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A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways. Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the BMK cascade. Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the BMK cascade. A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase. Any process that modulates the frequency, rate or extent of signal transduction mediated by the BMK cascade. A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: BMK cascade
Acc: GO:0070375
Aspect: Biological Process
Desc: A cascade of protein kinase activities, culminating in the phosphorylation and activation of big MAP kinase (BMK1/ERK5), which is a type of mitogen-activated protein (MAP) kinase.
Synonyms:
  • ERK5 cascade
  • BMK signalling pathway
  • MAPK7 cascade
  • ERK5 signaling pathway
  • BMK signaling pathway
  • BMK1 cascade
Proteins in PDR annotated with:
   This term: 4 [Search]
   Term or descendants: 4 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070375 - BMK cascade (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle