Protein Overview: CYTA_RAT

General Information:
Name(s) found:	CYTA_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|UDRTS2 cystatin A [validated] - rat [NCBI NR] gi\|27666704\|ref\|XP_213617.1\| PREDICTED: similar to Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [Rattus norvegicus] [NCBI NR] gi\|157786796\|ref\|NP_001099347.1\| stefin A3 [Rattus norvegicus] [NCBI NR] gi\|149060569\|gb\|EDM11283.1\| stefin A3 (predicted) [Rattus norvegicus] [NCBI NR] gi\|118178\|sp\|P01039.1\|CYTA_RAT RecName: Full=Cystatin-A; AltName: Full=Cystatin-alpha; AltName: Full=Epidermal stefin; AltName: Full=Epidermal thiol proteinase inhibitor [NCBI NR] gi\|109494443\|ref\|XP_001070663.1\| PREDICTED: similar to Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [Rattus norvegicus] [NCBI NR] Cystatin-A OS=Rattus norvegicus GN=Csta PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):11-22345266 Cystatin alpha [hmr_yeast5_DM3-1_pombe.fasta] similar to Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [HMR_022704-rand.fasta] similar to Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [Rattus norvegicus]gi\|58079\|emb\|CAA31613.1\| unnamed protein product [synthetic construct]gi\|118178\|sp\|P01039\|CYTA_RAT Cystatin alpha (Epidermal thiol prote [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Cystatin alpha [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Cystatin-A (Cystatin-alpha) (Epidermal stefin) (Epidermal thiol proteinase inhibitor) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] stefin A3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] stefin A3 (predicted) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 CYSTATIN ALPHA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] PREDICTED: similar to Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [Rattus norvegicus] [nr-271106-contam.fasta] Cystatin alpha (Epidermal thiol proteinase inhibitor) (Stefin, epidermal) (Cystatin A) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Stfa3;Csta Cystatin-A [rat-ipi-250309-contam.fasta] Cystatin-A OS=Rattus norvegicus GN=Csta [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	103 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN] cornified envelope [UNKNOWN] cytoplasm [UNKNOWN][IEA] intracellular [IEA]
Biological Process:	keratinocyte differentiation [UNKNOWN] peptide cross-linking [UNKNOWN] negative regulation of peptidase activity [UNKNOWN]
Molecular Function:	cysteine-type endopeptidase inhibitor activity [UNKNOWN][IEA] structural molecule activity [UNKNOWN] protease binding [UNKNOWN] protein binding, bridging [UNKNOWN]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MDPGTTGIVG GVSEAKPATP EIQEVADKVK RQLEEKTNEK YEKFKVVEYK SQVVAGQILF 60 61 MKVDVGNGRF LHMKVLRGLS GDDDLKLLDY QTNKTKNDEL TDF

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..103]	PSI-BLAST	35.69897	SOLUTION NMR STRUCTURE OF RECOMBINANT HUMAN CYSTATIN A UNDER THE CONDITION OF PH 3.8 AND 310K

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
protease binding	3.05816171871392	bayes_pls_golite062009
binding	1.98021211698364	bayes_pls_golite062009
enzyme inhibitor activity	1.95903133061911	bayes_pls_golite062009
enzyme binding	1.4394131270763	bayes_pls_golite062009
cysteine-type endopeptidase inhibitor activity	1.22451594457354	bayes_pls_golite062009
protein binding	0.823288035712675	bayes_pls_golite062009
structural molecule activity	0.605570282689207	bayes_pls_golite062009
endopeptidase inhibitor activity	0.502159706024347	bayes_pls_golite062009
enzyme regulator activity	0.479748849334581	bayes_pls_golite062009
peptidase inhibitor activity	0.4067124652673	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle