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View Structure Prediction Details

Protein: Taf5-PA
Organism: Drosophila melanogaster
Length: 704 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Taf5-PA.

Description E-value Query
Range
Subject
Range
gi|26354080, gi|... - gi|28893469|ref|NP_796316.1| TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated facto...
533.0 [0..17] [702..92]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEVSNING GNGTQLSHDK RELLCLLKLI KKYQLKSTEE LLCQEANVSS VELSEISESD  60
   61 VQQVLGAVLG AGDANRERKH VQSPAQGHKQ S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [92-606]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVTEANAAEE LAKFIDDDSF DAQHYEQAYK ELRTFVEDSL DIYKHELSMV LYPILVQIYF  60
   61 KILASGLREK AKEFIEKYKC DLDGYYIEGL FNLLLLSKPE ELLENDLVVA MEQDKFVIRM 120
  121 SRDSHSLFKR HIQDRRQEVV ADIVSKYLHF DTYEGMARNK LQCVATAGSH LGEAKRQDNK 180
  181 MRVYYGLLKE VDFQTLTTPA PAPEEEDDDP DAPDRPKKKK PKKDPLLSKK SKSDPNAPSI 240
  241 DRIPLPELKD SDKLLKLKAL REASKRLALS KDQLPSAVFY TVLNSHQGVT CAEISDDSTM 300
  301 LACGFGDSSV RIWSLTPAKL RTLKDADSLR ELDKESADIN VRMLDDRSGE VTRSLMGHTG 360
  361 PVYRCAFAPE MNLLLSCSED STIRLWSLLT WSCVVTYRGH VYPVWDVRFA PHGYYFVSCS 420
  421 YDKTARLWAT DSNQALRVFV GHLSDVDCVQ FHPNSNYVAT GSSDRTVRLW DNMTGQSVRL 480
  481 MTGHKGSVSS LAFSACGRYL ASGSVDHNII IWDLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.045757
Match: 2ovpB
Description: No description for 2ovpB was found.

Predicted Domain #3
Region A:
Residues: [607-704]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGSLVTTLLR HTSTVTTITF SRDGTVLAAA GLDNNLTLWD FHKVTEDYIS NHITVSHHQD  60
   61 ENDEDVYLMR TFPSKNSPFV SLHFTRRNLL MCVGLFKS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.69897
Match: 1nr0A
Description: Actin interacting protein 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.61142954750278 bayes_pls_golite062009
actin binding 3.86142918698875 bayes_pls_golite062009
acetyltransferase activity 3.85374902981345 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 3.53507344623686 bayes_pls_golite062009
acyltransferase activity 3.35098520158193 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.31615347567536 bayes_pls_golite062009
GTPase activity 3.23750443966606 bayes_pls_golite062009
transferase activity, transferring acyl groups 3.14917998298348 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
transcription initiation factor activity 2.28847626309518 bayes_pls_golite062009
protein binding 2.26925404328312 bayes_pls_golite062009
actin filament binding 2.0735069176589 bayes_pls_golite062009
dynactin binding 1.92897254169098 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.61306435587568 bayes_pls_golite062009
transcription activator activity 1.23969853550045 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
myosin binding 0.989691178611801 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
protein transporter activity 0.964340340346761 bayes_pls_golite062009
type 1 angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
0.88172763425403 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription repressor activity 0.658573452658359 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.506092196611806 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
insulin receptor binding 0.43316396073854 bayes_pls_golite062009
snoRNA binding 0.347797037104681 bayes_pls_golite062009
myosin II binding 0.33142771724387 bayes_pls_golite062009
histone methyltransferase activity 0.311523647180993 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
nucleotidyltransferase activity 0.28606552120995 bayes_pls_golite062009
structural molecule activity 0.254012051644049 bayes_pls_golite062009
G-protein-coupled receptor binding 0.251120087240234 bayes_pls_golite062009
myosin heavy chain kinase activity 0.231534552000461 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
transcription corepressor activity 0.182612389752591 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
receptor binding 0.0390635451962911 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle