YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Su(var)205-PB, S...

General Information:
Name(s) found: Su(var)205-PB / FBpp0079252 [FlyBase]
Su(var)205-PA / FBpp0079251 [FlyBase]
Description(s) found:
Found 59 descriptions.
SHOW ALL
  • The gene Suppressor of variegation 205 is referred to in FlyBase by the symbol Dmel\Su(var)205 (CG8409, FBgn0003607). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:8209626..8211133. It has the cytological map location 28F2-28F3. There is experimental evidence that it has the molecular function</span>: satellite DNA binding; rDNA binding; chromatin binding. There is experimental evidence that it is involved in the biological process</span>: regulation of apoptosis; regulation of histone methylation; establishment of chromatin silencing; telomere maintenance; chromosome organization; regulation of transcription; chromatin silencing at centromere; histone H4-K20 trimethylation; chromatin silencing. 77 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; dorsal mesothoracic disc; chromosome, telomeric region; neuroblast; mitotic cell cycle; polytene chromosome; imaginal disc; larval optic lobe; melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Suppressor of variegation 205 is referred to in FlyBase by the symbol Dmel\Su(var)205 (CG8409, FBgn0003607). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:8209626..8211133. It has the cytological map location 28F2-28F3. There is experimental evidence that it has the molecular function</span>: satellite DNA binding; rDNA binding; chromatin binding. There is experimental evidence that it is involved in the biological process</span>: regulation of apoptosis; regulation of histone methylation; establishment of chromatin silencing; telomere maintenance; chromosome organization; regulation of transcription; chromatin silencing at centromere; histone H4-K20 trimethylation; chromatin silencing. 77 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; dorsal mesothoracic disc; chromosome, telomeric region; neuroblast; mitotic cell cycle; polytene chromosome; imaginal disc; larval optic lobe; melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 206 amino acids

    Gene Ontology:
    Cellular Component: polytene chromosome chromocenter [IDA][TAS]
    condensed chromosome [IDA]
    nucleus [IDA][NAS]
    chromosome, telomeric region [IDA][NAS]
    heterochromatin [IDA][NAS][TAS]
    polytene chromosome, telomeric region [IDA][TAS]
    polytene chromosome puff [IDA][TAS]
    condensed nuclear chromosome, centromeric region [IDA]
    chromosome [IDA]
    chromosome, centromeric region [NAS][TAS]
    centromeric heterochromatin [NAS]
    nuclear heterochromatin [IDA]
    Biological Process: regulation of histone methylation [IMP]
    chromatin silencing at centromere [IMP]
    negative regulation of transcription, DNA-dependent [NAS]
    positive regulation of transcription, DNA-dependent [TAS]
    chromosome organization [IMP]
    establishment of chromatin silencing [IMP]
    chromatin assembly or disassembly [IEA]
    telomere maintenance [IMP]
    regulation of apoptosis [IMP]
    chromatin silencing [IMP]
    histone H4-K20 trimethylation [IMP]
    regulation of transcription [IMP]
    Molecular Function: histone binding [NAS]
    methylated histone residue binding [TAS]
    rDNA binding [IDA]
    mRNA binding [NAS]
    chromatin binding [IDA][ISS]
    transcription activator activity [TAS]
    transcription repressor activity [NAS]
    satellite DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKIDNPES SAKVSDAEEE EEEYAVEKII DRRVRKGKVE YYLKWKGYPE TENTWEPENN  60
   61 LDCQDLIQQY EASRKDEEKS AASKKDRPSS SAKAKETQGR ASSSTSTASK RKSEEPTAPS 120
  121 GNKSKRTTDA EQDTIPVSGS TGFDRGLEAE KILGASDNNG RLTFLIQFKG VDQAEMVPSS 180
  181 VANEKIPRMV IHFYEERLSW YSDNED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] PSI-BLAST 9.221849 Heterochromatin protein 1, HP1
    2 View Details [78..206] PSI-BLAST 23.045757 No description for 2fmmA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle