Protein Overview: Cul-3-PE, Cul-3-...

General Information:
Name(s) found:	Cul-3-PE / FBpp0291368 [FlyBase] Cul-3-PC / FBpp0291367 [FlyBase] Cul-3-PD / FBpp0291366 [FlyBase]
Description(s) found: Found 49 descriptions. SHOW ALL	The gene Cullin-3 is referred to in FlyBase by the symbol Dmel\Cul-3 (CG42616, FBgn0261268). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:15266029..15272011. It has the cytological map location 35C5. It is reported to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: activation of caspase activity; sensory organ development; dendrite morphogenesis; sperm individualization; imaginal disc-derived wing morphogenesis; axonogenesis; protein ubiquitination. 32 alleles are reported. The phenotypes of these alleles are annotated with: sensillum campaniformium; wing margin bristle; anterior crossvein; wing vein L4; spermatid; wing hair. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene Cullin-3 is referred to in FlyBase by the symbol Dmel\Cul-3 (CG42616, FBgn0261268). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:15266029..15272011. It has the cytological map location 35C5. It is reported to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: activation of caspase activity; sensory organ development; dendrite morphogenesis; sperm individualization; imaginal disc-derived wing morphogenesis; axonogenesis; protein ubiquitination. 32 alleles are reported. The phenotypes of these alleles are annotated with: sensillum campaniformium; wing margin bristle; anterior crossvein; wing vein L4; spermatid; wing hair. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase] The gene Cullin-3 is referred to in FlyBase by the symbol Dmel\Cul-3 (CG42616, FBgn0261268). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:15266029..15272011. It has the cytological map location 35C5. It is reported to have molecular function</span>: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: activation of caspase activity; sensory organ development; dendrite morphogenesis; sperm individualization; imaginal disc-derived wing morphogenesis; axonogenesis; protein ubiquitination. 32 alleles are reported. The phenotypes of these alleles are annotated with: sensillum campaniformium; wing margin bristle; anterior crossvein; wing vein L4; spermatid; wing hair. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	773 amino acids
Gene Ontology:
Cellular Component:	nuclear ubiquitin ligase complex [ISS] SCF ubiquitin ligase complex [NAS] Cul3-RING ubiquitin ligase complex [IPI]
Biological Process:	sperm individualization [IMP] compound eye morphogenesis [NAS] axonogenesis [IMP] regulation of proteolysis [NAS] imaginal disc-derived wing morphogenesis [IMP] activation of caspase activity [IMP] sensory organ development [IMP] ubiquitin-dependent protein catabolic process [IEA] dendrite morphogenesis [IMP] protein ubiquitination [IMP]
Molecular Function:	ubiquitin-protein ligase activity [NAS] ubiquitin protein ligase binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLRGNPPKK EGKMRIRAFP ASMDEKYVET IWASLKNAIQ EIQKKNNSGL SFEQLYRNAY  60
   61 NMVLHKHGNR LYYGLREVVS EHLEHKVRAD VLEALHSNFL PKLNQAWTDH QTSMVMIRDI 120
  121 LMYMDRVYVQ QREVDNVYNL GLILFRDQVV RYSEIQKALR EKLLGMVMEE RHGEAINHLA 180
  181 IKNACSMLIT LGINSRTVYE EDFEKPFLAQ SAAFYKFESQ NFLAENNAGV YIKKVEARIT 240
  241 EESSRAALYL DKDTEPRIVR VVEEELIKKH MRPIVEMENS GVVYMIKNSK TEDLACTYKL 300
  301 FSRLKEEGLK VIADTMSAYL REQGRMLVKE EENGNTNPIT FVQNLLDLKD RFDQFLVHSF 360
  361 ANDRIFKNVI SSDFEHFLNL NNKSPEYLSL FIDDKLKKGG KGMSEQEIES ILDKTMVLFR 420
  421 FLLEKDVFER YYKTHLAKRL LLNKSVSDDF EKNMISKLKT ECGCQFTSKL EGMFKDMSVS 480
  481 NTIMDEFKNF VNNNNLSLGG VELTVRILTT GFWPTQTATP NCNIPAAPRE AFDIFKNFYL 540
  541 NKHSGRQLTL QPQMGTAYIN AVFYGRKAVE SEKDKDAPSS SSSGCGVPTT TRKHILQVST 600
  601 YQMCVLLLFN NRDVLTYDDI HQETDIPERE LVRALQSLSM GKPAQRLLVR NSKTKTKDIE 660
  661 PTDEFYVNDA FNSKFHRVKI QTVAAKGESE PERKETRGKV DEDRKHEIEA AIVRIMKARK 720
  721 RLAHNLLVSD VTSQLKSRFL PSPVFIKKRI EGLIEREYLQ RSPEDRKVYN YLA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Cul-3-PE, Cul-3-...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: