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Protein Overview: Buffy-PA

General Information:
Name(s) found: Buffy-PA / FBpp0087182 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Buffy is referred to in FlyBase by the symbol Dmel\Buffy (CG8238, FBgn0040491). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7566978..7576264. It has the cytological map location 48C1. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: anti-apoptosis. 8 alleles are reported. The phenotype of these alleles is annotated with: embryonic nervous system. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 299 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: anti-apoptosis [IGI][IMP]
    induction of apoptosis [ISS]
    apoptosis [ISS][NAS]
    regulation of apoptosis [TAS]
    programmed cell death [TAS]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGTSYPTNN DNFSNGFPMA TTQSERLLQA QNRRKFSFPA TLHSASLLEV GGGPKETTRR  60
   61 RLSNVSDAVT RKLSYTIGWK AAQIPAQDII SQGRCLCGHY IKRRLRRSGL FNKKLGLQRI 120
  121 RSILGSTSMG IVRDVFPAVQ VLGDELERMH PRIYNGVARQ ICRNPGGEFH TPDAVSLLLG 180
  181 AVGRELFRVE ITWSKVISLF AIAGGLSVDC VRQGHPEYLP KLMESVSEVI EDELVPWINE 240
  241 NGGWSGINTH VLPTTNSLNP LEWTTLVIGV VFGLILVFMI LRFIFNLIVP KIYQRFTNS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..299] PSI-BLAST 46.0 Proapoptotic molecule Bax

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  2.32513226847241 bayes_pls_golite062009
  • binding
    		•  1.68532136060219 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.00006462805615 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.88825596389518 bayes_pls_golite062009
  • BH3 domain binding
    		•  0.73278409982916 bayes_pls_golite062009
  • death domain binding
    		•  0.583637336305401 bayes_pls_golite062009
  • BH domain binding
    		•  0.513227895728431 bayes_pls_golite062009
  • caspase inhibitor activity
    		•  0.0810673056766702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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