Protein Overview: GRB2_RAT

General Information:
Name(s) found:	GRB2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|77539774\|ref\|NP_110473.2\| growth factor receptor bound protein 2 [Rattus norvegicus] [NCBI NR] gi\|60552087\|gb\|AAH91144.1\| Growth factor receptor bound protein 2 [Rattus norvegicus] [NCBI NR] gi\|55763\|emb\|CAA44665.1\| ash protein [Rattus norvegicus] [NCBI NR] gi\|51702260\|sp\|P62994.1\|GRB2_RAT RecName: Full=Growth factor receptor-bound protein 2; AltName: Full=Adapter protein GRB2; AltName: Full=SH2/SH3 adapter GRB2; AltName: Full=Protein Ash [NCBI NR] pir\|\|S26050 growth factor receptor-bound protein, GRB2 - rat [NCBI NR] gi\|149054788\|gb\|EDM06605.1\| growth factor receptor bound protein 2, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149054787\|gb\|EDM06604.1\| growth factor receptor bound protein 2, isoform CRA_a [Rattus norvegicus] [NCBI NR] Growth factor receptor-bound protein 2 OS=Rattus norvegicus GN=Grb2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Splice isoform 1 of P29354 [hmr_yeast5_DM3-1_pombe.fasta] growth factor receptor-bound protein 2 isoform 1 [Homo sapiens]gi\|12653693\|gb\|AAH00631.1\| Growth factor receptor-bound protein 2, isoform 1 [Homo sapiens]gi\|55763\|emb\|CAA44665.1\| ash protein [Rattus norvegicus]gi\|20379026\|gb\|AAM21073.1\| growth factor r [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of Growth factor receptor-bound protein 2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] growth factor receptor bound protein 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] growth factor receptor bound protein 2, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ash protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Growth factor receptor bound protein 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Grb2 Isoform 1 of Growth factor receptor-bound protein 2 [rat-ipi-250309-contam.fasta] growth factor receptor-bound protein 2 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Isoform 1 of Growth factor receptor-bound protein 2 OS=Rattus norvegicus GN=Grb2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	217 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [UNKNOWN][IEA] vesicle membrane [UNKNOWN][IEA] membrane [UNKNOWN][IEA] cytosol [UNKNOWN] Golgi apparatus [IEA] protein complex [IDA]
Biological Process:	regulation of MAPKKK cascade [UNKNOWN][IEA] insulin receptor signaling pathway [UNKNOWN][IEA] branching involved in embryonic placenta morphogenesis [UNKNOWN][IEA] cell differentiation [UNKNOWN][IEA] fibroblast growth factor receptor signaling pathway [UNKNOWN][IEA] anatomical structure formation involved in morphogenesis [UNKNOWN][IEA] Ras protein signal transduction [UNKNOWN][TAS] protein heterooligomerization [IDA] aging [IPI] receptor internalization [UNKNOWN]
Molecular Function:	phosphotyrosine binding [IPI] protein domain specific binding [UNKNOWN][IPI] SH3/SH2 adaptor activity [UNKNOWN][IEA] protein binding [UNKNOWN] insulin receptor substrate binding [UNKNOWN][IPI] epidermal growth factor receptor binding [UNKNOWN][ISS] phosphoprotein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW  60
   61 FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120
  121 WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG 180
  181 DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
molecular transducer activity	3.13508395312263	bayes_pls_golite062009
signal transducer activity	3.13508395312263	bayes_pls_golite062009
epidermal growth factor receptor binding	2.9751846707539	bayes_pls_golite062009
binding	2.69791297400248	bayes_pls_golite062009
cytoskeletal protein binding	2.57554390739461	bayes_pls_golite062009
actin binding	2.17709619225063	bayes_pls_golite062009
protein binding	2.14586566310919	bayes_pls_golite062009
insulin receptor binding	2.1238568876176	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.85015570449703	bayes_pls_golite062009
molecular adaptor activity	1.81145713371725	bayes_pls_golite062009
receptor binding	1.80554013976158	bayes_pls_golite062009
kinase activity	1.78069536883109	bayes_pls_golite062009
protein kinase activity	1.64363774024605	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.59739467025045	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.59474164216385	bayes_pls_golite062009
transferase activity	1.19152443245584	bayes_pls_golite062009
actin filament binding	1.03574214978228	bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity	1.03150090191995	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.950445630788802	bayes_pls_golite062009
transporter activity	0.896907103596953	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
transcription regulator activity	0.786324379459923	bayes_pls_golite062009
transmembrane transporter activity	0.713068405985864	bayes_pls_golite062009
nucleic acid binding	0.696368655705791	bayes_pls_golite062009
protein complex binding	0.65988681496356	bayes_pls_golite062009
protein phosphorylated amino acid binding	0.649814096718101	bayes_pls_golite062009
DNA binding	0.578730664467311	bayes_pls_golite062009
enzyme regulator activity	0.456661966897198	bayes_pls_golite062009
sevenless binding	0.418968910155118	bayes_pls_golite062009
phosphotyrosine binding	0.311079584914389	bayes_pls_golite062009
insulin receptor substrate binding	0.29798436765753	bayes_pls_golite062009
substrate-specific transporter activity	0.245869952317152	bayes_pls_golite062009
structural molecule activity	0.236653863910566	bayes_pls_golite062009
protein tyrosine kinase activity	0.206747304356052	bayes_pls_golite062009
phosphoprotein binding	0.16798254471727	bayes_pls_golite062009
kinase binding	0.131981353175621	bayes_pls_golite062009
receptor signaling protein activity	0.0443241110585009	bayes_pls_golite062009
transcription factor activity	0.0291114923524518	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.0273219613963591	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..217]	PSI-BLAST	42.09691	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains; Growth factor receptor-bound protein 2 (GRB2)

Protein Overview: GRB2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: