Protein Overview: PGRP-SC2-PA

General Information:
Name(s) found:	PGRP-SC2-PA / FBpp0087788 [FlyBase]
Description(s) found: Found 25 descriptions. SHOW ALL	The gene PGRP-SC2 is referred to in FlyBase by the symbol Dmel\PGRP-SC2 (CG14745, FBgn0043575). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4604472..4605026. It has the cytological map location 44E2. Based on sequence similarity, it is predicted to have molecular function</span>: peptidoglycan binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidoglycan catabolic process; innate immune response; immune response. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	184 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [NAS] extracellular region [ISS]
Biological Process:	immune response [ISS] innate immune response [ISS] peptidoglycan catabolic process [ISS] defense response [NAS]
Molecular Function:	peptidoglycan binding [ISS][NAS] protein binding [IEA] N-acetylmuramoyl-L-alanine amidase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANKALILLA VLFCAQAVLG VTIISKSEWG GRSATSKTSL ANYLSYAVIH HTAGNYCSTK  60
   61 AACITQLQNI QAYHMDSLGW ADIGYNFLIG GDGNVYEGRG WNVMGAHATN WNSKSIGISF 120
  121 LGNYNTNTLT SAQITAAKGL LSDAVSRGQI VSGYILYGHR QVGSTECPGT NIWNEIRTWS 180
  181 NWKA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
peptidoglycan binding	9.32313496679335	bayes_pls_golite062009
peptidoglycan receptor activity	6.51660037886232	bayes_pls_golite062009
pattern recognition receptor activity	6.45255811818702	bayes_pls_golite062009
N-acetylmuramoyl-L-alanine amidase activity	5.29207604418857	bayes_pls_golite062009
pattern binding	4.06455798515101	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.20235326428146	bayes_pls_golite062009
receptor activity	2.69681086194598	bayes_pls_golite062009
signal transducer activity	2.24692953747972	bayes_pls_golite062009
molecular transducer activity	2.24692953747972	bayes_pls_golite062009
binding	1.78736719382897	bayes_pls_golite062009
muramyl dipeptide binding	1.16811676642278	bayes_pls_golite062009
hydrolase activity	1.14017500144843	bayes_pls_golite062009
	0.808368163500401	bayes_pls_golite062009
catalytic activity	0.628556091191359	bayes_pls_golite062009
	0.60706691535931	bayes_pls_golite062009
protein binding	0.175384917086218	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..184]	PSI-BLAST	49.39794	Crystal structure of the Drosophila pattern-recognition receptor PGRP-SA

Protein Overview: PGRP-SC2-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: