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Protein Overview: PGRP-SC2-PA

General Information:
Name(s) found: PGRP-SC2-PA / FBpp0087788 [FlyBase]
Description(s) found:
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  • gi|85692730|sp|Q9V4X2.1|PGSC2_DROME RecName: Full=Peptidoglycan-recognition protein SC2; Flags: Precursor [NCBI NR]
  • gi|7304009|gb|AAF59051.1| PGRP-SC2 [Drosophila melanogaster] [NCBI NR]
  • gi|37665341|emb|CAD89187.1| peptidoglycan recognition protein SC2 [Drosophila melanogaster] [NCBI NR]
  • gi|37665323|emb|CAD89178.1| peptidoglycan recognition protein SC2 [Drosophila melanogaster] [NCBI NR]
  • gi|37665321|emb|CAD89177.1| peptidoglycan recognition protein SC2 [Drosophila melanogaster] [NCBI NR]
  • gi|24651867|ref|NP_610410.1| PGRP-SC2 [Drosophila melanogaster] [NCBI NR]
  • Peptidoglycan-recognition protein SC2 OS=Drosophila melanogaster GN=PGRP-SC2 PE=2 SV=1 [Swiss-Prot]
  • The gene PGRP-SC2 is referred to in FlyBase by the symbol Dmel\PGRP-SC2 (CG14745, FBgn0043575). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4604472..4605026. It has the cytological map location 44E2. Based on sequence similarity, it is predicted to have molecular function</span>: peptidoglycan binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidoglycan catabolic process; innate immune response; immune response. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG14745-PA translation from_gene[CG14745 PGRP-SC2 FBgn0043575] seq_release:3 mol_weight=19830 cds_boundaries:(2R:3,777,714..3,778,265[+]) aa_length:184 transcript_info:[CG14745-RA seq_release:3] gene_info:[gene symbol:PGRP-SC2 FBgn0043575 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V4X2) CG14745 protein [DrosMelano7227.FASTAC.txt]
  • (AE003836) CG14745 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG14745-PA [Drosophila melanogaster]gi|37665341|emb|CAD89187.1| peptidoglycan recognition protein SC2 [Drosophila melanogaster]gi|37665323|emb|CAD89178.1| peptidoglycan recognition protein SC2 [Drosophila melanogaster]gi|37665321|emb|CAD89177.1| peptid [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:4604472..4605026; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051; MD5=36588e97426ae41237621c3fe [fly-100309-contam.fasta]
  • peptidoglycan recognition protein SC2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • PGRP-SC2 CG14745-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Peptidoglycan-recognition protein-SC2 precursor [nr-271106-contam.fasta]
  • CG14745-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:4604472..4605026; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:4604472..4605026; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:4604472..4605026; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051,FlyMine:FBpp0087788,modMine:FBpp0087788; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:8716967..8717521; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051,FlyMine:FBpp0087788,modMine:FBpp0087788; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:8716967..8717521; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051,FlyMine:FBpp0087788,modMine:FBpp0087788; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087788 type=protein; loc=2R:8716967..8717521; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051,FlyMine:FBpp0087788,modMine:FBpp0087788; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:8716967..8717521; ID=FBpp0087788; name=PGRP-SC2-PA; parent=FBgn0043575,FBtr0088709; dbxref=FlyBase:FBpp0087788,FlyBase_Annotation_IDs:CG14745-PA,GB_protein:AAF59051.1,REFSEQ:NP_610410,GB_protein:AAF59051,UniProt/Swiss-Prot:Q9V4X2,FlyMine:FBpp0087788,modMine:FBpp0087788; MD5=36588e97426ae41237621c3fe6467c2c; length=184; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 184 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    extracellular region [ISS]
    Biological Process: immune response [ISS]
    innate immune response [ISS]
    peptidoglycan catabolic process [ISS]
    defense response [NAS]
    Molecular Function: peptidoglycan binding [ISS][NAS]
    protein binding [IEA]
    N-acetylmuramoyl-L-alanine amidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH HTAGNYCSTK  60
   61 AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG WNVMGAHATN WNSKSIGISF 120
  121 LGNYNTNTLT SAQITAAKGL LSDAVSRGQI VSGYILYGHR QVGSTECPGT NIWNEIRTWS 180
  181 NWKA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 49.39794 Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidoglycan binding
    		•  9.32313496679335 bayes_pls_golite062009
  • peptidoglycan receptor activity
    		•  6.51660037886232 bayes_pls_golite062009
  • pattern recognition receptor activity
    		•  6.45255811818702 bayes_pls_golite062009
  • N-acetylmuramoyl-L-alanine amidase activity
    		•  5.29207604418857 bayes_pls_golite062009
  • pattern binding
    		•  4.06455798515101 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.20235326428146 bayes_pls_golite062009
  • receptor activity
    		•  2.69681086194598 bayes_pls_golite062009
  • signal transducer activity
    		•  2.24692953747972 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.24692953747972 bayes_pls_golite062009
  • binding
    		•  1.78736719382897 bayes_pls_golite062009
  • muramyl dipeptide binding
    		•  1.16811676642278 bayes_pls_golite062009
  • hydrolase activity
    		•  1.14017500144843 bayes_pls_golite062009
    		• 0.808368163500401 bayes_pls_golite062009
  • catalytic activity
    		•  0.628556091191359 bayes_pls_golite062009
    		• 0.60706691535931 bayes_pls_golite062009
  • protein binding
    		•  0.175384917086218 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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