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Protein Overview: Hr46-PA, FBpp0297438

General Information:
Name(s) found: FBpp0297438 [FlyBase]
Hr46-PA / FBpp0087456 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=2R:complement(6095513..6095633,6095696..6095846,6095906..6096149,6096211..6096357,6096426..6096529,6096606..6096775,6096945..6097113,6097385..6097612,6109982..6110111); ID=FBpp0297438; name=Hr46-PF; parent=FBgn0000448,FBtr0306345; dbxref=REFSEQ:NP_001246236,GB_protein:AFH07991,FlyBase:FBpp0297438,FlyBase_Annotation_IDs:CG33183-PF; MD5=ce7ee2c94f35e106bd3504b39436d9d7; length=487; release=r5.56; species=Dmel; [FlyBase]
  • The gene Hormone receptor-like in 46 is referred to in FlyBase by the symbol Dmel\Hr46 (CG33183, FBgn0000448). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:6092959..6124853. It has the cytological map location 46F5-46F7. There is experimental evidence that it has the molecular function</span>: protein binding; ligand-dependent nuclear receptor activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 54 alleles are reported. The phenotypes of these alleles are annotated with: taenidial fold; mushroom body; embryonic peripheral nervous system; adult head; puparium. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 487 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS][NAS]
    Biological Process: regulation of development, heterochronic [TAS]
    mushroom body development [IMP]
    regulation of transcription, DNA-dependent [IEA]
    metamorphosis [TAS]
    Molecular Function: transcription factor activity [ISS]
    zinc ion binding [IEA]
    protein binding [IPI]
    ligand-dependent nuclear receptor activity [IDA][ISS][NAS]
    steroid hormone receptor activity [IEA]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYTQRMFDMW SSVTSKLEAH ANNLGQSNVQ SPAGQNNSSG SIKAQIEIIP CKVCGDKSSG  60
   61 VHYGVITCEG CKGFFRRSQS SVVNYQCPRN KQCVVDRVNR NRCQYCRLQK CLKLGMSRDA 120
  121 VKFGRMSKKQ REKVEDEVRF HRAQMRAQSD AAPDSSVYDT QTPSSSDQLH HNNYNSYSGG 180
  181 YSNNEVGYGS PYGYSASVTP QQTMQYDISA DYVDSTTYEP RSTIIDPEFI SHADGDINDV 240
  241 LIKTLAEAHA NTNTKLEAVH DMFRKQPDVS RILYYKNLGQ EELWLDCAEK LTQMIQNIIE 300
  301 FAKLIPGFMR LSQDDQILLL KTGSFELAIV RMSRLLDLSQ NAVLYGDVML PQEAFYTSDS 360
  361 EEMRLVSRIF QTAKSIAELK LTETELALYQ SLVLLWPERN GVRGNTEIQR LFNLSMNAIR 420
  421 QELETNHAPL KGDVTVLDTL LNNIPNFRDI SILHMESLSK FKLQHPNVVF PALYKELFSI 480
  481 DSQQDLT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..153] PSI-BLAST 20.69897 Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter
    2 View Details [154..225] deduced N/A No confident structure predictions are available.
    3 View Details [226..487] PSI-BLAST 37.39794 Orphan nuclear receptor ROR-beta

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • vitamin D3 receptor activity
    		•  5.5563493713822 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  4.66615836207965 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • vitamin D binding
    		•  2.05947211013242 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.56146647486761 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.48246587604476 bayes_pls_golite062009
  • estrogen receptor activity
    		•  1.47290778095383 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • promoter binding
    		•  1.16363620574097 bayes_pls_golite062009
  • transcription activator binding
    		•  1.12331753119132 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • juvenile hormone binding
    		•  0.814202236506491 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.754240851368212 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
  • estrogen response element binding
    		•  4.73336420190096E-4 bayes_pls_golite062009
    3
    Term Confidence Notes
  • vitamin D3 receptor activity
    		•  5.5563493713822 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  4.81441024181511 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  4.66615836207965 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  3.91470119037087 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.83878598697109 bayes_pls_golite062009
  • hormone receptor binding
    		•  3.79647267365529 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • vitamin D binding
    		•  2.05947211013242 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.59968001933699 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.56146647486761 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.48246587604476 bayes_pls_golite062009
  • estrogen receptor activity
    		•  1.47290778095383 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.45560845709347 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.23834725221597 bayes_pls_golite062009
  • promoter binding
    		•  1.16363620574097 bayes_pls_golite062009
  • transcription activator binding
    		•  1.12331753119132 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.995333369475571 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • juvenile hormone binding
    		•  0.814202236506491 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.754240851368212 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • lipid binding
    		•  0.164046651023989 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009
  • estrogen response element binding
    		•  4.73336420190096E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle