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View Structure Prediction Details

Protein: gi|18461161, gi|...
Organism: Rattus norvegicus
Length: 204 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|18461161, gi|....

Description E-value Query
Range
Subject
Range
gi|1773016 - gi|1773016|emb|CAA71365.1| fibroblast growth factor 8 [Xenopus laevis]
3.0E-62 [1..195] [1..195]
gi|76654957 - gi|76654957|ref|XP_612205.2| PREDICTED: fibroblast growth factor 8 (androgen-induced) [Bos taurus]
4.0E-61 [2..204] [193..397]
FGF8_CHICK - Fibroblast growth factor 8 OS=Gallus gallus GN=FGF8 PE=2 SV=1
2.0E-60 [1..203] [1..214]
gi|73998728 - gi|73998728|ref|XP_851783.1| PREDICTED: similar to fibroblast growth factor 8 isoform E precursor [C...
4.0E-60 [2..204] [83..287]
gi|220325, gi|74... - gi|74203535|dbj|BAE20919.1| unnamed protein product [Mus musculus], pir||A46245 fibroblast growth fa...
gi|1143271, gi|5... - gi|999172|gb|AAB34255.1| androgen-induced growth factor AIGF [Homo sapiens], gi|7512433|pir||G02092 ...
9.0E-60 [22..204] [33..215]
gi|28913543 - gi|28913543|gb|AAH48734.1| Fgf8 protein [Mus musculus]
9.0E-60 [22..204] [62..244]
gi|51949976, gi|... - gi|56118518|ref|NP_001008163.1| fibroblast growth factor 8 (androgen-induced) [Xenopus (Silurana) tr...
1.0E-59 [1..195] [1..206]

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Predicted Domain #1
Region A:
Residues: [1-204]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSPRSALSC LLLHLLVLCL QAQHVREQSL VTDQLSRRLI RTYQLYSRTS GKHVQVLANK  60
   61 RINAMAEDGD PFAKLIVETD TFGSRVRVRG AETGLYICMN KKGKLIAKSN GKGKDCVFTE 120
  121 IVLENNYTAL QNAKYEGWYM AFTRKGRPRK GSKTRQHQRE VHFMKRLPRG HHTTEQSLRF 180
  181 EFLNYPPFTR SLRGSQRTWA PEPR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 52.0
Match: 2fdbM
Description: Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 5.6790632853895 bayes_pls_golite062009
fibroblast growth factor receptor binding 5.32138222782692 bayes_pls_golite062009
receptor binding 4.8109037277027 bayes_pls_golite062009
cytokine activity 3.23273280319483 bayes_pls_golite062009
protein binding 2.99442649109752 bayes_pls_golite062009
binding 2.26121569090272 bayes_pls_golite062009
heparin binding 2.1616134585534 bayes_pls_golite062009
glycosaminoglycan binding 2.0664969520492 bayes_pls_golite062009
polysaccharide binding 1.81686028727894 bayes_pls_golite062009
molecular transducer activity 1.16870777190189 bayes_pls_golite062009
signal transducer activity 1.16870777190189 bayes_pls_golite062009
transporter activity 0.901374747438933 bayes_pls_golite062009
interleukin-1 receptor binding 0.8084616632765 bayes_pls_golite062009
transmembrane transporter activity 0.718170110067115 bayes_pls_golite062009
substrate-specific transporter activity 0.507427648555795 bayes_pls_golite062009
pattern binding 0.323275442862789 bayes_pls_golite062009
nerve growth factor receptor binding 0.308245352535379 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.280573521182099 bayes_pls_golite062009
receptor signaling protein activity 0.146644241088165 bayes_pls_golite062009
ion transmembrane transporter activity 0.0138670393997913 bayes_pls_golite062009

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