YRC Public Data Repository - Protein Structure Prediction

Protein:	PGRP-SC2-PA
Organism:	Drosophila melanogaster
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PGRP-SC2-PA.

Description	E-value	Query Range	Subject Range
gi\|54636704, gi\|... - gi\|54636704\|gb\|EAL26107.1\| GA13217 [Drosophila pseudoobscura pseudoobscura], gi\|125810568\|ref\|XP_001... gi\|125810568\|ref... - GA13217-PA [Drosophila pseudoobscura], GA13217 [Drosophila pseudoobscura pseudoobscura]	213.0	[0..1]	[184..1]
gi\|37665329, gi\|... - gi\|37665329\|emb\|CAD89181.1\| peptidoglycan recognition protein SC2 [Drosophila melanogaster], gi\|3766...	210.0	[0..1]	[184..1]
gi\|60688419, gi\|... - gi\|71896011\|ref\|NP_001025626.1\| pglyrp1 protein [Xenopus (Silurana) tropicalis], gi\|60688419\|gb\|AAH9...	210.0	[0..4]	[184..1]
PGSC2_DROSI - Peptidoglycan-recognition protein SC2 OS=Drosophila simulans GN=PGRP-SC2 PE=3 SV=1	208.0	[0..1]	[184..1]
gi\|148236319, gi... - gi\|56269181\|gb\|AAH87429.1\| LOC496035 protein [Xenopus laevis], gi\|148236319\|ref\|NP_001088771.1\| hypo... UniRef90_D6QX30 - PGRP-S n=3 Tax=Xenopus RepID=D6QX30_XENTR	199.0	[0..6]	[184..4]
gi\|63033995 - gi\|63033995\|gb\|AAY27974.1\| peptidoglycan recognition protein 2 precursor [Euprymna scolopes]	194.0	[0..4]	[182..6]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH HTAGNYCSTK  60
   61 AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG WNVMGAHATN WNSKSIGISF 120
  121 LGNYNTNTLT SAQITAAKGL LSDAVSRGQI VSGYILYGHR QVGSTECPGT NIWNEIRTWS 180
  181 NWKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	49.39794
Match:	1s2jA
Description:	Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidoglycan binding	9.32313496679335	bayes_pls_golite062009
peptidoglycan receptor activity	6.51660037886232	bayes_pls_golite062009
pattern recognition receptor activity	6.45255811818702	bayes_pls_golite062009
N-acetylmuramoyl-L-alanine amidase activity	5.29207604418857	bayes_pls_golite062009
pattern binding	4.06455798515101	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.20235326428146	bayes_pls_golite062009
receptor activity	2.69681086194598	bayes_pls_golite062009
signal transducer activity	2.24692953747972	bayes_pls_golite062009
molecular transducer activity	2.24692953747972	bayes_pls_golite062009
binding	1.78736719382897	bayes_pls_golite062009
muramyl dipeptide binding	1.16811676642278	bayes_pls_golite062009
hydrolase activity	1.14017500144843	bayes_pls_golite062009
	0.808368163500401	bayes_pls_golite062009
catalytic activity	0.628556091191359	bayes_pls_golite062009
	0.60706691535931	bayes_pls_golite062009
protein binding	0.175384917086218	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: