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Protein Overview: CCL5_RAT

General Information:
Name(s) found: CCL5_RAT [Swiss-Prot]
Description(s) found:
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  • gi|459152|gb|AAA96499.1| RANTES [NCBI NR]
  • gi|1711393|sp|P50231.1|CCL5_RAT RecName: Full=C-C motif chemokine 5; AltName: Full=Small-inducible cytokine A5; AltName: Full=T-cell-specific protein RANTES; AltName: Full=SIS-delta; Flags: Precursor [NCBI NR]
  • ref|NP_112378.1| chemokine (C-C motif) ligand 5 [Rattus norvegicus] [NCBI NR]
  • (P50231) Small inducible cytokine A5 precursor (CCL5) (T-cell specific RANTES protein) (SIS-delta) [Swiss-Prot]
  • C-C motif chemokine 5 OS=Rattus norvegicus GN=Ccl5 PE=3 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-69773021 Small inducible cytokine A5 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • chemokine (C-C motif) ligand 5; small inducible cytokine A5 (RANTES); small inducible cytokine A5 [HMR_022704-rand.fasta]
  • chemokine (C-C motif) ligand 5 [Rattus norvegicus]gi|1711393|sp|P50231|SY05_RAT Small inducible cytokine A5 precursor (CCL5) (T-cell specific RANTES protein) (SIS-delta)gi|459152|gb|AAA96499.1| RANTES [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Small inducible cytokine A5 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031116) small inducible cytokine A5; small inducible cytokine A5 (RANTES) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • C-C motif chemokine 5 precursor (Small-inducible cytokine A5) (T-cell-specific protein RANTES) (SIS-delta) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • RANTES [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SMALL INDUCIBLE CYTOKINE A5 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Small inducible cytokine A5 precursor (CCL5) (T-cell-specific RANTES protein) (SIS-delta) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Ccl5 C-C motif chemokine 5 [rat-ipi-250309-contam.fasta]
  • C-C motif chemokine 5 OS=Rattus norvegicus GN=Ccl5 [011711_HMR.fasta]
  • C-C motif chemokine 5 OS=Rattus norvegicus GN=Ccl5 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 92 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [IDA]
    soluble fraction [IDA]
    cytoplasm [UNKNOWN][IEA]
    extracellular region [UNKNOWN][IEA]
    Biological Process: response to cytokine stimulus [UNKNOWN][IEP]
    aging [IEP]
    chronic inflammatory response [IEP]
    chemotaxis [IEA]
    inflammatory response [IEP]
    immune response [IEA]
    response to insulin stimulus [IEP]
    positive regulation of osteoclast differentiation [IDA]
    lymphocyte chemotaxis [IDA]
    response to drug [IEP]
    response to glucocorticoid stimulus [IEP]
    response to lipopolysaccharide [IEP]
    positive regulation of fever [IDA]
    negative regulation of viral genome replication [UNKNOWN][IEA]
    response to tumor necrosis factor [UNKNOWN][IEA]
    Molecular Function: chemoattractant activity [UNKNOWN][IEA]
    chemokine activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKISAAASLT VILVAAALCT PVPASPYGSD TTPCCFAYLS LALPRAHVKE YFYTSSKCSN  60
   61 LAVVFVTRRN RQVCANPEKK WVQEYINYLE MS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..92] PSI-BLAST 19.09691 RANTES (regulated upon activation, normal T-cell expressed and secreted)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine activity
    		•  8.07273475133641 bayes_pls_golite062009
  • chemokine receptor binding
    		•  7.19574940007631 bayes_pls_golite062009
  • chemokine activity
    		•  7.19574940007631 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  7.12866319987718 bayes_pls_golite062009
  • receptor binding
    		•  5.70505228637425 bayes_pls_golite062009
  • protein binding
    		•  3.96178206863622 bayes_pls_golite062009
  • interleukin-8 receptor binding
    		•  3.86135397575984 bayes_pls_golite062009
  • binding
    		•  3.44333267537536 bayes_pls_golite062009
  • chemoattractant activity
    		•  3.05299139114464 bayes_pls_golite062009
  • heparin binding
    		•  2.48790323783525 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.80091312295242 bayes_pls_golite062009
  • CCR2 chemokine receptor binding
    		•  1.78317158345185 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.28416986663426 bayes_pls_golite062009
  • pattern binding
    		•  1.02739535268516 bayes_pls_golite062009
  • CCR chemokine receptor binding
    		•  0.697359799598971 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.14673741350408 bayes_pls_golite062009
  • transporter activity
    		•  0.0541029584618528 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle