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Protein Overview: KIME_RAT

General Information:
Name(s) found: KIME_RAT [Swiss-Prot]
Description(s) found:
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  • gi|205378|gb|AAA41588.1| mevalonate kinase (EC 2.7.1.36) [NCBI NR]
  • gi|20151083|pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian Mevalonate Kinase And Atp: Insights Into The Reaction Mechanism And Human Inherited Disease [NCBI NR]
  • gi|192988178|pdb|2R42|A Chain A, The Biochemical And Structural Basis For Feedback Inhibition Of Mevalonate Kinase And Isoprenoid Metabolism [NCBI NR]
  • gi|149063614|gb|EDM13937.1| mevalonate kinase, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13592007|ref|NP_112325.1| mevalonate kinase [Rattus norvegicus] [NCBI NR]
  • gi|125406|sp|P17256.1|KIME_RAT RecName: Full=Mevalonate kinase; Short=MK [NCBI NR]
  • pir||A35629 mevalonate kinase (EC 2.7.1.36) [validated] - rat [NCBI NR]
  • Mevalonate kinase OS=Rattus norvegicus GN=Mvk PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Mevalonate kinase [hmr_yeast5_DM3-1_pombe.fasta]
  • mevalonate kinase [HMR_022704-rand.fasta]
  • mevalonate kinase [Rattus norvegicus]gi|111959|pir||A35629 mevalonate kinase (EC 2.7.1.36) [validated] - ratgi|20151083|pdb|1KVK|A Chain A, The Structure Of Binary Complex Between A Mammalian Mevalonate Kinase And Atp: Insights Into The Reaction Mechani [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Mevalonate kinase [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031063) mevalonate kinase [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Chain A, The Biochemical And Structural Basis For Feedback Inhibition Of Mevalonate Kinase And Isoprenoid Metabolism [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Chain A, The Structure Of Binary Complex Between A Mammalian Mevalonate Kinase And Atp: Insights Into The Reaction Mechanism And Human Inherited Disease [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Mevalonate kinase (MK) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mevalonate kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mevalonate kinase, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mevalonate kinase (EC 2.7.1.36) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 MEVALONATE KINASE [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Mvk Mevalonate kinase [rat-ipi-250309-contam.fasta]
  • Mevalonate kinase OS=Rattus norvegicus GN=Mvk [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 395 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDA]
    soluble fraction [IDA]
    cytoplasm [IEA]
    cytosol [IDA]
    Biological Process: regulation of cholesterol biosynthetic process [NAS]
    isopentenyl diphosphate biosynthetic process, mevalonate pathway [IDA]
    metabolic process [IEA]
    cholesterol biosynthetic process [TAS]
    isoprenoid biosynthetic process [UNKNOWN][IDA]
    phosphorylation [IEA]
    sterol metabolic process [TAS]
    negative regulation of translation [IDA]
    isoprenoid metabolic process [TAS]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA]
    identical protein binding [UNKNOWN]
    mRNA binding [IDA]
    mevalonate kinase activity [UNKNOWN][IDA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSEVLLVSA PGKVILHGEH AVVHGKVALA VALNLRTFLV LRPQSNGKVS LNLPNVGIKQ  60
   61 VWDVATLQLL DTGFLEQGDV PAPTLEQLEK LKKVAGLPRD CVGNEGLSLL AFLYLYLAIC 120
  121 RKQRTLPSLD IMVWSELPPG AGLGSSAAYS VCVAAALLTA CEEVTNPLKD RGSIGSWPEE 180
  181 DLKSINKWAY EGERVIHGNP SGVDNSVSTW GGALRYQQGK MSSLKRLPAL QILLTNTKVP 240
  241 RSTKALVAGV RSRLIKFPEI MAPLLTSIDA ISLECERVLG EMAAAPVPEQ YLVLEELMDM 300
  301 NQHHLNALGV GHASLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLER AKVEAAKQAL 360
  361 TGCGFDCWET SIGAPGVSMH SATSIEDPVR QALGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..395] PSI-BLAST 71.39794 Mevalonate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.57444343595083 bayes_pls_golite062009
  • kinase activity
    		•  2.45533953107206 bayes_pls_golite062009
  • diphosphomevalonate decarboxylase activity
    		•  2.34245588421319 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.31269308415192 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.15678581504347 bayes_pls_golite062009
  • structural molecule activity
    		•  1.96296069933386 bayes_pls_golite062009
  • binding
    		•  1.9197744309809 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90728659801871 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.75408506104351 bayes_pls_golite062009
  • DNA binding
    		•  1.50208874269692 bayes_pls_golite062009
  • transferase activity
    		•  1.44847475955289 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  0.49664490095304 bayes_pls_golite062009
  • mRNA binding
    		•  0.396503273803591 bayes_pls_golite062009
  • sugar binding
    		•  0.28452694121194 bayes_pls_golite062009
  • mevalonate kinase activity
    		•  0.196672422286181 bayes_pls_golite062009
  • protein binding
    		•  0.191135371876197 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.69

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle