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Protein Overview: LYN_RAT

General Information:
Name(s) found: LYN_RAT [Swiss-Prot]
Description(s) found:
Found 23 descriptions.
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  • Tyrosine-protein kinase Lyn OS=Rattus norvegicus GN=Lyn PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 512 amino acids

    Gene Ontology:
    Cellular Component: postsynaptic density [IDA]
    mitochondrial crista [IDA]
    Golgi apparatus [UNKNOWN][IEA]
    plasma membrane [UNKNOWN][IDA]
    membrane fraction [IDA]
    nucleus [UNKNOWN][ISS]
    mitochondrial intermembrane space [IDA]
    mitochondrial membrane [IDA]
    perinuclear region of cytoplasm [IDA][IEA]
    cytoplasm [ISS]
    cell-cell adherens junction [IDA]
    intracellular membrane-bounded organelle [UNKNOWN]
    membrane raft [UNKNOWN][IDA]
    alpha2-beta1 integrin complex [IDA]
    cytosol [UNKNOWN]
    Biological Process: oligodendrocyte development [IEP]
    peptidyl-tyrosine phosphorylation [UNKNOWN][IEA]
    positive regulation of cell proliferation [ISS]
    response to amino acid stimulus [IEP]
    protein amino acid autophosphorylation [UNKNOWN][IEA]
    positive regulation of cellular component movement [UNKNOWN][IEA]
    response to axon injury [IEP]
    positive regulation of tyrosine phosphorylation of STAT protein [ISS]
    response to toxin [IEP]
    positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
    response to insulin stimulus [IEP]
    cellular response to heat [IEP]
    response to protein stimulus [IEP]
    positive regulation of stress-activated protein kinase signaling pathway [UNKNOWN][IEA]
    positive regulation of oligodendrocyte progenitor proliferation [IMP]
    B cell receptor signaling pathway [UNKNOWN][IEA]
    positive regulation of phosphorylation [IMP]
    neuron projection development [UNKNOWN]
    positive regulation of glial cell proliferation [IDA]
    response to carbohydrate stimulus [IEP]
    response to sterol depletion [IEP]
    response to organic cyclic substance [IEP]
    response to DNA damage stimulus [UNKNOWN][IEA]
    response to hormone stimulus [ISS]
    response to peptide hormone stimulus [IEP]
    histamine secretion by mast cell [IMP]
    cytokine secretion [IMP]
    regulation of release of sequestered calcium ion into cytosol [IMP]
    cellular response to extracellular stimulus [IEP]
    intracellular signaling pathway [UNKNOWN][IEA]
    erythrocyte differentiation [ISS]
    response to drug [IEP]
    Molecular Function: glycosphingolipid binding [IPI]
    platelet-derived growth factor receptor binding [IPI]
    protein kinase activity [UNKNOWN]
    integrin binding [IDA]
    gamma-tubulin binding [IDA]
    receptor binding [IPI]
    nucleotide binding [IEA]
    ATP binding [IEA]
    protein tyrosine kinase activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    ubiquitin protein ligase binding [IPI]
    non-membrane spanning protein tyrosine kinase activity [IEA]
    phosphoprotein binding [IPI]
    SH3 domain binding [UNKNOWN][IEA]
    transferase activity [IEA]
    protein complex binding [UNKNOWN][IDA]
    kinase activity [TAS]
    enzyme binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCIKSKRKD NLNDDGVDMK TQPVRNTDRT IYVRDPTSNK QQRPVPESQL LPGQRFQAKD  60
   61 PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM KVLEEHGEWW KAKSLSSKRE GFIPSNYVAK 120
  121 VNTLETEEWF FKDITRKDAE RQLLAPGNSA GAFLIRESET LKGSFSLSVR DYDPMHGDVI 180
  181 KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQSDGLCR RLEKACISPK PQKPWDKDAW 240
  241 EIPRESIKLV KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSAQAFLEE ANLMKTLQHD 300
  301 KLVRLYAVVT KEEPIYIITE FMAKGSLLDF LKSDEGSKVL LPKLIDFSAQ IAEGMAYIER 360
  361 KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF 420
  421 TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPD ELYDIMKMCW 480
  481 KESAEERPTF DYLQSVLDDF YTATEGQYQQ QP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle