Protein Overview: M3K12_RAT

General Information:
Name(s) found:	M3K12_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6981716\|ref\|NP_037187.1\| mitogen-activated protein kinase kinase kinase 12 [Rattus norvegicus] [NCBI NR] gi\|18202599\|sp\|Q63796.1\|M3K12_RAT RecName: Full=Mitogen-activated protein kinase kinase kinase 12; AltName: Full=Mixed lineage kinase; AltName: Full=Leucine-zipper protein kinase; Short=ZPK; AltName: Full=Dual leucine zipper bearing kinase; Short=DLK; Alt [NCBI NR] gi\|1208444\|dbj\|BAA08621.1\| protein kinase [Rattus norvegicus] [NCBI NR] (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.1.37) (MAPK-upstream kinase) (MUK) [Swiss-Prot] Mitogen-activated protein kinase kinase kinase 12 OS=Rattus norvegicus GN=Map3k12 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):7-131912508 Mitogen-activated protein kinase kinase kinase 12 [hmr_yeast5_DM3-1_pombe.fasta] mitogen activated protein kinase kinase kinase 12; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); Zipper (leucine) protein kinase [HMR_022704-rand.fasta] mitogen activated protein kinase kinase kinase 12 [Rattus norvegicus]gi\|18202599\|sp\|Q63796\|M3KC_RAT Mitogen-activated protein kinase kinase kinase 12 (MAPK-upstream kinase) (MUK)gi\|1208444\|dbj\|BAA08621.1\| Protein kinase (MUK) [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Mitogen-activated protein kinase kinase kinase 12 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_013055) Zipper (leucine) protein kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Mitogen-activated protein kinase kinase kinase 12 (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] protein kinase [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] mitogen activated protein kinase kinase kinase 12 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] mitogen-activated protein kinase kinase kinase 12 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Protein kinase (MUK) [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Map3k12 Mitogen-activated protein kinase kinase kinase 12 [rat-ipi-250309-contam.fasta] Mitogen-activated protein kinase kinase kinase 12 OS=Rattus norvegicus GN=Map3k12 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	888 amino acids
Gene Ontology:
Cellular Component:	growth cone [UNKNOWN][IEA] cytoplasm [IEA] cytosol [ISS] axon part [UNKNOWN][IEA] plasma membrane [ISS]
Biological Process:	histone phosphorylation [ISS] protein amino acid autophosphorylation [ISS] protein amino acid phosphorylation [UNKNOWN][ISS] peptidyl-serine phosphorylation [ISS] peptidyl-threonine phosphorylation [ISS]
Molecular Function:	nucleotide binding [IEA] magnesium ion binding [IEA] ATP binding [IEA] protein kinase binding [UNKNOWN] protein binding [UNKNOWN] protein homodimerization activity [ISS] MAP kinase kinase kinase activity [IEA] protein serine/threonine kinase activity [ISS] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG  60
   61 GGPSPSPGGE PPPEPFANSV LQLHEQDTGG PGGATGSPES RASRVRADEV RLQCQSGSGF 120
  121 LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180
  181 EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240
  241 VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300
  301 MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360
  361 HLPVPSSCPD GFKILLRQCW NRKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420
  421 EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480
  481 LQLELKEREL LRREQALERR CPGLLKSHTS RSLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540
  541 ILKTESLLPK LDAALSGVGL PGCPKAPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 600
  601 PHEPGGLGSP GGLGVGPTAW DASPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 660
  661 GARDPGSPPP PQGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGEGVGL LGTGREGTTG 720
  721 RGGSRAGYQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELPPSQR WPQGPNMRQS 780
  781 LSTFSSENPS DVEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDLPTSEV 840
  841 VPERETSSLP MQHQDDQGPN PEDSDCDSTE LDNSNSIDAL PPPASLPP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Protein Overview: M3K12_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: