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A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual. The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. Any process that modulates the frequency, rate, or extent of a chronic inflammatory response. Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response. Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response. A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response. The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: chronic inflammatory response
Acc: GO:0002544
Aspect: Biological Process
Desc: Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.
Proteins in PDR annotated with:
   This term: 11 [Search]
   Term or descendants: 39 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0002544 - chronic inflammatory response (interactive image map)
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