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Protein Overview: TOP2A_RAT

General Information:
Name(s) found: TOP2A_RAT [Swiss-Prot]
Description(s) found:
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  • gi|587515|emb|CAA86496.1| DNA topoisomerase II [Rattus norvegicus] [NCBI NR]
  • gi|1174742|sp|P41516.1|TOP2A_RAT RecName: Full=DNA topoisomerase 2-alpha; AltName: Full=DNA topoisomerase II, alpha isozyme [NCBI NR]
  • (P41516) DNA topoisomerase II, alpha isozyme (EC 5.99.1.3) [Swiss-Prot]
  • DNA topoisomerase 2-alpha OS=Rattus norvegicus GN=Top2a PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-86103070 DNA topoisomerase II, alpha isozyme [hmr_yeast5_DM3-1_pombe.fasta]
  • DNA topoisomerase II [Rattus norvegicus]gi|1174742|sp|P41516|TP2A_RAT DNA topoisomerase II, alpha isozyme [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 DNA topoisomerase 2-alpha [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_022183) topoisomerase (DNA) 2 alpha; topoisomerase (DNA) II alpha [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Tax_Id=10116 DNA topoisomerase II, alpha isozyme [EBI-IPI_rat_3.08_07-12-2005_origrev_con.fasta]
  • DNA topoisomerase 2-alpha (DNA topoisomerase II, alpha isozyme) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • DNA topoisomerase II [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 DNA TOPOISOMERASE II, ALPHA ISOZYME [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Top2a DNA topoisomerase 2-alpha [rat-ipi-250309-contam.fasta]
  • DNA topoisomerase 2-alpha OS=Rattus norvegicus GN=Top2a [011711_HMR.fasta]
  • DNA topoisomerase 2-alpha OS=Rattus norvegicus GN=Top2a PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
    • Organism: Rattus norvegicus
    Length: 1526 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [UNKNOWN]
    nucleus [UNKNOWN][IDA][IEA]
    cytoplasm [UNKNOWN]
    centriole [UNKNOWN]
    DNA topoisomerase complex (ATP-hydrolyzing) [UNKNOWN][IDA]
    nuclear chromosome [UNKNOWN]
    chromosome [IEA]
    protein complex [UNKNOWN]
    [NOT]nucleolus [UNKNOWN][IDA]
    nucleoplasm [UNKNOWN]
    Biological Process: embryonic cleavage [UNKNOWN]
    cerebellar granule cell differentiation [IEP]
    cerebellar Purkinje cell differentiation [IEP]
    chromosome condensation [UNKNOWN]
    DNA ligation [UNKNOWN]
    chromosome segregation [UNKNOWN]
    DNA topological change [UNKNOWN][IDA][IEA]
    brain development [IEP]
    response to DNA damage stimulus [UNKNOWN]
    aging [IEP]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    positive regulation of retroviral genome replication [UNKNOWN]
    response to drug [IEP]
    positive regulation of apoptosis [UNKNOWN]
    apoptotic chromosome condensation [UNKNOWN]
    positive regulation of viral genome replication [UNKNOWN]
    response to parathyroid hormone stimulus [IEP]
    Molecular Function: protein kinase C binding [UNKNOWN]
    DNA-dependent ATPase activity [UNKNOWN]
    protein homodimerization activity [UNKNOWN]
    drug binding [UNKNOWN]
    histone deacetylase binding [UNKNOWN]
    protein C-terminus binding [UNKNOWN]
    sequence-specific DNA binding [IDA]
    chromatin binding [UNKNOWN][IDA]
    structure-specific DNA binding [IDA]
    DNA binding [UNKNOWN][IEA][TAS]
    ATP binding [IDA][IEA][TAS]
    protein binding [UNKNOWN]
    ubiquitin binding [UNKNOWN]
    protein heterodimerization activity [UNKNOWN]
    DNA topoisomerase activity [IDA]
    DNA topoisomerase (ATP-hydrolyzing) activity [UNKNOWN][IDA][IEA]
    enzyme binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELSPLQPVN ENMLLNKKKN EDGKKRLSVE RIYQKKTQLE HILLRPDTYI GSVELVTQQM  60
   61 WVYDEDVGIN YREVTFVPGL YKIFDEILVN AADNKQRDPK MSCIRVTMMR NNLISIWNNG 120
  121 KGIPVVEHKV EKMYVPALIF GQLLTSSNYD DDEKKVTGGR NGYGAKLCNI FSTKFTVETA 180
  181 SREYKKMFKQ TWMDNMGRAG DMELKPFSGE DYTCITFQPD LSKFKMQSLD KDIVALMVRR 240
  241 AYDIAGSTKD VKVFLNGNRL PVKGFRSYVD MYLKDKVDET GNALKVVHEQ VNPRWEVCLT 300
  301 MSEKGFQQIS FVNSIATSKG GRHVDYVADQ IVSKLVDVVK KKNKGGVAVK ADQVKNHMWI 360
  361 FGNAVIENPT FDSQTKENMT LQAKSFGSTC QLSEKFIKAA IGCGIVESIL NWVKFKAQIQ 420
  421 LNKKCSAVKH NRIKGIPKLD DANDAGSRNS AECTLILTEG DSAKTLAVSG LGVVGRDKYG 480
  481 VFPLRGKILN VREASHKQIM ENAEINNIIK IVGLQYKKNY EDEDSLKTLR YGKIMIMTDQ 540
  541 DQDGSHIKGL LINFIHHNWP SLLRHRFLEE FITPIVKVSK NKQEIAFYSL PEFEEWKSTN 600
  601 PNHKKWKVKY YKGLGTSTSK EAKEYFANMK RHRIQFKYSG PEDDAAISLA FSKKQVDDRK 660
  661 EWLTNFMEDR RQRKLLGLPE DYLYGQTTMY LTYNDFINKE LILFSNSDNE RSIPSMVDGL 720
  721 KPGQRKVLFT CFKRNDKREV KVAQLAGSVA EMSSYHHGEM SLMMTIINLA QNFVGSNNLN 780
  781 LLQPIGQFGT RLHGGKDSAS PRYIFTMLSP LARLLFPSKD DHTLRFLYDD NQRVEPEWYI 840
  841 PIIPMVLING AEGIGTGWSC KIPNFDVREV VNNIRRLLDG EEPLPMLPSY KNYKGTIEEL 900
  901 ASNQYVINGE VAILNSTTIE ITELPIRTWT QTYKEQVLEP MLNGTEKTPP LITDYREYHT 960
  961 DTTVKFVIKM TEEKLAEAER VGLHKVFKLQ TSLTCNSMVL FDHVGCLKKY DTVLDILRDF1020
 1021 FELRLKYYGL RKEWLLGMLG AESSKLNNQA RFILEKIDGK IVIENKPKKE LIKVLIQRGY1080
 1081 DSDPVKAWKE AQQKVPEEEE NEENEESESE STSPAAESGP TFNYLLDMPL WYLTKEKKDE1140
 1141 LCKQRDEKEQ ELNTLKKKTP SDLWKEDLAA FVEELEVVEA KEKQDEQVGL PGKGVKAKGK1200
 1201 KAQISEVLPS PVGKRVIPQV TMEMRAEAEK KIRRKIKSEN VEGTPAEDGA EPGLRQRLEK1260
 1261 RQKREPGTRA KKQTTLPFKP IKKAQKQNPW SDSESDMSSN ESNFDVPPRE KEPRIAATKA1320
 1321 KFTADLDSDD DFSGLDEKDE DEDFFPLDDT PPKTKMPPKN TKKALKPQKS STSVDLESDG1380
 1381 KDSVPASPGA SAADVPAETE PSKPSSKQTV GVKRTITKGQ SLTSTAGTKK RAVPKETKSD1440
 1441 SALNAHVSKK PAPAKAKNSR KRMPSSSDSS DSEFEKAISK GATSKKLKGE ERDFHVDLDD1500
 1501 TVAPRAKSGR ARKPIKYLEE SDDDLF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle