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Protein Overview: NMDE2_RAT

General Information:
Name(s) found: NMDE2_RAT [Swiss-Prot]
Description(s) found:
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  • gi|548372|sp|Q00960.1|NMDE2_RAT RecName: Full=Glutamate [NMDA] receptor subunit epsilon-2; AltName: Full=N-methyl D-aspartate receptor subtype 2B; Short=NMDAR2B; Short=NR2B; Flags: Precursor [NCBI NR]
  • pir||B43274 N-methyl-D-aspartate receptor 2B - rat [NCBI NR]
  • gi|205739|gb|AAA41714.1| NMDA receptor subtype 2B [NCBI NR]
  • (Q00960) Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) [Swiss-Prot]
  • Glutamate receptor ionotropic, NMDA 2B OS=Rattus norvegicus GN=Grin2b PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):4-178921721 Glutamate [NMDA] receptor subunit epsilon 2 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • N-methyl-D-aspartate receptor 2B - ratgi|548372|sp|Q00960|NME2_RAT Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B)gi|205739|gb|AAA41714.1| NMDA receptor subtype 2B [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Glutamate [NMDA] receptor subunit epsilon 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Glutamate [NMDA] receptor subunit epsilon-2 precursor (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • unnamed protein product [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • NMDA receptor subtype 2B [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Glutamate [NMDA] receptor subunit epsilon 2 precursor (N-methyl D-aspartate receptor subtype 2B) (NR2B) (NMDAR2B) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Grin2b Glutamate [NMDA] receptor subunit epsilon-2 [rat-ipi-250309-contam.fasta]
  • Glutamate [NMDA] receptor subunit epsilon-2 OS=Rattus norvegicus GN=Grin2b [011711_HMR.fasta]
  • Glutamate [NMDA] receptor subunit epsilon-2 OS=Rattus norvegicus GN=Grin2b PE=1 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1482 amino acids

    Gene Ontology:
    Cellular Component: presynaptic membrane [IDA]
    postsynaptic density [UNKNOWN][IDA]
    synaptosome [UNKNOWN][IEA]
    synaptic vesicle [UNKNOWN][IEA]
    synapse [UNKNOWN][IDA][TAS]
    neuron projection [IDA]
    plasma membrane [UNKNOWN][IEA]
    membrane fraction [UNKNOWN]
    Z disc [IDA]
    synaptic cleft [IDA]
    postsynaptic membrane [UNKNOWN][IEA]
    dendritic spine [IDA]
    integral to membrane [IEA]
    cell junction [IEA]
    outer membrane-bounded periplasmic space [IEA]
    N-methyl-D-aspartate selective glutamate receptor complex [UNKNOWN][IDA]
    Biological Process: embryonic development [UNKNOWN][IEA]
    regulation of MAPKKK cascade [IMP]
    fear response [UNKNOWN]
    learning [UNKNOWN]
    associative learning [IMP]
    memory [UNKNOWN][IDA]
    learning or memory [TAS]
    response to ethanol [UNKNOWN][IEA]
    cation transport [UNKNOWN][IEA]
    startle response [UNKNOWN][IEA]
    in utero embryonic development [UNKNOWN][IEA]
    regulation of long-term neuronal synaptic plasticity [IMP]
    suckling behavior [UNKNOWN][IEA]
    calcium ion transport [UNKNOWN][IEA]
    regulation of synaptic plasticity [UNKNOWN]
    behavioral response to pain [UNKNOWN][IEA]
    regulation of action potential [IMP]
    ionotropic glutamate receptor signaling pathway [IDA]
    regulation of postsynaptic membrane potential [UNKNOWN]
    regulation of excitatory postsynaptic membrane potential [UNKNOWN][IEA]
    synaptic transmission [UNKNOWN]
    sensory organ development [UNKNOWN][IEA]
    behavioral fear response [UNKNOWN][IEA]
    rhythmic process [IDA]
    detection of mechanical stimulus involved in sensory perception of pain [UNKNOWN][IEA]
    positive regulation of glutamate secretion [IDA]
    Molecular Function: zinc ion binding [IDA]
    calcium channel activity [UNKNOWN][IEA]
    cation channel activity [UNKNOWN]
    cell adhesion molecule binding [IPI]
    neurotransmitter binding [IDA]
    receptor activity [IEA]
    ionotropic glutamate receptor activity [IDA]
    receptor binding [IPI]
    extracellular-glutamate-gated ion channel activity [IDA]
    transporter activity [IEA]
    N-methyl-D-aspartate selective glutamate receptor activity [UNKNOWN][IDA]
    ion channel activity [IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    protein heterodimerization activity [IDA]
    D2 dopamine receptor binding [IPI]
    glycine binding [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPSAECCSP KFWLVLAVLA VSGSKARSQK SPPSIGIAVI LVGTSDEVAI KDAHEKDDFH  60
   61 HLSVVPRVEL VAMNETDPKS IITRICDLMS DRKIQGVVFA DDTDQEAIAQ ILDFISAQTL 120
  121 TPILGIHGGS SMIMADKDES SMFFQFGPSI EQQASVMLNI MEEYDWYIFS IVTTYFPGYQ 180
  181 DFVNKIRSTI ENSFVGWELE EVLLLDMSLD DGDSKIQNQL KKLQSPIILL YCTKEEATYI 240
  241 FEVANSVGLT GYGYTWIVPS LVAGDTDTVP SEFPTGLISV SYDEWDYGLP ARVRDGIAII 300
  301 TTAASDMLSE HSFIPEPKSS CYNTHEKRIY QSNMLNRYLI NVTFEGRNLS FSEDGYQMHP 360
  361 KLVIILLNKE RKWERVGKWK DKSLQMKYYV WPRMCPETEE QEDDHLSIVT LEEAPFVIVE 420
  421 SVDPLSGTCM RNTVPCQKRI ISENKTDEEP GYIKKCCKGF CIDILKKISK SVKFTYDLYL 480
  481 VTNGKHGKKI NGTWNGMIGE VVMKRAYMAV GSLTINEERS EVVDFSVPFI ETGISVMVSR 540
  541 SNGTVSPSAF LEPFSADVWV MMFVMLLIVS AVAVFVFEYF SPVGYNRCLA DGREPGGPSF 600
  601 TIGKAIWLLW GLVFNNSVPV QNPKGTTSKI MVSVWAFFAV IFLASYTANL AAFMIQEEYV 660
  661 DQVSGLSDKK FQRPNDFSPP FRFGTVPNGS TERNIRNNYA EMHAYMGKFN QRGVDDALLS 720
  721 LKTGKLDAFI YDAAVLNYMA GRDEGCKLVT IGSGKVFAST GYGIAIQKDS GWKRQVDLAI 780
  781 LQLFGDGEME ELEALWLTGI CHNEKNEVMS SQLDIDNMAG VFYMLGAAMA LSLITFICEH 840
  841 LFYWQFRHCF MGVCSGKPGM VFSISRGIYS CIHGVAIEER QSVMNSPTAT MNNTHSNILR 900
  901 LLRTAKNMAN LSGVNGSPQS ALDFIRRESS VYDISEHRRS FTHSDCKSYN NPPCEENLFS 960
  961 DYISEVERTF GNLQLKDSNV YQDHYHHHHR PHSIGSTSSI DGLYDCDNPP FTTQPRSISK1020
 1021 KPLDIGLPSS KHSQLSDLYG KFSFKSDRYS GHDDLIRSDV SDISTHTVTY GNIEGNAAKR1080
 1081 RKQQYKDSLK KRPASAKSRR EFDEIELAYR RRPPRSPDHK RYFRDKEGLR DFYLDQFRTK1140
 1141 ENSPHWEHVD LTDIYKERSD DFKRDSVSGG GPCTNRSHLK HGTGEKHGVV GGVPAPWEKN1200
 1201 LTNVDWEDRS GGNFCRSCPS KLHNYSSTVA GQNSGRQACI RCEACKKAGN LYDISEDNSL1260
 1261 QELDQPAAPV AVTSNASSTK YPQSPTNSKA QKKNRNKLRR QHSYDTFVDL QKEEAALAPR1320
 1321 SVSLKDKGRF MDGSPYAHMF EMPAGESSFA NKSSVPTAGH HHNNPGSGYM LSKSLYPDRV1380
 1381 TQNPFIPTFG DDQCLLHGSK SYFFRQPTVA GASKTRPDFR ALVTNKPVVV TLHGAVPGRF1440
 1441 QKDICIGNQS NPCVPNNKNP RAFNGSSNGH VYEKLSSIES DV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle