YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: mus205-PA

General Information:
Name(s) found: mus205-PA / FBpp0087907 [FlyBase]
Description(s) found:
SHOW ONLY BEST
  • gi|24586371|ref|NP_524881.2| mutagen-sensitive 205 [Drosophila melanogaster] [NCBI NR]
  • gi|21627721|gb|AAF59191.2| mutagen-sensitive 205 [Drosophila melanogaster] [NCBI NR]
  • gi|11096179|gb|AAG30224.1| DNA polymerase zeta catalytic subunit [Drosophila melanogaster] [NCBI NR]
  • The gene mutagen-sensitive 205 is referred to in FlyBase by the symbol Dmel\mus205 (CG1925, FBgn0002891). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3680757..3688549. It has the cytological map location 43E17. There is experimental evidence that it has the molecular function</span>: DNA-directed DNA polymerase activity. It is reported to be involved in the biological process</span>: DNA replication; translesion synthesis. 11 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG1925-PA translation from_gene[CG1925 mus205 FBgn0002891] seq_release:3 mol_weight=240076 cds_boundaries:(2R:2,854,597..2,861,656[+]) aa_length:2130 transcript_info:[CG1925-RA seq_release:3] gene_info:[gene symbol:mus205 FBgn0002891 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9GSR1) DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (CG1925 protein) [DrosMelano7227.FASTAC.txt]
  • CG1925-PA [Drosophila melanogaster]gi|24586371|ref|NP_524881.2| CG1925-PA [Drosophila melanogaster]gi|11096179|gb|AAG30224.1| DNA polymerase zeta catalytic subunit [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(3681201..3681332,3681391..3681620,3681678..3681922,3681980..3682227,3682286..3682730,3682800..3682916,3682979..3683383,3683441..3683525,3683591..3683677,3683736..3686423,3686489..3687583,3687648..3688263); ID=FBpp0087907; name=mu [fly-100309-contam.fasta]
  • CG1925-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • mutagen-sensitive 205 CG1925-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • DNA polymerase zeta catalytic subunit [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(3681201..3681332,3681391..3681620,3681678..3681922,3681980..3682227,3682286..3682730,3682800..3682916,3682979..3683383,3683441..3683525,3683591..3683677,3683736..3686423,3686489..3687583,3687648..3688263); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(3681201..3681332,3681391..3681620,3681678..3681922,3681980..3682227,3682286..3682730,3682800..3682916,3682979..3683383,3683441..3683525,3683591..3683677,3683736..3686423,3686489..3687583,3687648..3688263); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • DNA polymerase OS=Drosophila melanogaster GN=mus205 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(3681201..3681332,3681391..3681620,3681678..3681922,3681980..3682227,3682286..3682730,3682800..3682916,3682979..3683383,3683441..3683525,3683591..3683677,3683736..3686423,3686489..3687583,3687648..3688263); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191,FlyMine:FBpp0087907,modMine:FBpp0087907; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(7793696..7793827,7793886..7794115,7794173..7794417,7794475..7794722,7794781..7795225,7795295..7795411,7795474..7795878,7795936..7796020,7796086..7796172,7796231..7798918,7798984..7800078,7800143..7800758); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191,FlyMine:FBpp0087907,modMine:FBpp0087907; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(7793696..7793827,7793886..7794115,7794173..7794417,7794475..7794722,7794781..7795225,7795295..7795411,7795474..7795878,7795936..7796020,7796086..7796172,7796231..7798918,7798984..7800078,7800143..7800758); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191,FlyMine:FBpp0087907,modMine:FBpp0087907; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • DNA polymerase OS=Drosophila melanogaster GN=mus205 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0087907 type=protein; loc=2R:join(7793696..7793827,7793886..7794115,7794173..7794417,7794475..7794722,7794781..7795225,7795295..7795411,7795474..7795878,7795936..7796020,7796086..7796172,7796231..7798918,7798984..7800078,7800143..7800758); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191,FlyMine:FBpp0087907,modMine:FBpp0087907; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(7793696..7793827,7793886..7794115,7794173..7794417,7794475..7794722,7794781..7795225,7795295..7795411,7795474..7795878,7795936..7796020,7796086..7796172,7796231..7798918,7798984..7800078,7800143..7800758); ID=FBpp0087907; name=mus205-PA; parent=FBgn0002891,FBtr0088831; dbxref=FlyBase:FBpp0087907,FlyBase_Annotation_IDs:CG1925-PA,GB_protein:AAF59191.2,REFSEQ:NP_524881,GB_protein:AAF59191,UniProt/TrEMBL:Q9GSR1,FlyMine:FBpp0087907,modMine:FBpp0087907; MD5=93c3659b9766ababc0a8db6dda691e2b; length=2130; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 2130 amino acids

    Gene Ontology:
    Cellular Component: zeta DNA polymerase complex [ISS][NAS]
    Biological Process: DNA replication [IEA][NAS]
    translesion synthesis [NAS]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleotide binding [IEA]
    DNA binding [IEA]
    [NOT]3'-5' exonuclease activity [IDA]
    DNA-directed DNA polymerase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAGEAIDG VYSVRLVIAD FYMEKPQFGM DPCYSELRGK EIKRVPVIRV FGGNSRGQKT  60
   61 CMHVHGVFPY LYIPYDKKDF ESLERGILQM AMHLDKAINI SLGQGSSNAQ HVFKIQLVKG 120
  121 IPFYGYHRVE HQFLKIYMFN PRFVRRAANL LQSGAILSKN FSPHESHVPY ILQFMIDYNL 180
  181 YGMSYVHVPL EVLKFRRNHD DDVIPYANVK QAQLLDITTA KKVACSALEV DVSSNFILNR 240
  241 FQLVAKSKSN HTNPGIEAIW NDEKLRRQKL VEKHTDAGDE EKAEAVPVLE LPPTQERHQI 300
  301 EIAESDIFYR TALESKLMTL EQSTLSEQTL SDQTILPQAT MQTTMPGTKA QKRRFNLQKL 360
  361 LANAVYPEEC SQDQQQLLVN ASFIQNHVTC GYSSSVSLST SKDESDDLDE TVVDEELILS 420
  421 LTQPHGAIPH DATLREEDLE LLDALQLLEE QNESESHVDL DSSLAPLSQH KKFELTPELL 480
  481 DKETAATAAL FDEDVDSDED ADQETRHDFS TVLDDVDELL LKLTQSQPAE SKELKASSKL 540
  541 PQIDGADDRL QRTPIKSISS KSKSSPSKTP TTPIGQKSLP KSPRTPKTSA AKKYAPLALT 600
  601 IGSSSSKKSN DEFAGRPSNP RLSLQLDQGT GTGTLRPEIS LRKKLAMSEM RRKSFEDSFV 660
  661 LLKNDCTPVR STRRSTSNLD KTHIICSLTP RDRNPGLSDM FETEDGKQLP PKKVVRKTRW 720
  721 STRNQDIESL PKAGCEIERP HRSEGSALDE LKPRRSARHK VNSANPDECS SEIQTTGPRV 780
  781 TTTSLDRPQK KARLSQSPKE NTKTSMNGTV ALEKATKDSS SNSESPHQQE NSVSEQIEYL 840
  841 ESKPKKSDET ARSCDEKLQR ELIPQEPAGI SPGDSANSTE EITFSPCHDE AIESDTESDY 900
  901 IVTKLRKTPN LKRLRWSIRS ELLNKQFTPS SGIRPPETET TPQLSPKSNE SNTPELMRSF 960
  961 YEHSLIVNSP SVFSDFLDSP EIHMDSPRSA PPSPDSNSFV IAPLELPPSY DEVVSGSRKM1020
 1021 DIPEYEFQKP YYSNPSDVSK VTEVGFLVLH IPGNKLNDCD PFQSILGNDR GLASWRRRQL1080
 1081 IAIGGLAMLQ RHRGEQKVRE YFSTQQRIAI EPAQLAPTWQ EAKIWLKAKE LLRQREEPKK1140
 1141 SSDDIDSPIK IKRQKITMML QAEEGDGGSG DEDAGEELDC SLSLTPLSQA KDKCKATPTS1200
 1201 SKARETGKSR LKRGTRLSFI GSQDEEPPSS QSSEQSVSSS AAQAELDRSS FLRQLEGSSQ1260
 1261 DRQHDLSFGL SHATLDNTFG FKVNLENLQQ AKADIDCNHL TIITLEVFVS TRGDLQPDPM1320
 1321 HDEIRCLFYA IEHSLPDEKL PSKACGYIMV NTVQDLLSEG PFHGIDRDIE VQVVTSEAEA1380
 1381 FEALLALCER WDADIYAGYE IEMSSWGYVI DRAKHLCFNI APLLSRVPTQ KVRDFVDEDR1440
 1441 EQFTDLDVEM KLCGRILLDV WRLMRSEIAL TSYTFENVMY HILHKRCPWH TAKSLTEWFG1500
 1501 SPCTRWIVME YYLERVRGTL TLLDQLDLLG RTSEMAKLIG IQFYEVLSRG SQFRVESMML1560
 1561 RIAKPKNLVP LSPSVQARAH MRAPEYLALI MEPQSRFYAD PLIVLDFQSL YPSMIIAYNY1620
 1621 CFSTCLGRVE HLGGSSPFEF GASQLRVSRQ MLQKLLEHDL VTVSPCGVVF VKREVREGIL1680
 1681 PRMLTEILDT RQMVKQSMKL HKDSSALQRI LHSRQLGLKL MANVTYGYTA ANFSGRMPSV1740
 1741 EVGDSVVSKG RETLERAIKL VENNEEWKVR VVYGDTDSMF VLVPGRNRAE AFRIGEEIAK1800
 1801 AVTEMNPQPV KLKLEKVYQP CMLQTKKRYV GYMYETADQE QPVYEAKGIE TVRRDGCPAV1860
 1861 AKMLEKVLRI LFETQDVSKI KAYVCRQFTK LLSGRANLQD LIFAKEFRGL NGYKPTACVP1920
 1921 ALELTRKWMQ KDPRHVPRRG ERVPFIIVNG PPGMQLIRLV RSPHDILANE GHKINAIYYI1980
 1981 TKAIIPPLNR CLLLIGANVH DWFASLPRKL LMTPAVGTAN ELAGARGAKS TISQYFSTTS2040
 2041 CVIDCGRQTK AGICPDCLKN ATTCVVVLSD KTARLERGYQ LTRQICQACC GRLGSLQCDS2100
 2101 LDCPVLYVLE GKRRELQQIE HWNKLLEHHF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] FFAS03 1.66 Crystal structure of ESCHERICHIA coli DNA Polymerase II
    2 View Details [252..362] deduced N/A No confident structure predictions are available.
    3 View Details [363..554] deduced N/A No confident structure predictions are available.
    4 View Details [555..997] FFAS03 1.24 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    5 View Details [998..1159] deduced N/A No confident structure predictions are available.
    6 View Details [1160..2019] PSI-BLAST 173.0 Exonuclease domain of family B (archaeal and phage) DNA polymerases; T4-like DNA polymerase
    7 View Details [2020..2130] FFAS03 1.0 No description for 2cklB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  11.2781960093187 bayes_pls_golite062009
  • DNA polymerase activity
    		•  11.2285838712952 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  8.85826259809475 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.79232184185512 bayes_pls_golite062009
  • transferase activity
    		•  4.02382113115178 bayes_pls_golite062009
  • DNA primase activity
    		•  1.77742223999604 bayes_pls_golite062009
  • exonuclease activity
    		•  1.42205333874102 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.41033617404868 bayes_pls_golite062009
  • RNA polymerase activity
    		•  1.16960098510532 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  1.16960098510532 bayes_pls_golite062009
  • catalytic activity
    		•  1.04899053677564 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.959511000267266 bayes_pls_golite062009
  • endonuclease activity
    		•  0.935348031740788 bayes_pls_golite062009
  • DNA binding
    		•  0.86778938742546 bayes_pls_golite062009
  • binding
    		•  0.808919229163124 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.39441061793492 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.14466215642144 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.126013788737514 bayes_pls_golite062009
  • protein binding
    		•  0.101829155879905 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.0700154911930899 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.0662718964590603 bayes_pls_golite062009
  • nuclease activity
    		•  0.0574785418962505 bayes_pls_golite062009
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle