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Protein Overview: Amph-PA

General Information:
Name(s) found: Amph-PA / FBpp0086941 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Amphiphysin is referred to in FlyBase by the symbol Dmel\Amph (CG8604, FBgn0027356). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8481088..8499578. It has the cytological map location 49B7-49B8. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: protein localization; regulation of muscle contraction; rhabdomere membrane biogenesis; rhabdomere development. 23 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; macrochaeta; motor neuron; indirect flight muscle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 602 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    synapse [IDA]
    plasma membrane [IDA]
    Biological Process: synaptic vesicle endocytosis [IEP][IMP][TAS]
    rhabdomere development [IMP]
    regulation of muscle contraction [IMP]
    protein localization [IMP]
    rhabdomere membrane biogenesis [IMP]
    endocytosis [NAS]
    exocytosis [TAS]
    neurotransmitter secretion [NAS]
    Molecular Function: protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTENKGIMLA KSVQKHAGRA KEKILQNLGK VDRTADEIFD DHLNNFNRQQ ASANRLQKEF  60
   61 NNYIRCVRAA QAASKTLMDS VCEIYEPQWS GYDALQAQTG ASESLWADFA HKLGDQVLIP 120
  121 LNTYTGQFPE MKKKVEKRNR KLIDYDGQRH SFQNLQANAN KRKDDVKLTK GREQLEEARR 180
  181 TYEILNTELH DELPALYDSR ILFLVTNLQT LFATEQVFHN ETAKIYSELE AIVDKLATES 240
  241 QRGSNTLRKQ TSNPIKTSSP VQSPVNKLNN ANINSNYQNQ ITTNGGSSLA NSPTSTSSSL 300
  301 QEPRFDSVSS TPEPRPESPA AALVSATPSS PVENGVTTKS LERPELSGLN ASAKATTTTQ 360
  361 TSPTEDKAVV SEAVKPSETE GAAVAASVTP APPATPAQIN GNNNEPSIVK EGGKQPKELP 420
  421 STTSNAEAAA EAAANNGNSI EEHKQKKLGN DTTVTATETV TVTQHSVTST DTDNIVTISD 480
  481 TNTDTDTKTS TGTSQKGRPV PVVNRHSVNN LNKNPFEDDD ERIYEVPADA NTADLPPGVL 540
  541 YRVKATYGYA KEDVDELSFE IGDLIRVIEY DDPEDQEEGW LMGQKEGTNE KGLFPANFTR 600
  601 PI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] PSI-BLAST 54.522879 Amphiphysin BAR domain from Drosophila
    2 View Details [244..330] deduced N/A No confident structure predictions are available.
    3 View Details [331..602] PSI-BLAST 15.30103 NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  2.86582611923959 bayes_pls_golite062009
  • binding
    		•  2.43584893484993 bayes_pls_golite062009
  • protein binding
    		•  1.87308005875135 bayes_pls_golite062009
  • signal transducer activity
    		•  1.15315260510573 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.15315260510573 bayes_pls_golite062009
  • GTPase binding
    		•  0.50066793947946 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.459881864914566 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.456472132383968 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.180886944097381 bayes_pls_golite062009
  • small GTPase binding
    		•  0.0531578648468707 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle