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Protein Overview: gi|18461161, gi|...

General Information:
Name(s) found: gi|18959220 [NCBI NR]
gi|18461161 [NCBI NR]
gi|149040278 [NCBI NR]
Description(s) found:
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  • gi|18959220|ref|NP_579820.1| fibroblast growth factor 8 [Rattus norvegicus] [NCBI NR]
  • gi|18461161|dbj|BAB84359.1| FGF8 [Rattus norvegicus] [NCBI NR]
  • gi|149040278|gb|EDL94316.1| fibroblast growth factor 8, isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • Ensembl_locations(Chr-bp):1-252949211 fibroblast growth factor 8 [hmr_yeast5_DM3-1_pombe.fasta]
  • fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced) [HMR_022704-rand.fasta]
  • fibroblast growth factor 8 [Rattus norvegicus]gi|15147350|ref|NP_149355.1| fibroblast growth factor 8 isoform A precursor [Homo sapiens]gi|1399444|gb|AAC50783.1| fibroblast growth factor 8 precursorgi|732821|emb|CAA88637.1| fibroblast growth factor 8 [ [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 FGF8 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_133286) fibroblast growth factor 8; fibroblast growth factor 8 (androgen-induced) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • fibroblast growth factor 8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • fibroblast growth factor 8, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • FGF8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Fgf8 Fibroblast growth factor 8, isoform CRA_b [rat-ipi-250309-contam.fasta]
  • FGF8 OS=Rattus norvegicus GN=Fgf8 [011711_HMR.fasta]
  • Fibroblast growth factor OS=Rattus norvegicus GN=Fgf8 PE=2 SV=1 [20141208_RAT.fasta]
  • FGF8 OS=Rattus norvegicus GN=Fgf8 PE=2 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 204 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN]
    soluble fraction [UNKNOWN]
    external side of plasma membrane [IDA]
    extracellular region [UNKNOWN]
    Biological Process: neuroepithelial cell differentiation [UNKNOWN]
    embryonic development ending in birth or egg hatching [UNKNOWN]
    cell migration involved in mesendoderm migration [UNKNOWN]
    fibroblast growth factor receptor signaling pathway [UNKNOWN]
    forebrain dorsal/ventral pattern formation [UNKNOWN]
    central nervous system neuron development [IMP]
    positive regulation of mitosis [UNKNOWN]
    branching involved in salivary gland morphogenesis [UNKNOWN]
    heart morphogenesis [UNKNOWN]
    kidney development [UNKNOWN]
    mesonephros development [UNKNOWN]
    apoptosis [UNKNOWN]
    heart looping [UNKNOWN]
    embryonic hindlimb morphogenesis [UNKNOWN]
    mesodermal cell migration [UNKNOWN]
    subpallium development [UNKNOWN]
    response to organic cyclic substance [IEP]
    pallium development [UNKNOWN]
    male genitalia development [UNKNOWN]
    positive regulation of gene expression [UNKNOWN]
    inner ear morphogenesis [UNKNOWN]
    induction of an organ [UNKNOWN]
    limb morphogenesis [UNKNOWN]
    neural plate morphogenesis [UNKNOWN]
    dorsal/ventral axon guidance [IMP]
    motor axon guidance [IMP]
    telencephalon development [UNKNOWN]
    positive regulation of cell proliferation [UNKNOWN]
    odontogenesis [UNKNOWN][IEP]
    generation of neurons [UNKNOWN]
    forebrain morphogenesis [UNKNOWN]
    negative regulation of neuron apoptosis [UNKNOWN]
    bone development [UNKNOWN]
    lung morphogenesis [UNKNOWN]
    MAPKKK cascade [UNKNOWN]
    response to oxidative stress [IDA]
    heart development [UNKNOWN]
    patterning of blood vessels [UNKNOWN]
    lung development [UNKNOWN]
    cell proliferation in forebrain [UNKNOWN]
    embryonic heart tube development [UNKNOWN]
    regulation of odontogenesis of dentine-containing tooth [UNKNOWN]
    determination of left/right symmetry [UNKNOWN]
    forebrain neuron development [IMP]
    blood vessel remodeling [UNKNOWN]
    gonad development [UNKNOWN]
    metanephros development [UNKNOWN]
    dopaminergic neuron differentiation [UNKNOWN]
    branching involved in ureteric bud morphogenesis [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    cell fate commitment [UNKNOWN]
    Molecular Function: growth factor activity [UNKNOWN][IEA]
    chemoattractant activity [IMP]
    type 2 fibroblast growth factor receptor binding [UNKNOWN]
    type 1 fibroblast growth factor receptor binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK  60
   61 RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 120
  121 IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF 180
  181 EFLNYPPFTR SLRGSQRTWA PEPR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 52.0 Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • growth factor activity
    		•  5.6790632853895 bayes_pls_golite062009
  • fibroblast growth factor receptor binding
    		•  5.32138222782692 bayes_pls_golite062009
  • receptor binding
    		•  4.8109037277027 bayes_pls_golite062009
  • cytokine activity
    		•  3.23273280319483 bayes_pls_golite062009
  • protein binding
    		•  2.99442649109752 bayes_pls_golite062009
  • binding
    		•  2.26121569090272 bayes_pls_golite062009
  • heparin binding
    		•  2.1616134585534 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.0664969520492 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.81686028727894 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.16870777190189 bayes_pls_golite062009
  • signal transducer activity
    		•  1.16870777190189 bayes_pls_golite062009
  • transporter activity
    		•  0.901374747438933 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  0.8084616632765 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.718170110067115 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.507427648555795 bayes_pls_golite062009
  • pattern binding
    		•  0.323275442862789 bayes_pls_golite062009
  • nerve growth factor receptor binding
    		•  0.308245352535379 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.280573521182099 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.146644241088165 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0138670393997913 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle