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Protein Overview: PP1A_RAT

General Information:
Name(s) found: PP1A_RAT [Swiss-Prot]
Description(s) found:
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  • gi|49065778|sp|P62138.1|PP1A_RAT RecName: Full=Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Short=PP-1A [NCBI NR]
  • gi|47683037|gb|AAH70517.1| Protein phosphatase 1, catalytic subunit, alpha isoform [Rattus norvegicus] [NCBI NR]
  • gi|227433|prf||1703469A protein phosphatase 1 alpha [NCBI NR]
  • gi|220867|dbj|BAA00732.1| protein phosphatase type 1 alpha catalytic subunit [Rattus norvegicus] [NCBI NR]
  • gi|220865|dbj|BAA14194.1| protein phosphatase 1, catalytic subunit [Rattus norvegicus] [NCBI NR]
  • gi|1582003|prf||2117365A protein phosphatase 1:ISOTYPE=alpha [NCBI NR]
  • gi|149061962|gb|EDM12385.1| protein phosphatase 1, catalytic subunit, alpha isoform, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|13928710|ref|NP_113715.1| protein phosphatase 1, catalytic subunit, alpha [Rattus norvegicus] [NCBI NR]
  • pir||JX0157 phosphoprotein phosphatase (EC 3.1.3.16) 1-alpha catalytic chain [validated] - rat [NCBI NR]
  • Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Rattus norvegicus GN=Ppp1ca PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit [hmr_yeast5_DM3-1_pombe.fasta]
  • protein phosphatase 1, catalytic subunit, alpha; Protein phosphatase type 1 alpha, catalytic subunit; Protein phosphatase type 1 alpha catalytic subunit [HMR_022704-rand.fasta]
  • protein phosphatase 1, catalytic subunit, alpha isoform 1 [Homo sapiens]gi|13928710|ref|NP_113715.1| protein phosphatase 1, catalytic subunit, alpha [Rattus norvegicus]gi|30582097|gb|AAP35275.1| protein phosphatase 1, catalytic subunit, alpha isoform [H [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Serine/threonine protein phosphatase PP1-alpha catalytic subunit [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_031527) protein phosphatase type 1 alpha, catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 1, catalytic subunit, alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase type 1 alpha catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 1, catalytic subunit [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 1, catalytic subunit, alpha isoform, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Protein phosphatase 1, catalytic subunit, alpha isoform [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 1 alpha [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • protein phosphatase 1:ISOTYPE=alpha [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SERINE/THREONINE PROTEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • protein phosphatase type 1 alpha, catalytic subunit [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Ppp1ca Serine/threonine-protein phosphatase PP1-alpha catalytic subunit [rat-ipi-250309-contam.fasta]
  • Serine/threonine-protein phosphatase PP1-alpha catalytic subunit OS=Rattus norvegicus GN=Ppp1ca [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 330 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    protein phosphatase type 1 complex [IDA]
    cytoplasm [UNKNOWN][IDA]
    dendritic spine [IDA]
    cytosol [UNKNOWN]
    MLL5-L complex [UNKNOWN]
    neuronal cell body [IDA]
    nucleolus [IEA]
    glycogen granule [IDA]
    perikaryon [IDA]
    neuron projection [IDA]
    nucleoplasm [UNKNOWN][IEA]
    Biological Process: cell division [IEA]
    carbohydrate metabolic process [IEA]
    glycogen metabolic process [IEA]
    regulation of glycogen biosynthetic process [IDA]
    protein amino acid dephosphorylation [UNKNOWN][IDA]
    regulation of glycogen catabolic process [IDA]
    branching morphogenesis of a tube [UNKNOWN][IEA]
    cell cycle [IEA]
    lung development [UNKNOWN][IEA]
    Molecular Function: protein serine/threonine phosphatase activity [UNKNOWN]
    phosphoprotein phosphatase activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    ribonucleoprotein binding [IPI]
    protein phosphatase type 1 regulator activity [UNKNOWN]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSEKLNLD SIIGRLLEVQ GSRPGKNVQL TENEIRGLCL KSREIFLSQP ILLELEAPLK  60
   61 ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL 120
  121 LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL 180
  181 QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVQGWGEND RGVSFTFGAE VVAKFLHKHD 240
  241 LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAD 300
  301 KNKGKYGQFS GLNPGGRPIT PPRNSAKAKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..330] PSI-BLAST 126.0 Protein phosphatase-1 (PP-1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.126411744957937 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle