Protein Overview: MERL_RAT

General Information:
Name(s) found:	MERL_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|32363191\|sp\|Q63648.1\|MERL_RAT RecName: Full=Merlin; AltName: Full=Moesin-ezrin-radixin-like protein; AltName: Full=Neurofibromin-2; AltName: Full=Schwannomin [NCBI NR] gi\|1432160\|gb\|AAC13318.1\| merlin [Rattus norvegicus] [NCBI NR] Merlin (Fragment) OS=Rattus norvegicus GN=Nf2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):14-75982044 Merlin [hmr_yeast5_DM3-1_pombe.fasta] merlin [Rattus norvegicus]gi\|32363191\|sp\|Q63648\|MERL_RAT Merlin (Schwannomin) (Neurofibromin 2) [nrdb_11152004_Chlamydomonas] Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomin) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] merlin [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Merlin (Fragment) OS=Rattus norvegicus GN=Nf2 [011711_HMR.fasta] Merlin (Fragment) OS=Rattus norvegicus GN=Nf2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	586 amino acids
Gene Ontology:
Cellular Component:	cleavage furrow [UNKNOWN] protein complex [IDA] synapse [IDA] nucleolus [UNKNOWN] cell projection [IEA] plasma membrane [UNKNOWN][IDA] nucleus [UNKNOWN] insoluble fraction [IDA] early endosome [UNKNOWN] adherens junction [UNKNOWN] soluble fraction [IDA] cytoskeleton [IEA] perinuclear region of cytoplasm [UNKNOWN][IDA] cytoplasm [UNKNOWN][IDA][IEA] membrane raft [IDA] ruffle [UNKNOWN] filopodium [UNKNOWN] extrinsic to membrane [IEA] lamellipodium [UNKNOWN]
Biological Process:	regulation of hippo signaling pathway [UNKNOWN] negative regulation of tyrosine phosphorylation of Stat3 protein [UNKNOWN] Schwann cell proliferation [UNKNOWN] negative regulation of MAPKKK cascade [UNKNOWN] negative regulation of cell proliferation [UNKNOWN] negative regulation of cell-cell adhesion [UNKNOWN] odontogenesis of dentine-containing tooth [UNKNOWN] ectoderm development [UNKNOWN] negative regulation of DNA replication [UNKNOWN] negative regulation of protein kinase activity [UNKNOWN] regulation of cell proliferation [UNKNOWN] cell-cell junction organization [UNKNOWN] negative regulation of JAK-STAT cascade [UNKNOWN] negative regulation of tyrosine phosphorylation of Stat5 protein [UNKNOWN] negative regulation of cell growth [IDA][NAS] positive regulation of stress fiber assembly [UNKNOWN] mesoderm formation [UNKNOWN] lens fiber cell differentiation [UNKNOWN] actin cytoskeleton organization [UNKNOWN]
Molecular Function:	protein domain specific binding [IPI] protein binding [UNKNOWN][IPI] integrin binding [IPI] beta-catenin binding [IPI] binding [IEA] cytoskeletal protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IASRMSFSSL KRKQPKTFTV RIVTMDAEME FNCEMKWKGK DLFDLVCRTL GLRETWFFGL  60
   61 QYTIKDTVAW LKMDKKVLDH DVSKEEPVTF HFLAKFYPEN AEEELVQEIT QHLFFLQVKK 120
  121 QILDEKVYCP PEASVLLASY AVQAKYGDYD PSVHKRGFLA QEELLPKRVI NLYQMTPEMW 180
  181 EERITAWYAE HRGRARDEAE MEYLKIAQDL EMYGVNYFTI RNKKGTELLL GVDALGLHIY 240
  241 DPENRLTPKI SFPWNEIRNI SYSDKEFTIK PLDKKIDVFK FNSSKLRVNK LILQLCIGNH 300
  301 DLFMRRRKAD SLEVQQMKAQ AREEKARKQM ERQRLAREKQ MREEAERSRD EPERRVLHMK 360
  361 EEATMANEAL MRSEETADLL AEKAQITEEE AKLLAQKAAE AEQEMQRIKA TAIRTEEEKR 420
  421 LMEQKVLEAE VLALKMAEES ERRAKEADQL KQDLQEAREA ERRAKQKLLE IATKPTYPPM 480
  481 NPIPAPLPPD IPSFDIIGDS LSFDFKDTDM KRLSMEIEKE KVEYMEKSKH LQEQLNELKT 540
  541 EIEALKLKER ETALDILHSE HSDSGTSSKH NTIKKPQAQG RRPICI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MERL_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: