Protein Overview: wg-PA

General Information:
Name(s) found:	wg-PA / FBpp0079060 [FlyBase]
Description(s) found: Found 24 descriptions. SHOW ALL	The gene wingless is referred to in FlyBase by the symbol Dmel\wg (CG4889, FBgn0004009). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:7307161..7316255. It has the cytological map location 27F1. There is experimental evidence that it has the molecular function</span>: frizzled-2 binding; protein binding. There is experimental evidence for 32 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; regulation of developmental process; organ morphogenesis; cell projection organization; regulation of biological process; cell projection assembly; positive regulation of cell proliferation; positive regulation of programmed cell death; embryonic pattern specification; reproductive process in a multicellular organism; actin filament-based process; microspike assembly; regulation of metabolic process. 228 alleles are reported. The phenotypes of these alleles are annotated with 207 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; peripheral nervous system; nervous system; primordium; embryonic nervous system; late extended germ band embryo; abdominal ventral denticle belt; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	468 amino acids
Gene Ontology:
Cellular Component:	early endosome [IDA] membrane raft [IDA] late endosome [IDA] cytoplasmic membrane-bounded vesicle [NAS] extracellular region [IEA][NAS][TAS]
Biological Process:	anterior head segmentation [TAS] posterior head segmentation [TAS] dorsal/ventral pattern formation, imaginal disc [TAS] epidermis development [IMP][NAS] mesoderm development [NAS] negative regulation of cell fate specification [IMP] imaginal disc-derived wing margin morphogenesis [NAS] regulation of transcription [IMP] instar larval development [TAS] anti-apoptosis [TAS] compound eye morphogenesis [IMP] ovarian follicle cell development [TAS] Wnt receptor signaling pathway [NAS] cell fate specification [TAS] spiracle morphogenesis, open tracheal system [IMP] wing cell fate specification [IMP] ommatidial rotation [TAS] anterior/posterior axis specification, embryo [NAS][TAS] Wnt receptor signaling pathway, calcium modulating pathway [IDA][IGI] epithelial cell fate determination, open tracheal system [TAS] proboscis development [IMP] regulation of mitotic cell cycle [TAS] sensory organ development [TAS] open tracheal system development [TAS] ventral midline development [IMP] ventral cord development [TAS] positive regulation of compound eye retinal cell programmed cell death [IMP] mesoderm morphogenesis [IMP] genital disc anterior/posterior pattern formation [IEP] determination of genital disc primordium [IMP] actin filament bundle assembly [IMP] dorsal closure [IMP][TAS] wing disc development [IGI] wing disc morphogenesis [NAS] wing disc proximal/distal pattern formation [TAS] blastoderm segmentation [NAS] genital disc sexually dimorphic development [IMP] dorsal closure, elongation of leading edge cells [IMP] positive regulation of cell proliferation [IGI] imaginal disc-derived wing morphogenesis [IMP][NAS] ectoderm development [NAS] pericardial cell differentiation [IMP] leg disc proximal/distal pattern formation [NAS][TAS] wing disc anterior/posterior pattern formation [TAS] heart development [TAS] lymph gland development [IMP] labial disc development [IMP] genital disc development [TAS] cuticle pattern formation [IMP] foregut morphogenesis [TAS] segment polarity determination [IMP][NAS][TAS] trunk segmentation [TAS] imaginal disc development [IMP] hindgut morphogenesis [IMP][TAS] imaginal disc pattern formation [NAS][TAS] compound eye development [TAS] filopodium assembly [IMP] regulation of cell proliferation [NAS] negative regulation of phosphorylation [NAS] imaginal disc growth [TAS] larval visceral muscle development [IMP] regulation of transcription from RNA polymerase II promoter [TAS] regulation of compound eye pigmentation [IMP] lamellipodium assembly [IMP] wing disc dorsal/ventral pattern formation [TAS] cardioblast differentiation [IMP]
Molecular Function:	protein binding [IDA] frizzled-2 binding [IDA][IGI][NAS] Notch binding [TAS] receptor binding [NAS] signal transducer activity [IEA][TAS] morphogen activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDISYIFVIC LMALCSGGSS LSQVEGKQKS GRGRGSMWWG IAKVGEPNNI TPIMYMDPAI  60
   61 HSTLRRKQRR LVRDNPGVLG ALVKGANLAI SECQHQFRNR RWNCSTRNFS RGKNLFGKIV 120
  121 DRGCRETSFI YAITSAAVTH SIARACSEGT IESCTCDYSH QSRSPQANHQ AGSVAGVRDW 180
  181 EWGGCSDNIG FGFKFSREFV DTGERGRNLR EKMNLHNNEA GRAHVQAEMR QECKCHGMSG 240
  241 SCTVKTCWMR LANFRVIGDN LKARFDGATR VQVTNSLRAT NALAPVSPNA AGSNSVGSNG 300
  301 LIIPQSGLVY GEEEERMLND HMPDILLENS HPISKIHHPN MPSPNSLPQA GQRGGRNGRR 360
  361 QGRKHNRYHF QLNPHNPEHK PPGSKDLVYL EPSPSFCEKN LRQGILGTHG RQCNETSLGV 420
  421 DGCGLMCCGR GYRRDEVVVV ERCACTFHWC CEVKCKLCRT KKVIYTCL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: wg-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: