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Protein Overview: sax-PA

General Information:
Name(s) found: sax-PA / FBpp0087908 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene saxophone is referred to in FlyBase by the symbol Dmel\sax (CG1891, FBgn0003317). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3693983..3697575. It has the cytological map location 43E18. There is experimental evidence that it has the molecular function</span>: transforming growth factor beta receptor activity, type I. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; regulation of biological process; multicellular organism reproduction; regulation of developmental process; gamete generation; ovarian follicle cell development; organ development; regionalization; positive regulation of cellular component biogenesis; anterior/posterior axis specification; actin filament-based process. 40 alleles are reported. The phenotypes of these alleles are annotated with 34 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; peripheral nervous system; germarium; egg; external compound sense organ; embryonic/larval tracheal system; extended germ band embryo; nervous system; imaginal precursor; cell component. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 570 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    plasma membrane [ISS]
    Biological Process: transforming growth factor beta receptor signaling pathway [ISS][NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    ovarian nurse cell to oocyte transport [TAS]
    actin filament organization [IMP]
    germ-line stem cell division [IMP]
    decapentaplegic receptor signaling pathway [IGI][IMP]
    chorion-containing eggshell formation [IGI]
    protein amino acid phosphorylation [IEA][NAS]
    anterior/posterior pattern formation, imaginal disc [IMP]
    positive regulation of synaptic growth at neuromuscular junction [IMP]
    maternal determination of anterior/posterior axis, embryo [IGI][IMP]
    dorsal/ventral pattern formation [IGI][IMP]
    negative regulation of BMP signaling pathway [IMP]
    oogenesis [IMP]
    compound eye morphogenesis [NAS]
    BMP signaling pathway [TAS]
    ovarian follicle cell development [IMP][TAS]
    germ-line stem cell maintenance [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [NAS]
    transforming growth factor beta receptor activity, type I [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESNIYLVFL LTFLLYNNAR AEISDHLRED IPDLDMELSS ASSAHLNGKE LPAVPQNSVQ  60
   61 THPRYKCYSC EPPCRDPYEF THTCQNAIQC WKSRTRDADG QVQESRGCST SPDQLPMICS 120
  121 QNSLKINGPS KRNTGKFVNV VCCAGDYCNE GDFPELLPFD SNDVTVITAD TSSISKMLVA 180
  181 VLGPFLVIAL LGAVTIFFIR RSHRKRLAAS RTKQDPEAYL VNDELLRATS AGDSTLREYL 240
  241 QHSVTSGSGS GLPLLVQRTL AKQVTLIECI GRGKYGEVWR GHWHGESIAV KIFFSRDEES 300
  301 WKRETEIYST ILLRHENILG FIGSDMTSRN SCTQLWLMTH YYPLGSLFDH LNRNALSHND 360
  361 MVWICLSIAN GLVHLHTEIF GKQGKPAMAH RDLKSKNILV TSNGSCVIAD FGLAVTHSHV 420
  421 TGQLDLGNNP KVGTKRYMAP EVLDESIDLE CFEALRRTDI YAFGLVLWEV CRRTISCGIA 480
  481 EEYKVPFYDV VPMDPSFEDM RKVVCIDNYR PSIPNRWSSD SLMTGMSKLM KECWHQNPDV 540
  541 RLPALRIKKT IHKLASADEK IRLDFDEVCV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202] PSI-BLAST 7.522879 Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor
    2 View Details [203..570] PSI-BLAST 76.154902 Type I TGF-beta receptor R4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pattern binding
    		•  0.21003196804615 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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