Protein Overview: sax-PA

General Information:
Name(s) found:	sax-PA / FBpp0087908 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7304152\|gb\|AAF59189.1\| saxophone, isoform A [Drosophila melanogaster] [NCBI NR] gi\|642862\|gb\|AAA61946.1\| receptor protein serine/threonine kinase [NCBI NR] gi\|24586379\|ref\|NP_523652.2\| saxophone, isoform A [Drosophila melanogaster] [NCBI NR] The gene saxophone is referred to in FlyBase by the symbol Dmel\sax (CG1891, FBgn0003317). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3693983..3697575. It has the cytological map location 43E18. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor activity, type I. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; regulation of biological process; multicellular organism reproduction; regulation of developmental process; gamete generation; ovarian follicle cell development; organ development; regionalization; positive regulation of cellular component biogenesis; anterior/posterior axis specification; actin filament-based process. 40 alleles are reported. The phenotypes of these alleles are annotated with 34 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; peripheral nervous system; germarium; egg; external compound sense organ; embryonic/larval tracheal system; extended germ band embryo; nervous system; imaginal precursor; cell component. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG1891-PA translation from_gene[CG1891 sax FBgn0003317] seq_release:3 mol_weight=64229 cds_boundaries:(2R:2,867,439..2,870,317[+]) aa_length:570 transcript_info:[CG1891-RA seq_release:3] gene_info:[gene symbol:sax FBgn0003317 gene_boundaries:(2R:2,867 [hmr_yeast5_DM3-1_pombe.fasta] (Q27931) Serine/threonine-protein kinase receptor SAXOPHONE [DrosMelano7227.FASTAC.txt] (AE003839) sax gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG1891-PA, isoform A [Drosophila melanogaster]gi\|24586379\|ref\|NP_523652.2\| CG1891-PA [Drosophila melanogaster]gi\|642862\|gb\|AAA61946.1\| receptor protein serine/threonine kinase [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:join(3694043..3694103,3694577..3694706,3695074..3695149,3695213..3695871,3696015..3696425,3696487..3696712,3696775..3696924); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_I [fly-100309-contam.fasta] CG1891-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] saxophone CG1891-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] receptor protein serine/threonine kinase [nr-271106-contam.fasta] type=protein; loc=2R:join(3694043..3694103,3694577..3694706,3695074..3695149,3695213..3695871,3696015..3696425,3696487..3696712,3696775..3696924); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:join(3694043..3694103,3694577..3694706,3695074..3695149,3695213..3695871,3696015..3696425,3696487..3696712,3696775..3696924); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Receptor protein serine/threonine kinase OS=Drosophila melanogaster GN=sax PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:join(3694043..3694103,3694577..3694706,3695074..3695149,3695213..3695871,3696015..3696425,3696487..3696712,3696775..3696924); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189,FlyMine:FBpp0087908,modMine:FBpp0087908; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Receptor protein serine/threonine kinase OS=Drosophila melanogaster GN=sax PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=2R:join(7806538..7806598,7807072..7807201,7807569..7807644,7807708..7808366,7808510..7808920,7808982..7809207,7809270..7809419); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189,FlyMine:FBpp0087908,modMine:FBpp0087908; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:join(7806538..7806598,7807072..7807201,7807569..7807644,7807708..7808366,7808510..7808920,7808982..7809207,7809270..7809419); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189,FlyMine:FBpp0087908,modMine:FBpp0087908; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A0A0B4K7J3, Receptor protein serine/threonine kinase OS=Drosophila melanogaster GN=sax PE=1 SV=1 [DROME.fasta.20160308] FBpp0087908 type=protein; loc=2R:join(7806538..7806598,7807072..7807201,7807569..7807644,7807708..7808366,7808510..7808920,7808982..7809207,7809270..7809419); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189,FlyMine:FBpp0087908,modMine:FBpp0087908; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:join(7806538..7806598,7807072..7807201,7807569..7807644,7807708..7808366,7808510..7808920,7808982..7809207,7809270..7809419); ID=FBpp0087908; name=sax-PA; parent=FBgn0003317,FBtr0088832; dbxref=FlyBase:FBpp0087908,FlyBase_Annotation_IDs:CG1891-PA,GB_protein:AAF59189.1,REFSEQ:NP_523652,GB_protein:AAF59189,UniProt/TrEMBL:Q7JQ36,FlyMine:FBpp0087908,modMine:FBpp0087908; MD5=3234502cd361d57c81c2462b76b73da7; length=570; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	570 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] plasma membrane [ISS]
Biological Process:	transforming growth factor beta receptor signaling pathway [ISS][NAS] imaginal disc-derived wing morphogenesis [IMP] ovarian nurse cell to oocyte transport [TAS] actin filament organization [IMP] germ-line stem cell division [IMP] decapentaplegic receptor signaling pathway [IGI][IMP] chorion-containing eggshell formation [IGI] protein amino acid phosphorylation [IEA][NAS] anterior/posterior pattern formation, imaginal disc [IMP] positive regulation of synaptic growth at neuromuscular junction [IMP] maternal determination of anterior/posterior axis, embryo [IGI][IMP] dorsal/ventral pattern formation [IGI][IMP] negative regulation of BMP signaling pathway [IMP] oogenesis [IMP] compound eye morphogenesis [NAS] BMP signaling pathway [TAS] ovarian follicle cell development [IMP][TAS] germ-line stem cell maintenance [IMP]
Molecular Function:	ATP binding [IEA] protein kinase activity [NAS] protein serine/threonine kinase activity [NAS] transforming growth factor beta receptor activity, type I [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESNIYLVFL LTFLLYNNAR AEISDHLRED IPDLDMELSS ASSAHLNGKE LPAVPQNSVQ  60
   61 THPRYKCYSC EPPCRDPYEF THTCQNAIQC WKSRTRDADG QVQESRGCST SPDQLPMICS 120
  121 QNSLKINGPS KRNTGKFVNV VCCAGDYCNE GDFPELLPFD SNDVTVITAD TSSISKMLVA 180
  181 VLGPFLVIAL LGAVTIFFIR RSHRKRLAAS RTKQDPEAYL VNDELLRATS AGDSTLREYL 240
  241 QHSVTSGSGS GLPLLVQRTL AKQVTLIECI GRGKYGEVWR GHWHGESIAV KIFFSRDEES 300
  301 WKRETEIYST ILLRHENILG FIGSDMTSRN SCTQLWLMTH YYPLGSLFDH LNRNALSHND 360
  361 MVWICLSIAN GLVHLHTEIF GKQGKPAMAH RDLKSKNILV TSNGSCVIAD FGLAVTHSHV 420
  421 TGQLDLGNNP KVGTKRYMAP EVLDESIDLE CFEALRRTDI YAFGLVLWEV CRRTISCGIA 480
  481 EEYKVPFYDV VPMDPSFEDM RKVVCIDNYR PSIPNRWSSD SLMTGMSKLM KECWHQNPDV 540
  541 RLPALRIKKT IHKLASADEK IRLDFDEVCV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..202]	PSI-BLAST	7.522879	Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
2	View Details	[203..570]	PSI-BLAST	76.154902	Type I TGF-beta receptor R4

Protein Overview: sax-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: