Protein Overview: Ggamma1-PC, Ggam...

General Information:
Name(s) found:	Ggamma1-PC / FBpp0087728 [FlyBase] Ggamma1-PB / FBpp0087727 [FlyBase] Ggamma1-PA / FBpp0087726 [FlyBase]
Description(s) found: Found 68 descriptions. SHOW ALL	The gene G protein Ă?Ă?Âł 1 is referred to in FlyBase by the symbol Dmel\GĂ?Ă?Âł1 (CG8261, FBgn0004921). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4788908..4792296. It has the cytological map location 44F3-44F5. It is reported to have molecular function</span>: GTPase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; proboscis extension reflex; cell adhesion; asymmetric neuroblast division; embryonic heart tube development; actin filament organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; embryonic neuroblast; cardioblast; ganglion mother cell; embryonic pericardial cell. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene G protein Ă?Ă?Âł 1 is referred to in FlyBase by the symbol Dmel\GĂ?Ă?Âł1 (CG8261, FBgn0004921). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4788908..4792296. It has the cytological map location 44F3-44F5. It is reported to have molecular function</span>: GTPase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; proboscis extension reflex; cell adhesion; asymmetric neuroblast division; embryonic heart tube development; actin filament organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; embryonic neuroblast; cardioblast; ganglion mother cell; embryonic pericardial cell. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase] The gene G protein Ă?Ă?Âł 1 is referred to in FlyBase by the symbol Dmel\GĂ?Ă?Âł1 (CG8261, FBgn0004921). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4788908..4792296. It has the cytological map location 44F3-44F5. It is reported to have molecular function</span>: GTPase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; proboscis extension reflex; cell adhesion; asymmetric neuroblast division; embryonic heart tube development; actin filament organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: neuroblast; embryonic neuroblast; cardioblast; ganglion mother cell; embryonic pericardial cell. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	70 amino acids
Gene Ontology:
Cellular Component:	heterotrimeric G-protein complex [IEA][NAS]
Biological Process:	regulation of cell shape [IMP] proboscis extension reflex [IMP] G-protein coupled receptor protein signaling pathway [IEA][NAS] apical protein localization [TAS] actin filament organization [IMP] cell adhesion [IMP] asymmetric neuroblast division [IMP] embryonic heart tube development [IMP]
Molecular Function:	GTPase activity [NAS] signal transducer activity [IEA]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MDVMSSSLQQ QRVVVEQLRR EAAIDRQTIS ESCAKMMKYI TEHEQEDYLL TGFTSQKVNP 60 61 FREKSSCTVL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

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No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..70]	PSI-BLAST	20.522879	The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
GTPase activity	6.23138098096616	bayes_pls_golite062009
angiotensin receptor binding	2.59868793911346	bayes_pls_golite062009
type 1 angiotensin receptor binding	2.59868793911346	bayes_pls_golite062009
G-protein-coupled receptor binding	2.34916947767021	bayes_pls_golite062009
signal transducer activity	1.75801578312445	bayes_pls_golite062009
molecular transducer activity	1.75801578312445	bayes_pls_golite062009
nucleoside-triphosphatase activity	1.62723010313037	bayes_pls_golite062009
pyrophosphatase activity	1.55645551527959	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.53805916057226	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.53586893403838	bayes_pls_golite062009
binding	1.25375089530994	bayes_pls_golite062009
hydrolase activity	0.489687420983837	bayes_pls_golite062009
protein binding	0.399162858691971	bayes_pls_golite062009
receptor binding	0.38304823982539	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle