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View Structure Prediction Details

Protein: ZNF254
Organism: Homo sapiens
Length: 659 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZNF254.

Description E-value Query
Range		 Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
 0.0 [3..656] [2173..2882]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
 0.0 [12..656] [604..1255]

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Predicted Domain #1
Region A:
Residues: [1-64] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGPPRSLEM GLLTFRDVAI EFSLEEWQHL DIAQQNLYRN VMLENYRNLA FLGIAVSKPD  60
   61 LITC

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.87
Match: 1v65A
Description: Solution structure of the Kruppel-associated box (KRAB) domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.35084112049258 bayes_pls_golite062009
DNA binding 2.22582111349682 bayes_pls_golite062009
binding 2.0499154380126 bayes_pls_golite062009
protein binding 1.52777775948113 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEQGKEPWNM KRHEMVDEPP GMCPHFAQDL WPEQGMEDSF QKAILRRYGK YGHENLQLRK  60
   61 GCKSVDEYKV NKEGYNGLNQ CFTTAQSKVF QCDKYLKVFY KFLNSNRPKI RHTEKKSFKC 120
  121 KKRVKLFCML SHKTQHKSIY HREKSYKCKE CGKTFNWSST LTNHRKIYTE EKPYKCEEYN 180
  181 KSPKQLST

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 8.08
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [253-417] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTTHEIIHAG EKLYKCEECG EAFNRSSNLT THKIIHTGEK PYKCEECGKA FIWSSTLTEH  60
   61 KKIHTRKKPY KCEECGKAFI WSSTLTRHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH 120
  121 TGEKRYKCLE CGKAFKQLST LTTHKIIHVG EKLYKCEECG KGFNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #4
Region A:
Residues: [418-589] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSNLTTHKII HTGEKPYKCE ECGKAFIWSS TLTKHKRIHT REKPYKCEEC GKAFIWSSTL  60
   61 TRHKRMHTGE KPYKCEECGK SFSQSSTLTT HKIIHTGEKP YKCEECGKAF NWSSTLTKHK 120
  121 IIHTEEKPYK CEKCGKAFKQ SSILTNHKRI HTGEKPYKCE ECGKSFNRSS TF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
cytoskeletal protein binding 1.31662328614288 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
transcription coactivator activity 0.912796194488319 bayes_pls_golite062009
tubulin binding 0.885027017225994 bayes_pls_golite062009
microtubule binding 0.780072635419707 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [590-659] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKHKVIHTGV KPYKCEECGK AFFWSSTLTK HKRIHTGEQP YKWEKFGKAF NRSSHLTTDK  60
   61 ITHWREILQV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription activator activity 3.52873291636993 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
sequence-specific DNA binding 2.53101891154822 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
protein binding 2.05530362750351 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
structure-specific DNA binding 1.48624530884061 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
cytoskeletal protein binding 1.31662328614288 bayes_pls_golite062009
double-stranded DNA binding 1.18599503594288 bayes_pls_golite062009
transcription coactivator activity 0.912796194488319 bayes_pls_golite062009
tubulin binding 0.885027017225994 bayes_pls_golite062009
microtubule binding 0.780072635419707 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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