Protein Overview: CXA1_RAT

General Information:
Name(s) found:	CXA1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|S00532 gap junction protein Cx43 - rat [NCBI NR] gi\|6978896\|ref\|NP_036699.1\| gap junction protein, alpha 1 [Rattus norvegicus] [NCBI NR] gi\|55979\|emb\|CAA29855.1\| unnamed protein product [Rattus norvegicus] [NCBI NR] gi\|51859470\|gb\|AAH81842.1\| Gap junction protein, alpha 1 [Rattus norvegicus] [NCBI NR] ref\|XP_346605.1\| hypothetical protein XP_346604 [Rattus norvegicus] [NCBI NR] gi\|32816617\|gb\|AAP88589.1\| gap junction membrane channel protein alpha1 [Rattus norvegicus] [NCBI NR] gi\|225953\|prf\|\|1404339A connexin 43 [NCBI NR] gi\|149038621\|gb\|EDL92910.1\| gap junction membrane channel protein alpha 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|149038620\|gb\|EDL92909.1\| gap junction membrane channel protein alpha 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|149038619\|gb\|EDL92908.1\| gap junction membrane channel protein alpha 1, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|117708\|sp\|P08050.2\|CXA1_RAT RecName: Full=Gap junction alpha-1 protein; AltName: Full=Connexin-43; Short=Cx43; AltName: Full=Gap junction 43 kDa heart protein [NCBI NR] Gap junction alpha-1 protein OS=Rattus norvegicus GN=Gja1 PE=1 SV=2 [Swiss-Prot] Ensembl_locations(Chr-bp):20-32827019 gap junction membrane channel protein alpha 1 [hmr_yeast5_DM3-1_pombe.fasta] hypothetical protein XP_346604 [HMR_022704-rand.fasta] gap junction membrane channel protein alpha 1; gap junction protein, alpha 1, 43 kD; connexin 43 [HMR_022704-rand.fasta] gap junction membrane channel protein alpha 1; gap junction protein, alpha 1, 43 kD; connexin 43; Gap junction protein alpha 1 43 kD (connexin 43); gap junction protein alpha 1 43 kD [071204_hmrz_cont.fasta] hypothetical protein XP_346604 [Rattus norvegicus]gi\|6978896\|ref\|NP_036699.1\| gap junction membrane channel protein alpha 1 [Rattus norvegicus]gi\|32816617\|gb\|AAP88589.1\| gap junction membrane channel protein alpha1 [Rattus norvegicus]gi\|51859470\|gb\|AAH [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Gap junction membrane channel protein alpha1 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_012567) gap junction protein, alpha 1, 43 kD (connexin 43) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Gap junction alpha-1 protein (Connexin-43) (Cx43) (Gap junction 43 kDa heart protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Gap junction protein, alpha 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] gap junction protein, alpha 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] gap junction membrane channel protein alpha 1, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] gap junction membrane channel protein alpha1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] connexin 43 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 GAP JUNCTION MEMBRANE CHANNEL PROTEIN ALPHA 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Gap junction membrane channel protein alpha 1 [Rattus norvegicus] [nr-271106-contam.fasta] gap junction membrane channel protein alpha 1 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Gja1 Gap junction alpha-1 protein [rat-ipi-250309-contam.fasta] Gap junction alpha-1 protein OS=Rattus norvegicus GN=Gja1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	382 amino acids
Gene Ontology:
Cellular Component:	late endosome [IDA] Golgi membrane [UNKNOWN] endoplasmic reticulum [IMP] Golgi apparatus [IDA] multivesicular body [IDA] mitochondrial outer membrane [IDA] plasma membrane [UNKNOWN][IDA] lysosome [IDA] endoplasmic reticulum membrane [UNKNOWN] gap junction [UNKNOWN][IDA] integral to plasma membrane [TAS] early endosome [IDA] cell-cell junction [UNKNOWN] connexon complex [IDA][TAS] cytoplasm [IDA] fascia adherens [IDA] membrane raft [IDA] Golgi-associated vesicle membrane [UNKNOWN] cytosol [UNKNOWN] cell junction [UNKNOWN][IEA]
Biological Process:	cell communication [IMP] negative regulation of cell proliferation [IDA] positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN] neuron projection morphogenesis [IMP] blood vessel morphogenesis [UNKNOWN] adult heart development [UNKNOWN] skeletal muscle tissue regeneration [UNKNOWN] positive regulation of striated muscle tissue development [UNKNOWN] heart development [UNKNOWN][IEA] neuron migration [UNKNOWN] in utero embryonic development [UNKNOWN] apoptosis [UNKNOWN][IMP] heart looping [UNKNOWN] regulation of calcium ion transport [IMP] ATP transport [IMP] vascular transport [IMP] epithelial cell maturation [UNKNOWN] limb bud formation [UNKNOWN] cell-cell signaling [UNKNOWN][IDA][IMP] regulation of heart contraction [UNKNOWN] positive regulation of protein catabolic process [IDA] response to pH [IDA] embryonic heart tube development [UNKNOWN] response to peptide hormone stimulus [IEP] negative regulation of gene expression [UNKNOWN] positive regulation of gene expression [UNKNOWN] gap junction assembly [TAS] protein oligomerization [IDA]
Molecular Function:	protein domain specific binding [IDA] protein binding [UNKNOWN][IPI] transmembrane transporter activity [IEA] PDZ domain binding [IPI] gap junction channel activity [UNKNOWN][IDA][TAS] SH3 domain binding [IPI] signal transducer activity [UNKNOWN] receptor binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG  60
   61 CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG 120
  121 VNVEMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSVFEVAFL LIQWYIYGFS 180
  181 LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV 240
  241 KGRSDPYHAT TGPLSPSKDC GSPKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN 300
  301 YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNAKKVAAG HELQPLAIVD 360
  361 QRPSSRASSR ASSRPRPDDL EI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: CXA1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: