Protein Overview: CAC1C_RAT

General Information:
Name(s) found:	CAC1C_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|29789032\|ref\|NP_036649.1\| calcium channel, voltage-dependent, L type, alpha 1C subunit [Rattus norvegicus] [NCBI NR] gi\|207647\|gb\|AAA85463.1\| dihydropryridine-sensitive calcium channel alpha-1 subunit [NCBI NR] gi\|116412\|sp\|P22002.1\|CAC1C_RAT RecName: Full=Voltage-dependent L-type calcium channel subunit alpha-1C; AltName: Full=Voltage-gated calcium channel subunit alpha Cav1.2; AltName: Full=Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscl [NCBI NR] (P22002) Voltage-dependent L-type calcium channel alpha-1C subunit (Voltage-gated calcium channel alpha subunit Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (RAT brain class C) (RBC) [Swiss-Prot] Voltage-dependent L-type calcium channel subunit alpha-1C OS=Rattus norvegicus GN=Cacna1c PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-160621050 Splice isoform 2 of P22002 [hmr_yeast5_DM3-1_pombe.fasta] calcium channel, voltage-dependent, alpha 1C subunit; Ca channel, voltage-dependent, L type, alpha 1c subunit; RATIVS302; Ca channel voltage-dependent L type alpha 1c subunit [HMR_022704-rand.fasta] calcium channel, voltage-dependent, L type, alpha 1C subunit [Rattus norvegicus]gi\|116412\|sp\|P22002\|CCAC_RAT Voltage-dependent L-type calcium channel alpha-1C subunit (Voltage-gated calcium channel alpha subunit Cav1.2) (Calcium channel, L type, alpha-1 [nrdb_11152004_Chlamydomonas] Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage-gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] dihydropryridine-sensitive calcium channel alpha-1 subunit [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] calcium channel, voltage-dependent, L type, alpha 1C subunit [Rattus norvegicus] [nr-271106-contam.fasta] Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage-gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (RAT brain class C) (RBC) [nr-271106-contam.fasta] Isoform 2 of Voltage-dependent L-type calcium channel subunit alpha-1C OS=Rattus norvegicus GN=Cacna1c [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	2169 amino acids
Gene Ontology:
Cellular Component:	presynaptic membrane [IDA] postsynaptic density [UNKNOWN][IDA] caveolar macromolecular signaling complex [UNKNOWN][IEA] voltage-gated calcium channel complex [UNKNOWN][IDA][IEA][TAS] neuronal cell body [UNKNOWN][IDA] plasma membrane [UNKNOWN] membrane fraction [UNKNOWN][IDA] nucleus [IDA] Z disc [IDA] T-tubule [IDA] dendrite [IDA] cytoplasm [UNKNOWN][IEA] sarcolemma [IDA] dendritic shaft [UNKNOWN][IEA] membrane [IEA] integral to membrane [UNKNOWN][IEA]
Biological Process:	transmembrane transport [IEA] insulin secretion [UNKNOWN][IEA] synaptic transmission [UNKNOWN][IEA] visual learning [UNKNOWN][IEA] regulation of organ growth [UNKNOWN][IEA] regulation of blood pressure [UNKNOWN][IEA] cellular calcium ion homeostasis [UNKNOWN][IEA] elevation of cytosolic calcium ion concentration [UNKNOWN] adult walking behavior [UNKNOWN][IEA] ion transport [IEA] smooth muscle contraction [UNKNOWN][IEA] calcium ion transport [UNKNOWN][IEA][IMP] glucose homeostasis [UNKNOWN][IEA] growth hormone secretion [UNKNOWN][IEA] calcium ion-dependent exocytosis [UNKNOWN][IEA] smooth muscle contraction involved in micturition [UNKNOWN][IEA] regulation of vasoconstriction [UNKNOWN][IEA]
Molecular Function:	ion channel activity [IEA] calmodulin binding [UNKNOWN][IEA] protein domain specific binding [IPI] protein binding [UNKNOWN][IPI] voltage-gated ion channel activity [IEA] dihydropyridine-sensitive calcium channel activity [UNKNOWN][IEA] voltage-gated calcium channel activity [UNKNOWN][IDA][IEA][IMP][TAS] protein phosphatase 2A binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRAFAQPST PPYQPLSSCL SEDTERKFKG KVVHEAQLNC FYISPGGSNY GSPRPAHANM  60
   61 NANAAAGLAP EHIPTPGAAL SWLAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK 120
  121 KQGGTTATRP PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 180
  181 DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF IIVVVGLFSA 240
  241 ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH 300
  301 IALLVLFVII IYAIIGLELF MGKMHKTCYN QEGIIDVPAE EDPSPCALET GHGRQCQNGT 360
  361 VCKPGWDGPK HGITNFDNFA FAMLTVFQCI TMEGWTDVLY WMQDAMGYEL PWVYFVSLVI 420
  421 FGSFFVLNLV LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 480
  481 NEDEGMDEDK PRNMSMPTSE TESVNTENVA GGDIEGENCG ARLAHRISKS KFSRYWRRWN 540
  541 RFCRRKCRAA VKSNVFYWLV IFLVFLNTLT IASEHYNQPH WLTEVQDTAN KALLALFTAE 600
  601 MLLKMYSLGL QAYFVSLFNR FDCFIVCGGI LETILVETKI MSPLGISCWR CVRLLRIFKI 660
  661 TRYWNSLSNL VASLLNSLRS IASLLLLLFL FIIIFSLLGM QLFGGKFNFD EMQTRRSTFD 720
  721 NFPQSLLTVF QILTGEDWNS VMYDGIMAYG GPSFPGMLVC IYFIILFISP NYILLNLFLA 780
  781 IAVDNLADAE SLTSAQKEEE EEKERKKLAR TASPEKKQEV MEKPAVEESK EEKIELKSIT 840
  841 ADGESPPTTK INMDDLQPSE NEDKSPHSNP DTAGEEDEEE PEMPVGPRPR PLSELHLKEK 900
  901 AVPMPEASAF FIFSPNNRFR LQCHRIVNDT IFTNLILFFI LLSSISLAAE DPVQHTSFRN 960
  961 HILFYFDIVF TTIFTIEIAL KMTAYGAFLH KGSFCRNYFN ILDLLVVSVS LISFGIQSSA1020
 1021 INVVKILRVL RVLRPLRINR AKGLKHVVQC VFVAIRTIGN IVIVTTLLQF MFACIGVQLF1080
 1081 KGKLYTCSDS SKQTEAESKG NYITYKTGEV DHPIIQPRSW ENSKFDFDNV LAAMMALFTV1140
 1141 STFEGWPELL YRSIDSHTED KGPIYNYRVE ISIFFIIYII IIAFFMMNIF VGFVIVTFQE1200
 1201 QGEQEYKNCE LDKNQRQCVE YALKARPLPR YIPKNQHQYK VWYVVNSTYF EYLMFVLILL1260
 1261 NTICLAMQHY GQSCLFKIAM NILNMLFTGL FTVEMILKLI AFKPKHYFCD AWNTFDALIV1320
 1321 VGSIVDIAIT EVHPAEHTQC SPSMSAEENS RISITFFRLF RVMRLVKLLS RGEGIRTLLW1380
 1381 TFIKSFQALP YVALLIVMLF FIYAVIGMQV FGKIALNDTT EINRNNNFQT FPQAVLLLFR1440
 1441 CATGEAWQDI MLACMPGKKC APESEPSNST EGETPCGSSF AVFYFISFYM LCAFLIINLF1500
 1501 VAVIMDNFDY LTRDWSILGP HHLDEFKRIW AEYDPEAKGR IKHLDVVTLL RRIQPPLGFG1560
 1561 KLCPHRVACK RLVSMNMPLN SDGTVMFNAT LFALVRTALR IKTEGNLEQA NEELRAIIKK1620
 1621 IWKRTSMKLL DQVVPPAGDD EVTVGKFYAT FLIQEYFRKF KKRKEQGLVG KPSQRNALSL1680
 1681 QAGLRTLHDI GPEIRRAISG DLTAEEELDK AMKEAVSAAS EDDIFRRAGG LFGNHVSYYQ1740
 1741 SDSRSNFPQT FATQRPLHIN KTGNNQADTE SPSHEKLVDS TFTPSSYSST GSNANINNAN1800
 1801 NTALGRFPHP AGYSSTVSTV EGHGPPLSPA VRVQEAAWKL SSKRCHSRES QGATVSQDMF1860
 1861 PDETRSSVRL SEEVEYCSEP SLLSTDILSY QDDENRQLTC LEEDKREIQP CPKRSFLRSA1920
 1921 SLGRRASFHL ECLKRQKDQG GDISQKTALP LHLVHHQALA VAGLSPLLQR SHSPSTFPRP1980
 1981 RPTPPVTPGS RGRPLQPIPT LRLEGAESSE KLNSSFPSIH CSSWSEETTA CSGGSSMARR2040
 2041 ARPVSLTVPS QAGAPGRQFH GSASSLVEAV LISEGLGQFA QDPKFIEVTT QELADACDMT2100
 2101 IEEMENAADN ILSGGAQQSP NGTLLPFVNC RDPGQDRAVV PEDESCVYAL GRGRSEEALP2160
 2161 DSRSYVSNL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: CAC1C_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: