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Protein Overview: IL1B_RAT

General Information:
Name(s) found: IL1B_RAT [Swiss-Prot]
Description(s) found:
Found 15 descriptions.
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  • Interleukin-1 beta OS=Rattus norvegicus GN=Il1b PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 268 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    secretory granule [UNKNOWN][IEA]
    vesicle [UNKNOWN][IEA]
    extracellular region [IMP]
    Biological Process: positive regulation of JUN kinase activity [IMP]
    positive regulation of mitosis [UNKNOWN][IEA]
    positive regulation of transcription factor activity [UNKNOWN]
    memory [IMP]
    positive regulation of NF-kappaB transcription factor activity [UNKNOWN][IEA]
    positive regulation of angiogenesis [IEA]
    learning or memory [IEP]
    activation of MAPK activity [UNKNOWN][IEA]
    regulation of insulin secretion [UNKNOWN][IEA]
    inflammatory response [UNKNOWN][IEP]
    wound healing [IEP]
    immune response [IEA]
    anti-apoptosis [UNKNOWN][IEA]
    positive regulation of membrane protein ectodomain proteolysis [UNKNOWN][IEA]
    chronic inflammatory response to antigenic stimulus [IEP]
    negative regulation of adiponectin secretion [IEA]
    response to gamma radiation [IEP]
    negative regulation of lipid catabolic process [UNKNOWN][IEA]
    positive regulation vascular endothelial growth factor production [IEA]
    positive regulation of lipid catabolic process [IEA]
    response to ozone [IEP]
    response to chemical stimulus [UNKNOWN]
    positive regulation of calcidiol 1-monooxygenase activity [UNKNOWN][IEA]
    response to nutrient [IEP]
    positive regulation of interleukin-6 biosynthetic process [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    positive regulation of T cell proliferation [UNKNOWN][IEA]
    response to morphine [IEP]
    negative regulation of insulin receptor signaling pathway [IEA]
    negative regulation of glucose transport [IEA]
    response to estradiol stimulus [IEP]
    sequestering of triglyceride [UNKNOWN][IEA]
    positive regulation of interleukin-6 production [UNKNOWN][IDA]
    positive regulation of stress-activated MAPK cascade [IDA][IMP]
    positive regulation of nitric oxide biosynthetic process [UNKNOWN][IEA]
    response to vitamin D [IEP]
    negative regulation of MAP kinase activity [IEA]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IDA]
    regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN]
    response to heat [IEP]
    positive regulation of cell division [IEA]
    angiogenesis [IMP]
    cytokine-mediated signaling pathway [UNKNOWN][IEP]
    ovulation [IEP]
    response to glucocorticoid stimulus [IEP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    response to L-ascorbic acid [IEP]
    social behavior [IMP]
    response to ATP [UNKNOWN][IEA]
    negative regulation of glutamate secretion [IMP]
    aging [IMP]
    fever [IEA][IEP]
    elevation of cytosolic calcium ion concentration [IDA]
    positive regulation of interleukin-2 biosynthetic process [UNKNOWN][IEA]
    response to drug [IEP]
    positive regulation of JNK cascade [UNKNOWN][IDA]
    positive regulation of protein amino acid phosphorylation [UNKNOWN]
    positive regulation of apoptosis [IMP]
    positive regulation of ERK1 and ERK2 cascade [IDA]
    neutrophil chemotaxis [UNKNOWN][IEA]
    response to lipopolysaccharide [UNKNOWN][IEP]
    leukocyte migration [UNKNOWN][IEA]
    response to organic nitrogen [IEP]
    positive regulation of chemokine biosynthetic process [UNKNOWN][IEA]
    Molecular Function: growth factor activity [IEA]
    protein domain specific binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    cytokine activity [UNKNOWN][TAS]
    interleukin-1 receptor binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATVPELNCE IAAFDSEEND LFFEADRPQK IKDCFQALDL GCPDESIQLQ ISQQHLDKSF  60
   61 RKAVSLIVAV EKLWQLPMSC PWSFQDEDPS TFFSFIFEEE PVLCDSWDDD DLLVCDVPIR 120
  121 QLHCRLRDEQ QKCLVLSDPC ELKALHLNGQ NISQQVVFSM SFVQGETSND KIPVALGLKG 180
  181 LNLYLSCVMK DGTPTLQLES VDPKQYPKKK MEKRFVFNKI EVKTKVEFES AQFPNWYIST 240
  241 SQAEHRPVFL GNSNGRDIVD FTMEPVSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle