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Protein Overview: IL6_RAT

General Information:
Name(s) found: IL6_RAT [Swiss-Prot]
Description(s) found:
Found 20 descriptions.
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  • Interleukin-6 OS=Rattus norvegicus GN=Il6 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 211 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    external side of plasma membrane [UNKNOWN][IEA]
    extracellular region [IEA]
    interleukin-6 receptor complex [UNKNOWN]
    Biological Process: positive regulation of translation [UNKNOWN]
    response to peptidoglycan [UNKNOWN]
    negative regulation of gluconeogenesis [IDA]
    negative regulation of muscle organ development [IDA]
    positive regulation of anti-apoptosis [UNKNOWN]
    positive regulation of transcription factor activity [UNKNOWN]
    [NOT]positive regulation of NF-kappaB transcription factor activity [UNKNOWN]
    branching involved in salivary gland morphogenesis [UNKNOWN][IEA]
    glucagon secretion [IEA]
    positive regulation of acute inflammatory response [UNKNOWN]
    inflammatory response [UNKNOWN]
    negative regulation of collagen biosynthetic process [UNKNOWN]
    immune response [IEA]
    positive regulation of gene-specific transcription [UNKNOWN]
    positive regulation of B cell activation [UNKNOWN]
    positive regulation of transcription, DNA-dependent [UNKNOWN][IEA]
    negative regulation of caspase activity [IDA]
    defense response to virus [UNKNOWN]
    regulation of vascular endothelial growth factor production [UNKNOWN]
    positive regulation of chemokine production [UNKNOWN]
    response to electrical stimulus [IEP]
    positive regulation of epithelial cell proliferation [UNKNOWN][IEA]
    defense response to Gram-positive bacterium [UNKNOWN]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN]
    negative regulation of cytokine secretion [IDA]
    regulation of apoptosis [UNKNOWN][IEA]
    cell redox homeostasis [IMP]
    response to organic cyclic substance [IEP]
    positive regulation of T cell proliferation [UNKNOWN]
    positive regulation of JAK-STAT cascade [UNKNOWN][IDA]
    positive regulation of transmission of nerve impulse [IDA]
    regulation of circadian sleep/wake cycle, non-REM sleep [IMP]
    response to yeast [IEP]
    positive regulation of gene expression [IDA]
    positive regulation of interleukin-6 production [UNKNOWN]
    response to nutrient levels [IEP]
    regulation of cell shape [IDA]
    response to cytokine stimulus [IEP]
    neuroprotection [IDA]
    positive regulation of protein import into nucleus, translocation [IDA]
    positive regulation of nitric oxide biosynthetic process [IDA]
    muscle cell homeostasis [UNKNOWN][IEA]
    positive regulation of tyrosine phosphorylation of Stat3 protein [UNKNOWN]
    negative regulation of cell proliferation [IMP]
    positive regulation of cell proliferation [UNKNOWN]
    response to wounding [IEP]
    response to amino acid stimulus [IEP]
    response to antibiotic [IEP]
    positive regulation of neuron differentiation [IMP]
    positive regulation of DNA replication [IMP]
    hepatic immune response [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    epithelial cell proliferation involved in salivary gland morphogenesis [UNKNOWN][IEA]
    negative regulation of protein kinase activity [IDA]
    response to mechanical stimulus [IEP]
    defense response to protozoan [UNKNOWN][IEA]
    positive regulation of smooth muscle cell proliferation [UNKNOWN]
    response to cold [IEP]
    response to heat [IEP]
    positive regulation of immunoglobulin secretion [UNKNOWN]
    response to insulin stimulus [IEP]
    negative regulation of chemokine biosynthetic process [UNKNOWN][IEA]
    cytokine-mediated signaling pathway [UNKNOWN]
    response to glucocorticoid stimulus [UNKNOWN]
    interleukin-6-mediated signaling pathway [UNKNOWN][IEA]
    response to protein stimulus [IEP]
    endocrine pancreas development [IEA]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    bone remodeling [IEP]
    defense response to Gram-negative bacterium [UNKNOWN]
    neuron projection development [UNKNOWN]
    positive regulation of T-helper 2 cell differentiation [UNKNOWN][IEA]
    positive regulation of MAPKKK cascade [UNKNOWN]
    aging [IEP]
    neutrophil apoptosis [UNKNOWN][IEA]
    acute-phase response [IEA]
    regulation of cell proliferation [UNKNOWN]
    negative regulation of hormone secretion [UNKNOWN][IEA]
    response to bacterium [IEP]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    response to calcium ion [IEP]
    positive regulation of ERK1 and ERK2 cascade [IDA]
    response to caffeine [IEP]
    response to lipopolysaccharide [IEP]
    Molecular Function: growth factor activity [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    cytokine activity [UNKNOWN][IDA]
    receptor binding [IDA]
    interleukin-6 receptor binding [UNKNOWN][IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ VGGLITYVLR  60
   61 EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF QTGYNQEICL LKICSGLLEF 120
  121 RFYLEFVKNN LQDNKKDKAR VIQSNTETLV HIFKQEIKDS YKIVLPTPTS NALLMEKLES 180
  181 QKEWLRTKTI QLILKALEEF LKVTMRSTRQ T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle