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Protein Overview: ZNF254

General Information:
Name(s) found: ZNF254 [HGNC (HUGO)]
Description(s) found:
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  • gi|215274193|sp|O75437.3|ZN254_HUMAN RecName: Full=Zinc finger protein 254; AltName: Full=Bone marrow zinc finger 5; Short=BMZF-5; AltName: Full=Hematopoietic cell-derived zinc finger protein 1; Short=HD-ZNF1; AltName: Full=Zinc finger protein 539; AltNam [NCBI NR]
  • gi|141794888|gb|AAI39750.1| Zinc finger protein 254 [Homo sapiens] [NCBI NR]
  • gi|119605366|gb|EAW84960.1| hCG19985, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|116256449|ref|NP_975011.3| zinc finger protein 254 [Homo sapiens] [NCBI NR]
  • zinc finger protein 254 [HGNC (HUGO)]
  • Zinc finger protein 254 OS=Homo sapiens GN=ZNF254 PE=2 SV=3 [Swiss-Prot]
  • zinc finger protein 254 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Zinc finger protein 539 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • zinc finger protein 254 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Zinc finger protein 254 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • hCG19985, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 ZINC FINGER PROTEIN 539 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=ZNF254 Isoform 1 of Zinc finger protein 254 [human-ipi-250309-contam.fasta]
  • IPI:IPI00411674.7|SWISS-PROT:O75437-1|TREMBL:A8K5H1;B4E0L9|ENSEMBL:ENSP00000349494|REFSEQ:NP_975011|VEGA:OTTHUMP00000078311 Tax_Id=9606 Gene_Symbol=ZNF254 Isoform 1 of Zinc finger protein 254 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=ZNF254 zinc finger protein 254 ENSG00000183850 IPI00845468 IPI00384898 IPI00411674 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=ZNF254 zinc finger protein 254 isoform 1 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • Zinc finger protein 254 OS=Homo sapiens GN=ZNF254 PE=1 SV=3 [UniProtHuman070710.fasta]
  • O75437;A4QPC0;Q86XL7; RecName: Full=Zinc finger protein 254; AltName: Full=Bone marrow zinc finger 5; AltName: Full=Hematopoietic cell-derived zinc finger protein 1; AltName: Full=Zinc finger protein 539; AltName: Full=Zinc finger protein 91-like; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Zinc finger protein 254 OS=Homo sapiens GN=ZNF254 [011711_HMR.fasta]
  • GeneSymbol=ZNF254 Synonyms=BMZF-5|FLJ58216|HD-ZNF1|ZNF539|ZNF91L zinc finger protein 254 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00411674.7|SWISS-PROT:O75437-1|TREMBL:A8K5H1;B4E0L9|ENSEMBL:ENSP00000349494|REFSEQ:NP_975011 Tax_Id=9606 Gene_Symbol=ZNF254 Isoform 1 of Zinc finger protein 254 [ipi.HUMAN.20110912.fasta]
  • Zinc finger protein 254 GN=ZNF254 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 659 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGPPRSLEM GLLTFRDVAI EFSLEEWQHL DIAQQNLYRN VMLENYRNLA FLGIAVSKPD  60
   61 LITCLEQGKE PWNMKRHEMV DEPPGMCPHF AQDLWPEQGM EDSFQKAILR RYGKYGHENL 120
  121 QLRKGCKSVD EYKVNKEGYN GLNQCFTTAQ SKVFQCDKYL KVFYKFLNSN RPKIRHTEKK 180
  181 SFKCKKRVKL FCMLSHKTQH KSIYHREKSY KCKECGKTFN WSSTLTNHRK IYTEEKPYKC 240
  241 EEYNKSPKQL STLTTHEIIH AGEKLYKCEE CGEAFNRSSN LTTHKIIHTG EKPYKCEECG 300
  301 KAFIWSSTLT EHKKIHTRKK PYKCEECGKA FIWSSTLTRH KRMHTGEKPY KCEECGKAFS 360
  361 QSSTLTTHKI IHTGEKRYKC LECGKAFKQL STLTTHKIIH VGEKLYKCEE CGKGFNRSSN 420
  421 LTTHKIIHTG EKPYKCEECG KAFIWSSTLT KHKRIHTREK PYKCEECGKA FIWSSTLTRH 480
  481 KRMHTGEKPY KCEECGKSFS QSSTLTTHKI IHTGEKPYKC EECGKAFNWS STLTKHKIIH 540
  541 TEEKPYKCEK CGKAFKQSSI LTNHKRIHTG EKPYKCEECG KSFNRSSTFT KHKVIHTGVK 600
  601 PYKCEECGKA FFWSSTLTKH KRIHTGEQPY KWEKFGKAFN RSSHLTTDKI THWREILQV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..64] FFAS03 2.87 Solution structure of the Kruppel-associated box (KRAB) domain
    2 View Details [65..252] FFAS03 8.08 No description for 2i13A was found.
    3 View Details [253..417] PSI-BLAST 44.69897 No description for 2i13A was found.
    4 View Details [418..589] PSI-BLAST 13.69897 Transcription factor IIIA, TFIIIA
    5 View Details [590..659] PSI-BLAST 10.69897 Five-finger GLI1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.35084112049258 bayes_pls_golite062009
  • DNA binding
    		•  2.22582111349682 bayes_pls_golite062009
  • binding
    		•  2.0499154380126 bayes_pls_golite062009
  • protein binding
    		•  1.52777775948113 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription activator activity
    		•  3.52873291636993 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.53101891154822 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • protein binding
    		•  2.05530362750351 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.48624530884061 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.31662328614288 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.18599503594288 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.912796194488319 bayes_pls_golite062009
  • tubulin binding
    		•  0.885027017225994 bayes_pls_golite062009
  • microtubule binding
    		•  0.780072635419707 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  4.70988788192472 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.58713908116892 bayes_pls_golite062009
  • DNA binding
    		•  4.56219307357342 bayes_pls_golite062009
  • transcription activator activity
    		•  3.52873291636993 bayes_pls_golite062009
  • transcription factor activity
    		•  3.50954949535763 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.27542149084008 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22082323675675 bayes_pls_golite062009
  • binding
    		•  3.10743787485868 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.53101891154822 bayes_pls_golite062009
  • chromatin binding
    		•  2.18464662431232 bayes_pls_golite062009
  • protein binding
    		•  2.05530362750351 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.63161912031789 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.48624530884061 bayes_pls_golite062009
  • transcription factor binding
    		•  1.39608963544799 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.34049786451995 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.31662328614288 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.18599503594288 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.912796194488319 bayes_pls_golite062009
  • tubulin binding
    		•  0.885027017225994 bayes_pls_golite062009
  • microtubule binding
    		•  0.780072635419707 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.77874411480713 bayes_pls_golite062009
  • catalytic activity
    		•  0.245893663605433 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle