET GTALVRAMTK VMELCRDGRR 420
  421 IDVINMSYGE HANWSNSGRI GELMNEVVNK YGVVWVASAG NHGPALCTVG TPPDISQPSL 480
  481 IGVGAYVSPQ MMEAEYAMRE KLPGNVYTWT SRDPCIDGGQ GVTVCAPGGA IASVPQFTMS 540
  541 KSQLMNGTSM AAPHVAGAVA LLISGLKQQN IEYSPYSIKR AISVTATKLG YVDPFAQGHG 600
  601 LLNVEKAFEH LTEHRQSKDN MLRFSVRVGN NADKGIHLRQ GVQRNSIDYN VYIEPIFYND 660
  661 KEADPKDKFN FNVRLNLIAS QPWVQCGAFL DLSYGTRSIA VRVDPTGLQP GVHSAVIRAY 720
  721 DTDCVQKGSL FEIPVTVVQP HVLESDQNTP VFEPASSKGD NSVEFQPNTI QRDFILVPER 780
  781 ATWAELRMRI TDPNRGEDIG KFFVHTNQLL PKQSCRKLET MKIVSVGSEN ESIMAFKVKS 840
  841 GRILELCIAK YWSNYGQSHL KYSLRFRGVE AHNPNAYVMH AGRGIHKLEI EALVAEDVQP 900
  901 QLQLKNAEVV LKPTEAKISP LSATRDVIPD GRQVYQNLLA FNLNVAKAAD VSIYAPIFND 960
  961 LLYEAEFESQ MWMLFDANKA LVATGDAHSH TSFTKLDKGE YTIRLQVRHE KRDLLEKISE1020
 1021 ANLVASFKLT SPLTLDFYEN YNQCIVGGRK YVSSPLRLST RVLYIAPITQ ERLTKANLPA1080
 1081 QCAWLSGNLV FPQDEVGRRV AQHPFTYILN PAEKKSHTNG SSNGSSAAGS TATAAAVTTA1140
 1141 NGAKPKAPAT PQAATSVTNP AAGDGISVQN DPPVDSSGSP ASPKKGKANA DDYAESFRDF1200
 1201 QCSQIVKCEL EMAEKIYNDV VAAHPKHLQA NLLLIQNIES NQLKSQLPLT FVNAQKTSPP1260
 1261 EAGESADKQK EDQKKVRSAL ERIVKLADKV IQETDSEALL SYYGLKNDTR ADAAKIKTNM1320
 1321 DKQKNTLIEA LSKKGIAVAK LAVLDDCIKD SLAEINELYT EIIKFVDAND SKAIQFALWH1380
 1381 AYAHGHYGRM YKYVVKLIEE KRTRDHFVEL AAINGALGHE HIRTVINRMM ITAFPSSFRL1440
 1441 F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..198] FFAS03 3.26 No description for 2e1pA was found.
    2 View Details [199..882] PSI-BLAST 48.39794 Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
    3 View Details [883..1111] deduced N/A No confident structure predictions are available.
    4 View Details [1112..1265] MSA 2.025974 View MSA. No confident structure predictions are available.
    5 View Details [1266..1441] MSA 1.020948 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.27205998189496 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.98068870917241 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.34981838083066 bayes_pls_golite062009
  • hydrolase activity
    		•  1.91868221854892 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.90036575189745 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.89198766955068 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  1.23150012549143 bayes_pls_golite062009
  • binding
    		•  0.929059396533194 bayes_pls_golite062009
  • protein binding
    		•  0.688150050556688 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle