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Protein Overview: Taf5-PA

General Information:
Name(s) found: Taf5-PA / FBpp0087335 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene TBP-associated factor 5 is referred to in FlyBase by the symbol Dmel\Taf5 (CG7704, FBgn0010356). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6764808..6767175. It has the cytological map location 47C5. Based on sequence similarity, it is predicted to have molecular function</span>: general RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of transcription from RNA polymerase II promoter. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    transcription factor TFIID complex [IPI][ISS]
    SAGA complex [IPI]
    Biological Process: regulation of transcription, DNA-dependent [NAS]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: general RNA polymerase II transcription factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEVSNING GNGTQLSHDK RELLCLLKLI KKYQLKSTEE LLCQEANVSS VELSEISESD  60
   61 VQQVLGAVLG AGDANRERKH VQSPAQGHKQ SAVTEANAAE ELAKFIDDDS FDAQHYEQAY 120
  121 KELRTFVEDS LDIYKHELSM VLYPILVQIY FKILASGLRE KAKEFIEKYK CDLDGYYIEG 180
  181 LFNLLLLSKP EELLENDLVV AMEQDKFVIR MSRDSHSLFK RHIQDRRQEV VADIVSKYLH 240
  241 FDTYEGMARN KLQCVATAGS HLGEAKRQDN KMRVYYGLLK EVDFQTLTTP APAPEEEDDD 300
  301 PDAPDRPKKK KPKKDPLLSK KSKSDPNAPS IDRIPLPELK DSDKLLKLKA LREASKRLAL 360
  361 SKDQLPSAVF YTVLNSHQGV TCAEISDDST MLACGFGDSS VRIWSLTPAK LRTLKDADSL 420
  421 RELDKESADI NVRMLDDRSG EVTRSLMGHT GPVYRCAFAP EMNLLLSCSE DSTIRLWSLL 480
  481 TWSCVVTYRG HVYPVWDVRF APHGYYFVSC SYDKTARLWA TDSNQALRVF VGHLSDVDCV 540
  541 QFHPNSNYVA TGSSDRTVRL WDNMTGQSVR LMTGHKGSVS SLAFSACGRY LASGSVDHNI 600
  601 IIWDLSNGSL VTTLLRHTST VTTITFSRDG TVLAAAGLDN NLTLWDFHKV TEDYISNHIT 660
  661 VSHHQDENDE DVYLMRTFPS KNSPFVSLHF TRRNLLMCVG LFKS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] deduced N/A No confident structure predictions are available.
    2 View Details [92..606] PSI-BLAST 72.045757 No description for 2ovpB was found.
    3 View Details [607..704] PSI-BLAST 46.69897 Actin interacting protein 1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.61142954750278 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85374902981345 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K4 specific)
    		•  3.53507344623686 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.35098520158193 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.31615347567536 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.14917998298348 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.3610959773142 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.30918780727915 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  2.28847626309518 bayes_pls_golite062009
  • protein binding
    		•  2.26925404328312 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • dynactin binding
    		•  1.92897254169098 bayes_pls_golite062009
  • DNA binding
    		•  1.71685536470455 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.61306435587568 bayes_pls_golite062009
  • transcription activator activity
    		•  1.23969853550045 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • transcription factor activity
    		•  1.08768505897883 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
    		• 0.88172763425403 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • histone binding
    		•  0.685319917508843 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.676924760416604 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.658573452658359 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  0.506092196611806 bayes_pls_golite062009
  • transcription factor binding
    		•  0.489473003915035 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.43316396073854 bayes_pls_golite062009
  • snoRNA binding
    		•  0.347797037104681 bayes_pls_golite062009
  • myosin II binding
    		•  0.33142771724387 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.311523647180993 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.30761651528651 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.28606552120995 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.251120087240234 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.231534552000461 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.182612389752591 bayes_pls_golite062009
  • chromatin binding
    		•  0.151977098745772 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • receptor binding
    		•  0.0390635451962911 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle