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Protein Overview: Ppt2-PA

General Information:
Name(s) found: Ppt2-PA / FBpp0079801 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Palmitoyl-protein Thioesterase 2 is referred to in FlyBase by the symbol Dmel\Ppt2 (CG4851, FBgn0032358). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:11280314..11281929. It has the cytological map location 32E2. Based on sequence similarity, it is predicted to have molecular function</span>: palmitoyl-(protein) hydrolase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein modification process. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 288 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein modification process [IEA]
    Molecular Function: palmitoyl-(protein) hydrolase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLRLQVLVA LLTCSSISVS LAYKPVVILH GILSGAESMA SLVREIEEFH PGTIVYNCDK  60
   61 FNGWYSLENA WRQVDQVRDY LNEVGKLHPE GIIVLGYSQG GLLARAAIQS LPEHNVKTFI 120
  121 SLSSPQAGQY GTSFLHLIFP DLAAKTAFEL FYSRVGQHTS VGGYWNDPQR QDLYLKYSEF 180
  181 LPLINNEKKT SNSTSFKMGM VRLNKLVMIG GPNDDVITPW QSSHFGYFDE NMDVIPFIRR 240
  241 PIFTSDSIGI RTLQEAGKLI IVVKPHVHHL AWHTRRDVIH EVIFPYLD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..288] PSI-BLAST 56.39794 The crystal structure of palmitoyl protein thioesterase-2 reveals the basis for divergent substrate specificities of the two lysosomal thioesterases (PPT1 and PPT2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • palmitoyl-(protein) hydrolase activity
    		•  7.84854320744165 bayes_pls_golite062009
  • hydrolase activity
    		•  4.09944423676394 bayes_pls_golite062009
  • peptidase activity
    		•  2.579037452232 bayes_pls_golite062009
  • acetylcholinesterase activity
    		•  2.37279517515601 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  2.35941833736344 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.29616929491964 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.11440496336538 bayes_pls_golite062009
  • carboxylesterase activity
    		•  2.10340684157921 bayes_pls_golite062009
  • lipase activity
    		•  1.95656432876646 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.74304544475032 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.55367000864476 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • acyl-CoA thioesterase activity
    		•  1.04921581031052 bayes_pls_golite062009
  • binding
    		•  0.978846093152455 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.90303666778029 bayes_pls_golite062009
  • protein binding
    		•  0.890384359682543 bayes_pls_golite062009
  • receptor binding
    		•  0.845720597560984 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.73146656929653 bayes_pls_golite062009
  • cholinesterase activity
    		•  0.4381742778062 bayes_pls_golite062009
  • acylglycerol lipase activity
    		•  0.345658974420231 bayes_pls_golite062009
  • heparin binding
    		•  0.140386417117496 bayes_pls_golite062009
  • phospholipase activity
    		•  0.1336535306364 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.120715665971321 bayes_pls_golite062009
  • triglyceride lipase activity
    		•  0.05324087110088 bayes_pls_golite062009
  • juvenile hormone epoxide hydrolase activity
    		•  0.0481017624758091 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00117419779800387 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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