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Protein Overview: SHIP2_RAT

General Information:
Name(s) found: SHIP2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|81869928|sp|Q9WVR3.1|SHIP2_RAT RecName: Full=Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; AltName: Full=SH2 domain-containing inositol-5'-phosphatase 2; Short=SHIP-2; AltName: Full=Inositol polyphosphate phosphatase-like protein 1; Short=I [NCBI NR]
  • gi|5381251|dbj|BAA82308.1| SH2-containing inositol phosphatase 2 (SHIP2) [Rattus norvegicus] [NCBI NR]
  • gi|12621112|ref|NP_075233.1| inositol polyphosphate phosphatase-like 1 [Rattus norvegicus] [NCBI NR]
  • Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Rattus norvegicus GN=Inppl1 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-156772520 SH2-containing inositol phosphatase 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • SH2-containing inositol phosphatase 2 [HMR_022704-rand.fasta]
  • SH2-containing inositol phosphatase 2 [Rattus norvegicus]gi|5381251|dbj|BAA82308.1| SH2-containing inositol phosphatase 2 (SHIP2) [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 SH2-containing inositol phosphatase 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_022944) SH2-containing inositol phosphatase 2 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (SH2 domain-containing inositol-5'-phosphatase 2) (SHIP-2) (Inositol polyphosphate phosphatase-like protein 1) (INPPL-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • inositol polyphosphate phosphatase-like 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • SH2-containing inositol phosphatase 2 (SHIP2) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SH2-CONTAINING INOSITOL PHOSPHATASE 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • SH2-containing inositol phosphatase 2 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Inppl1 Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 [rat-ipi-250309-contam.fasta]
  • Isoform 1 of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 OS=Rattus norvegicus GN=Inppl1 [011711_HMR.fasta]
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 OS=Rattus norvegicus GN=Inppl1 PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1257 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    cytoplasm [UNKNOWN][IEA]
    cytosol [IEA]
    plasma membrane [UNKNOWN][IEA]
    actin cortical patch [IEA]
    lamellipodium [IDA]
    Biological Process: negative regulation of MAP kinase activity [IMP]
    negative regulation of cell proliferation [UNKNOWN][IEA]
    post-embryonic development [UNKNOWN][IEA]
    cellular lipid metabolic process [UNKNOWN][IEA]
    cell adhesion [IEA]
    brain development [IEP]
    negative regulation of DNA replication [IMP]
    glucose metabolic process [UNKNOWN][IEA]
    negative regulation of insulin receptor signaling pathway [IMP]
    negative regulation of insulin-like growth factor receptor signaling pathway [IMP]
    inositol trisphosphate metabolic process [IDA]
    negative regulation of gene expression [UNKNOWN][IEA]
    response to insulin stimulus [UNKNOWN][IEA]
    negative regulation of neuron projection development [IMP]
    response to drug [IEP]
    negative regulation of platelet-derived growth factor receptor signaling pathway [IMP]
    Molecular Function: phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
    inositol or phosphatidylinositol phosphatase activity [IEA]
    protein binding [UNKNOWN][IDA]
    actin binding [IEA]
    SH3 domain binding [IEA]
    SH2 domain binding [UNKNOWN]
    inositol-polyphosphate 5-phosphatase activity [IDA][TAS]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASVCGAPSP GGALGSQAPA WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV  60
   61 LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE 120
  121 REPDPPDDRD ASDVEDEKPP LPPRSGSTSI SVPAGPSSPL PAPETPTTPA AESTPNGLST 180
  181 VSHEYLKGSY GLDLEAVRGG ASNLPHLTRT LVTSCRRLHS EVDKVLSGLE ILSKVFDQQS 240
  241 SPMVTRLLQQ QSLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPLQP 300
  301 SIRKAKTIPV QAFEVKLDVT LGDLTKIGKS QKFTLSVDVE GGRLVLLRRQ RDSQEDWTTF 360
  361 THDRIRQLIK SQRVQNKLGV VFEKEKDRTQ RKDFIFVSAR KREAFCQLLQ LMKNKHSKQD 420
  421 EPDMISVFIG TWNMGSVPPP KNVTSWFTSK GLGKALDEVT VTIPHDIYVF GTQENSVGDR 480
  481 EWLDLLRGGL KELTDLDYRP IAMQSLWNIK VAVLVKPEHE NRISHVSTSS VKTGIANTLG 540
  541 NKGAVGVSFM FNGTSFGFVN CHLTSGNEKT TRRNQNYLDI LRLLSLGDRQ LSAFDISLRF 600
  601 THLFWFGDLN YRLDMDIQEI LNYISRREFE PLLRVDQLNL EREKHKVFLR FSEEEISFPP 660
  661 TYRYERGSRD TYAWHKQKPT GVRTNVPSWC DRILWKSYPE THIICNSYGC TDDIVTSDHS 720
  721 PVFGTFEVGV TSQFISKKGL SKTSDQAYIE FESIEAIVKT ASRTKFFIEF YSTCLEEYKK 780
  781 SFENDAQSSD NINFLKVQWS SRQLPTLKPI LADIEYLQDQ HLLLTVKSMD GYESYGECVV 840
  841 ALKSMIGSTA QQFLTFLSHR GEETGNIRGS MKVRVPTERL GTRERLYEWI SIDKDDTGAK 900
  901 SKAPSVLRGS QEHRSGSRKP TSTEASCPLS KLFEEPEKPP PTGRPPAPPR AVPREESLNP 960
  961 RLKSEGTPEQ EGVAAPPPKN SFNNPAYYVL EGVPHQLLPL EPTSFARAPI PPTTKNKVAI1020
 1021 TVPAPQLGRH RTPRVGEGSS SDEDSGGTLP PPDFPPPPLP DSAIFLPPNL DPLSMPVVRG1080
 1081 RSVGEARGPP PPKAHPRPPL PPGTSPASTF LEEVASADDR SCSVLQMAKT LSEVDYSPGP1140
 1141 GRSALLPNPL ELQLPRGPSD YGRPLSFPPP RIRESIQEDL AEEAPCPQGG RASGLGEAGM1200
 1201 GAWLRAIGLE RYEEGLVHNG WDDLEFLSDI TEEDLEEAGV QDPAHKRLLL DTLQLSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle