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Protein Overview: Pabp2-PA, Pabp2-PB

General Information:
Name(s) found: Pabp2-PB / FBpp0087864 [FlyBase]
Pabp2-PA / FBpp0087863 [FlyBase]
Description(s) found:
Found 43 descriptions.
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  • The gene Pabp2 is referred to in FlyBase by the symbol Dmel\Pabp2 (CG2163, FBgn0005648). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4018918..4021879. It has the cytological map location 44B3. There is experimental evidence that it has the molecular function</span>: RNA binding; poly(A) RNA binding. There is experimental evidence that it is involved in the biological process</span>: mRNA polyadenylation; nuclear-transcribed mRNA poly(A) tail shortening. 18 alleles are reported. The phenotype of these alleles is annotated with: chorion. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Pabp2 is referred to in FlyBase by the symbol Dmel\Pabp2 (CG2163, FBgn0005648). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4018918..4021879. It has the cytological map location 44B3. There is experimental evidence that it has the molecular function</span>: RNA binding; poly(A) RNA binding. There is experimental evidence that it is involved in the biological process</span>: mRNA polyadenylation; nuclear-transcribed mRNA poly(A) tail shortening. 18 alleles are reported. The phenotype of these alleles is annotated with: chorion. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][ISS]
    catalytic step 2 spliceosome [IDA]
    cytoplasm [IDA]
    precatalytic spliceosome [IDA]
    Biological Process: mRNA polyadenylation [IDA][IMP][ISS]
    nuclear-transcribed mRNA poly(A) tail shortening [IMP]
    nuclear mRNA splicing, via spliceosome [IC]
    Molecular Function: nucleotide binding [IEA]
    RNA binding [IDA]
    poly(A) RNA binding [IDA][ISS]
    mRNA binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADEDITLNE DQLLESLEET NGEQETEIAT EVEEEGSMQI DPELEAIKAR VKEMEEEAEK  60
   61 IKQMQSEVDK QMAGGSTTGL ATVPLSLEEK QEIDTRSVYV GNVDYGASAE ELEAHFHGCG 120
  121 TINRVTILCN KADGHPKGFA YIEFGSKEFV ETALAMNETL FRGRQIKVMS KRTNRPGLST 180
  181 TNRFARGSFR GRGARVSRAC CHSTFRGARR AMGYRGRANY YAPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..224] PSI-BLAST 37.154902 Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(6-MI)G); A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6-MI)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  5.15097136329571 bayes_pls_golite062009
  • mRNA binding
    		•  4.05281507540116 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
    		• 2.60920363363072 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  1.36691748240059 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • protein binding
    		•  0.42571879933058 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
  • hydrolase activity
    		•  0.153089401492248 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle