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Protein Overview: MP2K5_RAT

General Information:
Name(s) found: MP2K5_RAT [Swiss-Prot]
Description(s) found:
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  • gi|77157802|ref|NP_001029159.1| mitogen-activated protein kinase kinase 5 isoform a [Rattus norvegicus] [NCBI NR]
  • gi|51260683|gb|AAH78860.1| Mitogen activated protein kinase kinase 5 [Rattus norvegicus] [NCBI NR]
  • gi|2499634|sp|Q62862.1|MP2K5_RAT RecName: Full=Dual specificity mitogen-activated protein kinase kinase 5; Short=MAP kinase kinase 5; Short=MAPKK 5; AltName: Full=MAPK/ERK kinase 5 [NCBI NR]
  • gi|1586288|prf||2203378A MAP/ERK kinase MEK5 [NCBI NR]
  • gi|149041926|gb|EDL95767.1| mitogen activated protein kinase kinase 5, isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • gi|1016332|gb|AAC52320.1| MEK5alpha-1 [NCBI NR]
  • (Q62862) Dual specificity mitogen-activated protein kinase kinase 5 (EC 2.7.1.-) (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) [Swiss-Prot]
  • Dual specificity mitogen-activated protein kinase kinase 5 OS=Rattus norvegicus GN=Map2k5 PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):None Splice isoform Alpha-1 of Q62862 [hmr_yeast5_DM3-1_pombe.fasta]
  • Map2k5 protein [Rattus norvegicus]gi|2499634|sp|Q62862|MPK5_RAT Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5)gi|1016332|gb|AAC52320.1| MEK5alpha-1gi|1586288|prf||2203378A MAP/ERK kinase M [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform Alpha-1 of Dual specificity mitogen-activated protein kinase kinase 5 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (MAPK/ERK kinase 5) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mitogen activated protein kinase kinase 5 isoform a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mitogen activated protein kinase kinase 5, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Mitogen activated protein kinase kinase 5 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MEK5alpha-1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MAP/ERK kinase MEK5 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • mitogen-activated protein kinase kinase 5 isoform a [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Map2k5 Isoform Alpha-1 of Dual specificity mitogen-activated protein kinase kinase 5 [rat-ipi-250309-contam.fasta]
  • Isoform Alpha-1 of Dual specificity mitogen-activated protein kinase kinase 5 OS=Rattus norvegicus GN=Map2k5 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 448 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IEA]
    membrane [IEA]
    spindle [UNKNOWN][IEA]
    cytosol [UNKNOWN][IDA]
    Biological Process: MAPKKK cascade [UNKNOWN][IC]
    heart development [UNKNOWN][IEA]
    positive regulation of cell growth [IMP]
    BMK cascade [IMP]
    protein amino acid phosphorylation [IDA][IEA]
    positive regulation of epithelial cell proliferation [IDA]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IDA][IEA]
    protein tyrosine kinase activity [IEA]
    protein binding [UNKNOWN][IEA]
    metal ion binding [IEA]
    MAP kinase kinase activity [IC]
    MAP kinase activity [UNKNOWN]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWLALGPFR AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF  60
   61 EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 120
  121 KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 180
  181 YKAYHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 240
  241 TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTSGQVKLC 300
  301 DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 360
  361 KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 420
  421 QFNDGNATVV SMWVCRALEE RRSQQGPP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle