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Protein Overview: Prosalpha6T-PA

General Information:
Name(s) found: Prosalpha6T-PA / FBpp0080028 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Proteasome Ã?&#142;Ã?±6T subunit is referred to in FlyBase by the symbol Dmel\ProsÃ?&#142;Ã?±6T (CG5648, FBgn0032492). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:13232039..13233059. It has the cytological map location 34A11. Based on sequence similarity, it is predicted to have molecular function</span>: endopeptidase activity. There is experimental evidence that it is involved in the biological process</span>: cellular response to DNA damage stimulus; sperm individualization; spermatid nucleus elongation. 4 alleles are reported. The phenotypes of these alleles are annotated with: cystic bulge; spermatozoon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 289 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    proteasome core complex [ISS][NAS]
    proteasome core complex, alpha-subunit complex [IEA]
    cytosol [IDA]
    male germ cell nucleus [IDA]
    Biological Process: spermatid nucleus elongation [IMP]
    sperm individualization [IMP]
    response to DNA damage stimulus [IMP]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: endopeptidase activity [ISS][NAS]
    threonine-type endopeptidase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRNQYDNDT TTWSPQGRLF QVEYAMEAVK QGAATVGLKG TDYAVLAALC RTSKDTNTLQ  60
   61 RKIMPVDDHV GMSIAGLTAD ARVVCQYMRT ECMAYRHSYN AEFPVRRLVS NLGNKLQTTT 120
  121 QRYDRRPYGV GLLVAGYDEQ GPHIYQVMPT ANVLNCKAMA IGSRSQSART YLERNMESFE 180
  181 DCDMDELICH AIQAIRGSLG SDDVENLTIN VAIVGKDVPF KMFTEAENQK YVKLVKAMDP 240
  241 PLEADHDPLS EEGMSDDDMT DHGPSSSGVP PNDTSDMETT ASTGGSDAH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..289] PSI-BLAST 65.69897 Proteasome alpha subunit (non-catalytic)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endopeptidase activity
    		•  6.91642761177919 bayes_pls_golite062009
  • peptidase activity
    		•  6.84511694091156 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.5973571808298 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47652590304822 bayes_pls_golite062009
  • threonine-type endopeptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • threonine-type peptidase activity
    		•  2.98214579292788 bayes_pls_golite062009
  • binding
    		•  1.75265921676176 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39216781236247 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle